Objective: To explore the suitable load of endurance training for primary school students with different BMI levels living in 3 200 m plateau, and to provide guidance for exercise and weight control for children residing in high altitudes. Methods: The heart rate deflection point (HRDP) and HRDPspeed of 7-12 year-old students residing at high altitude were evaluated by using the site Conconi test. The serum lipid metabolism level was detected by ELISA. The correlation between HRDP and lipid metabolism was analyzed by Pearson correlation analysis. Results: The level of leptin, adiponectin, total cholesterol(TC) and triglycerides(TG) in obesity group was highest, follow by the overweight group, normal weight and under-weight group(F=3.75-24.12, P<0.05). In the same age group, hrdpspeed decreased with the increase of BMI. For children with the same BMI classification, HRDPspeed decreased with age. HRDPspeed showed an increasing trend by age and BMI. In obese, normal and emaciated students, there was a significant negative correlation between lipid metabolism and HRDP, but there was no significant correlation between lipid metabolism and HRDP in overweight students of different ages (P>0.05). Conclusion It is suggested that HRDP and lipid metabolism may be signcficantly correlated with BMI in students aged 7-12 years at different BMI levels in plateav and the above indicators can be used as an effective means to evaluate aerobic exercise endurance capacity of healthy adults at plateau.

Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule with important roles in the regulation of apoptosis, differentiation and invasion of cancer cells, but the detailed is largely still unknown. We analyzed the mRNA levels and methylation statuses of EMP3 in 63 primary breast carcinomas and assessed their correlations with clinicopathologic variables. The expression of EMP3 mRNA in primary breast carcinomas was significantly higher than the expression of 20 normal breast tissues (p<10(-7)). EMP3 overexpression in breast carcinomas was significantly related to histological grade III (p=3.9X10(-7)), lymph node metastasis (p= 0.003), and strong Her-2 expression (p=3.3X10(-6)). Hypermethylation frequencies of EMP3 were detected in 36.5% of breast carcinomas by methylation-specific polymerase chain reaction. However, no significant correlations were found between methylation status of EMP3 and mRNA expression levels as well as other clinical parameters. In conclusion, EMP3 may be a novel marker of tumor aggressiveness. Overexpression of EMP3 in primary breast carcinoma is not associated with DNA methylation.
Adult ; Breast Neoplasms/*genetics/pathology ; Carcinoma/*genetics/pathology ; DNA Methylation ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphatic Metastasis ; Membrane Glycoproteins/*genetics/metabolism ; Middle Aged ; Neoplasm Staging ; RNA, Messenger/metabolism ; Receptor, erbB-2/genetics/metabolism ; Severity of Illness Index

This study was aimed to investigate the effects of Fomes officinalis polysaccharides (FoP) on exercise-induced fatigue and exercise immune suppression in mice with FoP induced by exercise fatigue and unbalanced exercise immunity.Through treadmill exercise,the long-term exercise immune suppression model fatigue was established.Different doses of FoP were used in the animal experiment.The experimental animal were randomly divided into the positive control group,negative control group,low dose FoP (20 mg· kg-1) + exercise group,middle dose FoP (40 mg· kg-1) + exercise group,and the high dose FoP (80 mg· kg-1) + exercise group.The intragastric administration was given 6 days per week for 8 weeks.Treadmill exercise was administered during these 8 weeks.After 8 weeks,the samples were sacrificed.The levels of malondialdehyde (MDA),superoxide dismutase (SOD),hemoglobin (HB) and creatine kinase (CK) were detected by kit.And the relative expression of IL-4mRNA,INF-γmRNA was detected by RT-PCR.The results showed that compared with the positive control group,FoP can significantly improve the level of HB in mice,the level of serum CK in each FoP dose group was significantly decreased;compared with the positive control group,FoP group can significantly eliminate MDA with no significant difference among different FoP dose groups.The contents of SOD in serum of different dose FoP group and the negative control group were significantly higher than that of the positive control group.The IL-4 mRNA/INF-γ mRNA ratio of different dose FoP group were in basic equilibrium.It was concluded that Uygur FoP can effectively promote the body fatigue recovery,accelerate the clearance of free radicals,and improve the antioxidant ability and immune status.

This paper summarizes the current research on teaching performance appraisal management of teaching hospitals at home and abroad, analyzes existing problems in teaching performance appraisal at present, and puts forward that teaching performance appraisal should be included in hospital performance appraisal. The principle of "informatization and anonymity" should be adopted to evaluate the teaching quality of clinical teachers, so that clinical teachers can participate in teaching performance appraisal management, and the indicators and weights of teaching performance appraisal can be determined scientifically and reasonably.

Objective To evaluate and analyze the feasibility and application effect of ^“DOTS + WeChat^” in the treatment and management of tuberculosis patients. Methods From 2018 to 2019, a total of 2 420 active pulmonary tuberculosis patients were registered in Zibo City, and 1 988 patients meeting the inclusion criteria were selected as the research subjects. 836 patients were randomly enrolled under the ^“DOTS + WeChat^” integrated management mode, while the other 1152 cases were treated with single DOTS management mode. The regular medication status, treatment and outcome, and core knowledge awareness of the two groups were analyzed by SPSS16.0 software, χ²- test and t- test methods. Result The ^“DOTS + WeChat^” comprehensive management group had higher a regular medication rate (98.80%), coincidence rate of sputum test times (95.81%), and success rate of treatment (98.68%) than the single DOTS management group (92.10%, 90.19%, and 96.53%) (P=0.000, 0.000, 0.003). The rate of medical staff participating in supervision and management in the comprehensive management group (100%) was higher than that in the single management group (75.87%) (P=0.000). The complete follow-up rate in the consolidation period (100%) and the complete whole course follow-up rate (99.76%) were both higher than those in the single management group (P=0.000, 0.001). The awareness level of core knowledge in the comprehensive management group (78.58±4.32) was higher than that in the single management group (70.70±8.02) (P=0.000). Conclusion The application of WeChat management mode has a positive effect on the treatment and management of tuberculosis patients in Zibo City. It is a feasible and effective supplement and improvement to the current tuberculosis control and management measures, which is worthy of further promotion and exploration.