Background:Both hormonal therapy (HT) and maintenance capecitabine monotherapy (MCT) have been shown to extend time to progression (TTP) in patients with metastatic breast cancer (MBC) after failure of taxanes and anthracycline?containing regimens. However, no clinical trials have directly compared the effcacy of MCT and HT after response to ifrst?line capecitabine?based combination chemotherapy (FCCT) in patients with hormone receptor (HR)?positive and human epidermal growth factor receptor 2 (HER2)?negative breast cancer. Methods:We retrospectively analyzed the charts of 138 HR?positive and HER2?negative MBC patients who were in non?progression status after FCCT and who were treated between 2003 and 2012 at the Cancer Institute and Hospital, Chinese Academy of Medical Sciences, in Beijing, China. The median number of ifrst?line chemotherapy cycles was 6 (range, 4–8); combined agents included taxanes, vinorelbine, or gemcitabine. Of these 138 patients, 79 received MCT, and 59 received HT. Single?agent capecitabine was administered at a dose of 1250mg/m2 twice daily for 14days, followed by a 7?day rest period, repeated every 3weeks. Of the 59 patients who received HT, 37 received aromatase inhibitors (AIs), 8 received selective estrogen receptor modulators (SERMs), and 14 received goserelin plus either AIs or SERMs. We then compared the MCT group and HT group in terms of treatment effcacy. Results:With a median follow?up of 43months, patients in the HT group had a much longer TTP than patients in the MCT group (13 vs. 8months,P=0.011). When TTP was adjusted for age, menopausal status, Karnofsky performance status score, disease?free survival, site of metastasis, number of metastatic sites, and response status after FCCT, extended TTP was still observed for patients in the HT group (hazard ratio: 0.63; 95% conifdence interval: 0.44–0.93;P=0.020). We also observed a trend of overall survival advantage for patients in the HT group vs. patients in the MCT group, but the difference was not signiifcant (43 vs. 37months,P=0.400). In addition, patients in the HT group gen?erally tolerated the treatment well, whereas patients in the MCT group experienced grades 3–4 adverse events, the most frequent of which were hand?foot syndrome (15.8%) and hematologic abnormalities (7.6%). Conclusion: For HR?positive and HER2?negative MBC patients, HT might be considered a treatment after response to FCCT but prior to MCT as a long?term administration.

Professor -'s experiences in treatment of intellectual disability with acupuncture at " line" is summarized. In the pathogenesis of intellectual disability, the insufficiency of essential and the malnutrition of the prenatal essence and the postnatal essence result in the insufficiency of of five organs. Persistent sickness consumes and injures blood. The insufficiency of and blood causes the dysfunction of transportation and transformation. Hence, phlegm is produced and mixed with stasis. This disease is localized in the brain and closely related to heart, kidney, spleen and stomach. The " line" was created on the base of the theory of street and the international standard of scalp acupuncture. The satisfactory effect has been achieved in the children with intellectual disability treated by this therapeutic method. In clinical treatment, the syndrome differentiation of the disease should be integrated with the symptoms.
Acupuncture Points ; Acupuncture Therapy ; Child ; Drugs, Chinese Herbal ; Female ; Humans ; Intellectual Disability ; therapy ; Pregnancy

Objective To analyze the epidemiological characteristic of stroke incidence and mortality in Chongqing, and to provide suggestions for targeted prevention and control of stroke. Methods Data of reported cases of ischemic stroke (I63), hemorrhagic stroke (I61-I62), subarachnoid hemorrhage (I60), and unclassified stroke (I64) in Chongqing in 2018 was collected. SPSS 25.0 was used to calculate the incidence, age-standardized incidence rate (ASIR), mortality, age-standardized mortality rate (ASMR) and proportion of stroke. The incidence and mortality of stroke were compared by Chi-square test between males and females, and between central urban areas and suburban counties. Results In 2018, the incidence and ASIR of stroke were 294.61/105 and 222.43/105 in Chongqing, respectively. The mortality and ASMR of stroke were 116.34/105 and 85.81/105. The incidence, ASIR and proportion of ischemic stroke were 186.63/105, 139.17/105 and 63.35%, respectively. The incidence of ischemic stroke in male was higher than that in female (χ²=18.52, P<0.001). The incidence of ischemic stroke in central urban areas was higher than that in suburban counties (χ²=29.50, P<0.001). The mortality of ischemic stroke in male was higher than that in female (χ²=6.67, P=0.010). The mortality of ischemic stroke in suburban counties was higher than that in central urban areas (χ²=17.55, P<0.001). The incidence, ASIR and proportion of hemorrhagic stroke were 78.15/105, 60.44/105 and 26.53%, respectively. The incidence of hemorrhagic stroke in male was higher than that in female (χ²=27.64, P<0.001). The incidence of hemorrhagic stroke in suburban counties was higher than that in central urban areas (χ²=18.60, P<0.001). The mortality of hemorrhagic stroke was the highest among all subtypes of strokes. The mortality, ASMR and proportion of hemorrhagic stroke was 64.44/105, 48.28/105 and 55.39%, respectively. The mortality of hemorrhage stroke in male was higher than that in female (χ²=23.46, P<0.001). The mortality of hemorrhage stroke in suburban counties was higher than that in central urban areas (χ²= 43.57, P<0.001). Conclusion The incidence and mortality of stroke in Chongqing were lower than the national average levels. The incidence of ischemic stroke was higher than that of hemorrhage stroke. The mortality of hemorrhage stroke was higher than that of ischemic stroke. Men and suburban counties were the focus of stroke prevention and control in Chongqing.

Objectives: To investigate the prevalence and associated risk factors of tinnitus in Sichuan and Chongqing. Methods: We designed a tinnitus epidemiological questionnaire. The multi-stage stratified cluster random sampling methods was applied to obtain study subjects in six areas (Nanchong, Jiangjin, Fengdu, Yunyang, Suining and Ya'an), which were selected for epidemiological investigation. Home visit completion of epidemiological questionnaires was conducted. The trained investigators guided the respondents to fill in the tinnitus epidemiological questionnaires, and the epidemiological status of six areas on prevalence and risk factor was investigated. SPSS 22.0 software was used for statistical analysis. Results: Sampling population were 10 289, in which 9 273 were valid questionnaires. There were 4 281 males and 4 992 females, with an average age of 47.3 years, among which 34.83% (3 230/9 273) had tinnitus. 3.99% (370/9 273) were diagnosed with bothersome tinnitus. In a multivariable logistic regression mod, the following factors were associated with onsetting of tinnitus: sleep disorder [Odds Ratio(OR)=3.74] and noise exposure(OR=1.99). The risk of disease was lowest in the age of 30-40 years old, while the risk of disease was higher for people under 30 and over 40. In another multivariable logistic regression mode, the following factors were associated with having bothersome tinnitus: older people were more likely to suffer from tinnitus, sleep disorders (OR=4.68) and noise exposure (OR=1.56). Conclusions: The prevalence of tinnitus in Sichuan and Chongqing is about 34.83%, but most of the tinnitus is short-lived and has low loudness, which will not affect the patients. Only a small number of patients with tinnitus (3.99%) persist and affect their health and need treatment. The occurrence and exacerbation of tinnitus may be related to sleep, age, and noise exposure.
Adult ; Aged ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Surveys and Questionnaires ; Tinnitus/epidemiology*