0.05).[Conclusion]1.It showes a higher stress dodge in the calcar femorale after using various kinds of prosthesis implantation.After using CFR/PSF of lower elastic modulus as handle,the stress dodge rate is lower in femur,but the interface stress is higher,and this is the main factor and reason for the prosthesis loosening.2.The stress force rule meets the design principle that the stress force decreases gradually in the bone interface from proximal to distal.The stress value in different combination of same prosthesis handle has no significant difference,that showes mechanical factor is not the main standard for selecting prosthesis combination.

[Objective] To study the clinical results of the total hip replacement with different materials prosthesis.[Methods]Eighty-five patients(nighty-two hips)undergoing total hip replacement were enrolled in this study.Through X-ray examination,the stress force of different material prosthesis on the proxmial femur and periaccetabular bone was observed.[Results]There were no clinical signs of the loose or bone absorption around the prostheses in all patients.Debris reaction was found in the metal-polyethylene group and ceramic-polyethylene group,not found in the metal-metal group and ceramic-ceramic group.[Conclusion]The stress force between different material prostheses and bone interface was not significantly different.Bone osteolysis doue to wear of polyethylene prosthesis is the key factor for the long-term outcomes of the total hip replacement.In addition,it is correlated with prosthesis manufacture,bone quanlity and surgical technique.

Osteomyelitis (OM) is still a major problem for orthopedists. Numerous studies have shown that genetic factors may play an important role in the pathogenesis of OM. As a third generation genetic marker, single nucleotide polymorphisms (SNPs) have received increasing attention from scholars who are studying genetic susceptibility to OM. In-depth research on the SNPs of susceptibility genes will help to explore new strategies for prevention, diagnosis and treatment of OM. This article reviews the research advances concerning gene SNPs and OM susceptibility.

Objective: To observe the clinical efficacy of sliding compression technique with proximal femoral nail antirotation (PFNA) for the treatment of intertrochanteric fractures in the elderly patients. Methods: A retrospective study was conducted in the 97 elderly patients with intertrochanteric fracture who had received PFNA internal fixation at Department of Orthopaedics, The Second Fuzhou Hospital Affiliated to Xiamen University from January 2010 to December 2017. They were divided into 2 groups depending on whether the sliding compression technique was used or not in the PFNA fixation. In the sliding compression group of 51 patients, there were 31 males and 20 females with an age of 79.9±6.2 years, and 2 cases of type Ⅰ, 8 cases of type Ⅱ, 21 cases of type Ⅲ, 16 cases of type Ⅳ, 3 cases of type Ⅴ and one case of type Ⅵ according to the modified Evans classification. In the conventional PENA group of 46 cases, there were 27 males and 19 females with an age of 77.5±8.0 years, and 3 cases of type Ⅰ, 6 cases of type Ⅱ, 15 cases of type Ⅲ, 18 cases of type Ⅳ and 4 cases of type Ⅴ according to the modified Evans classification. The 2 groups were compared in terms of the separation of fracture ends at immediate postoperation and 4 weeks postoperation, anesthesia time, operative time, intraoperative bleeding, fracture reduction, fracture healing time, Harris scores of hip function at one year postoperation and postoperative complications. Results: There were no significant differences between the 2 group of patients in their preoperative general data, indicating they were compatible (P>0.05). The sliding compression group had significantly shorter separation of fracture ends at immediate postoperation and at 4 weeks postoperation (2.18±0.59 mm and 0.92±0.27 mm) and significantly shorter fracture healing time (5.2±0.9 weeks) than the conventional PENA group (3.91±0.76 mm and 2.15±0.52 mm; 6.5±0.9 weeks) (P<0.05). There were no significant differences between the 2 groups in anesthesia time, operative time, intraoperative bleeding, fracture reduction or Harris scores of hip function at one year postoperation (P>0.05). The sliding compression group had significantly lower incidences in pulmonary infection [9.8% (5/51)], blade loosening or cutout [0 (0/51)] and incision complications [0 (0/51)] than the conventional PENA group [26.1% (12/46), 17.4% (8/46) and 19.6% (9/46), respectively] (P<0.05). Conclusions In the treatment of intertrochanteric fractures in the elderly people, sliding compression technique with PFNA may lead to fewer postoperative complications and faster fracture healing.

Objective To analyze the clinical efficacy of potassium permanganate soak combined with a closed negative pressure drainage device for treatment of bone and soft tissue infection.Methods A retrospective analysis was performed of the 83 patients with bone and soft tissue infection who had been treated at Department of Orthopaedics,The Second People's Hospital of Fuzhou from July 2010 to March 2017.They were 71 males and 12 females,aged from 15 to 77 years (median,44 years).Of them,47 were subjected to soakwith 1:5,000 potassium permanganate solution and 36 to soak with 1:5,000 gentamycin solution before a negative pressure sealing drainage device was applied for them all.The 2 groups were compared in terms of complications (pain,drainage device blockage or leakage,wound bleeding,tube pressure ulcer,and new nosocomial infection),time for negative bacterial culture,time for drainage device removal,time for wound closure,healing rate and recurrence rate.Results There were no significant differences between the 2 groups in pain,drainage device blockage or leakage,wound bleeding,or tube pressure ulcer (P ＞ 0.05).The rate of new nosocomial infection was significantly lower in the potassium permanganate group (2.1％)than in the gentamicin group (13.9％).The time for negative bacterial culture,drainage device removal and wound closure in the potassium permanganate group (6 d,12 d and 18.5 ± 1.9 d,respectively) was all significantly shorter than in the gentamicin group (9 d,15 d and 20.0 ±2.2 d,respectively) (P ＜ 0.05).The healing rate for the potassium permanganate group (100％) was significantly higher than that for the gentamicin group (86.1％);the recurrence rate (0) for the former was significantly lower than that for the latter (13.9％) (P ＜ 0.05).Conclusion Potassium permanganate soak combined with a negative pressure drainage device is effective,economical,convenient and safe for the treatment of bone and sofi tissue infection,compared with gentamicin soak combined with the same device.

Objective To compare the clinical efficacy of PFNA internal fixation for the treatment of femoral intertrochanteric fracture in the lateral position without traction table and supine position with traction table.To explore the surgical techniques of fixation using PFNA in lateral supine without traction table.Methods A retrospective study was conducted on 173 patients with intertrochanteric fracture fixed with PFNA in Fuzhou Second Hospital from January 2010 to January 2017.In the lateral position group,106 were operated in lateral position without the use of a traction table,including 42 males and 64 females,with the age range of 65 ～ 98 years (the median age was 78 years);and In the supine position group,67 were operated in supine position with a traction table,including 32 males and 35 females,with the age range of 66-101 years (the median age was 76 years).The anesthesia time,operative time,length of hip incision,intraoperative dominant bleeding loss,the rate of bone hook assisted reduction,hospitalization days,fracture reduction effect,fracture healing time,and postoperative complications were analyzed and compared,and the function of hip joint was evaluated according to the Harris score system.Results The anesthesia time was 59.3± 8.7 min,operative time was 46.6±6.5 min,length of hip incision was 2.9±0.9 cm,intraoperative dominant bleeding toss was 76.4±15.6 ml,and the rate of bone hook assisted reduction was (25.4％,17/67) in the lateral position group,while the anesthesia time was 62.6±7.4 min,operative time was 51.4±9.7 min,length of hip incision was 4.2±1.1 cm,intraoperative dominant bleeding loss was 105.3±17.4 ml,and the rate of bone hook assisted reduction was (25.4％,17/67) in the supine position group.These of the lateral position group were less than those of the supine position group,and the difference was statistically significant (P ＜ 0.05).The overall incidence of complications was 24.53％ (26/106),lateral cortical disruption of the greater trochanter accompanied with extravasation of the nail point was 3.77％ (4/106),the incidence of deep venous thrombosis was 4.72％ (5/106) and the incidence of skin contusion was 0.94％ (1/106) in the lateral position group,while those of the supine position group were 56.71％ (38/67),11.94％ (8/67),10.45％ (7/67),and 10.45％ (7/67).Numerical analysis of the lateral position group was less than those of the supine position group,and the difference was statistically significant (P ＜ 0.05).The hospitalization days (t=1.75,P=0.081) and the effect of fracture reduction (x5=0.202,P=0.042),fracture healing time (t=-1.47,P=0.145) and Harris score of hip function (t=1.03,P=0.305) were not statistically different (P ＞ 0.05) between the two groups.Conclusion Fixation of intertrochanteric fractures using PFNA in the lateral position without a traction table has more advantages than those of in supine position with traction table and is worthy of promotion and application in basic hospitals.

Fracture-related infections are a major problem that plagues many orthopedic surgeons.As their diagnosis is often doubtful, treatment time-consuming, healing prolonged and expenditure huge, they se-riously damage the physical and mental health of patients.In view of the differences in injury mechanism, injury severity, bacterial origin and onset time in patients with fracture-related infection, it is particularly important to standardize the clinical collection of specimens to increase positive rate of bacterial culture and detection rate of pathogenic bacteria.This article expounds on preparation, timing, location, type, quantity and post-processing in specimens’ collection, hoping that a fine understanding of standardized procedures in specimens’ collection may better serve clinical treatment.

Objective To compare the clinical effects of conventional incision versus oblique mini-incision in the treatment of displaced midshaft clavicular fractures. Methods A prospective randomized controlled trial was performed between August 2014 and August 2016 in 79 patients with acute displaced midshaft clavicular fracture. They were randomly divided into 2 groups to receive either conventional incision or oblique mini-incision treatment. In the oblique mini-incision group, there were 37 cases, 20 males and 17 females, with an average age of 37.4 ± 13.2 years. By the Robinson fracture classification, there were 9 cases of type 2A2, 16 ones of type 2B1, and 12 ones of type 2B2. In the conventional incision group, there were 42 cases, 22 males and 20 females, with an average age of 38.2 ± 14.5 years. By the Robinson fracture classification, there were 9 cases of type 2A2, 19 ones of type 2B1, and 14 ones of type 2B2. We recorded operation time, intraoperative blood loss, scar size, clinical complications and fracture healing time. Functional assessments were conducted at l2 months using the Disabilities of the Arm, Shoulder and Hand (DASH) and Constant-Murley scores, and a questionnaire on numbness, scar appearance and satis-faction. Results Only 58 patients finished a complete follow-up. The preoperative general data showed no statistical significance between the 2 groups (P > 0.05). All the 58 patients were followed up for 13 to 24 months (average, 15.3 months). There were no significant differences between the 2 groups in operation time, fracture healing time, the DASH or Constant-Murley score, or clinical complications (P> 0.05). However, the intraoperative blood loss in the oblique mini-incision group (20.8 ± 10.7 mL) was significantly less than that in the conventional incision group (41.6 ± 7.6 mL), the scar size in the former (3.6 ± 1.6 cm) significantly shorter than that in the latter (10.3 ± 2.6 cm), and the rate of symptoms of residual injury to the supra-clavicular nerve in the former (10.7%, 3/28) significantly lower than that in the latter (43.3%, 13/30) (P <0.05). Moreover, the oblique mini-incision group was significantly better than the conventional incision group in numbness on the shoulder or anterior chest, scar appearance and satisfaction. Conclusions The oblique mini-incision may be advantageous over the conventional incision in intraoperative blood loss, scar size and appearance, iatrogenic supraclavicular nerve damage and satisfaction. However, the 2 incisions may lead to similar functional recovery of the shoulder.

Objective:To investigate the clinical efficacy of the femoral neck system (FNS) after the reduction of the Schanz screw combined with the rod stick technique in the treatment of valgus-impacted femoral neck fracture.Methods:A retrospective analysis of clinical data from 66 patients with valgus-impacted femoral neck fractures from December 2019 to November 2021 has been performed. All patients were treated with the Femoral Neck System. Auxiliary reduction group (using the Schanz screw and rod stick technique), including 32 cases, 9 males and 23 females with an average age of 52.7±12.0 years (range, 28-77 years); 14 patients on the left side and 18 patients on the right side; body mass index 23.1±2.6 kg/m 2. Manual reduction group (using the traditional Flynn closed reduction technique), including 34 cases, 18 males and 16 females with an average age of 52.1±12.7 years (range, 26-75 years); 18 patients on the left side and 16 patients on the right side; body mass index 23.4±2.3 kg/m 2. The surgery time, intraoperative blood loss, complications, and Harris hip score at the last follow-up were collected and compared between the two groups. Preoperative and postoperative abduction angle and posterior tilt angle were measured in the anterior-posterior and lateral positions of the hip, as well as the length of the femoral neck shortening at the last follow-up. Pearson analysis was used to evaluate the correlation between preoperative and postoperative abduction angle and posterior tilt angle, the length of femoral neck shortening, and Harris hip score. Results:There were no significant differences in baseline data such as gender, age, side of injury, height, weight, and body mass index, and the surgery time and intraoperative blood loss between auxiliary reduction group and manual reduction group ( P>0.05). All 66 cases with a mean follow-up of 20.4 months (ranges 12-29 mouths). The fracture healing time was 5.0±0.9 weeks in the auxiliary reduction group and 4.9±0.8 weeks in the manual reduction group ( t=-0.41, P>0.05). There were no significant statistical difference in the preoperative abduction angle and preoperative posterior tilt angle between the auxiliary reduction group and the manual reduction group ( P>0.05). The postoperative abduction angle and posterior tilt angle of the auxiliary reduction group (1.8°±3.1°, 1.2°±3.0°) were significantly lower than those of the manual reduction group (13.7°±6.5°, 6.8°±4.1°, t=-9.55, P<0.001; t=-7.42, P<0.001). Preoperatively, 61 cases (92%) were associated with a posterior tilt of the femoral head, and 30 (46%) of them had a posterior tilt angle of more than 10°. The length of femoral neck shortening at the last follow-up and the moderate and severe femoral neck shortening rate postoperatively in the auxiliary reduction group (1.4±2.1 mm, 0, and 3%) were significantly lower than those in the manual reduction group (8.1±4.8 mm, 38%, and 32%, P<0.05). Harris hip score at the last follow-up in the auxiliary reduction group 91.1±4.5 was significantly higher than those in the manual reduction group 85.5±5.4 ( t=4.54, P<0.001). The postoperative abduction angle and length of femoral neck shortening showed correlations with the Harris hip score respectively ( r=-0.551, -0.743; P<0.001). In the auxiliary reduction group, 1 case of broken temporary fixed Kirschner wire was removed by nucleus pulposus forceps, and the fracture site healed after surgery. In 2 cases, the Schanz screw loosened and pulled out during the reduction process, and the successful reduction was achieved after increasing the depth of the Schanz screw insertion, and no peri-Schanz screw fracture occurred. After surgery, 3 cases (1 case in the auxiliary reduction group and 2 cases in the manual reduction group) developed avascular necrosis of the femoral head (18 months, 18 months, and 2 years after surgery, respectively), femoral head collapse and severe shortening of the femoral neck, all of which underwent total hip arthroplasty. Conclusion:FNS after the reduction of the Schanz screw combined with the rod stick technique in the treatment of valgus-impacted femoral neck fracture has the advantages of effectively correcting preoperative abduction angle and posterior tilt angle and reducing the length of femoral neck shortening, and it can obtain satisfactory short and medium-term clinical efficacy.

Objective:To explore the changes in the expression of Tau protein and phosphorylated Tau (p-Tau) protein in neurons after spinal cord ischemia-reperfusion injury (SCII).Methods:Ninety-six healthy adult SD rats were randomly divided into a sham operation group ( n=48) and a SCII group ( n=48). Based on the reperfusion time of 3 h, 6 h, 12 h, 24 h, 48 h and 72 h, the SCII group was divided into 6 subgroups ( n=8 per subgroup). Immunohistochemical staining was used to observe the apoptosis of spinal cord neurons in the L 4-L 5 segments and the expression of Tau protein and p-Tau protein. Results:In the sham operation group, the neuron cells were intact, mainly concentrated in the gray matter. Tau protein was seen in a small number of neuron cells, and a small amount of filamentous p-Tau protein in the pernucleus and cytoplasm. There was no significant difference between Tau protein and p-Tau protein expression in neurons at each time point ( P>0.05). In the SCII group, scattered Tau protein was seen in the apoptotic cells while there was a strong positive expression of Tau protein in the non-apoptotic cells. The expression of Tau protein in the SCII group gradually increased after injury, reaching a peak at 48h and plateauing at 72 h, and was significantly different between any 2 time points (except for 72 h) ( P<0.05). In the SCII group, the positive expression of p-Tau protein was observed in the cytoplasm of the apoptotic cells in strips and sheets. It increased rapidly within 6 h but did not change significantly after 6 h, showing no significant difference between any 2 time points afterwards ( P>0.05). There was a statistically significant difference in the expression of Tau protein and p-Tau protein between the SCII group and the sham operation group at each time point ( P<0.05). Conclusion:It is hopeful to reduce the severity of spinal cord injury by regulating the expression of Tau protein and p-Tau protein within 6 to 48 hours after SCII.