Crohn's disease (CD) is a chronic granulomatous disease with unknown causes, and its incidence shows a rising trend in China. So far there is no way for the complete cure of the disease. Conventional drug therapy has many limitations. The appearance of biological agents brings new treatment options for CD and also initiates a debate over "Step-up" versus "Top-down" strategies. Rational nutrition supplement plays an important role in the comprehensive treatment of CD. This paper reviews the efficacy of conventional drugs, new progress in drug therapy, roles and status of nutritional support, and new treatment strategies for CD.

In the treatment of parenteral nutrition(PN) of preterm infants, parenteral nutrition associated cholestasis(PNAC) is the most common complication. However, the mechanisms of how this complication happens are unknown. This paper summarizes the research reports about PNAC both at home and aboard in recent years and raises various precautions on premature birth avoiding, reasonable feeding, PN projects optimizing and so on.Ursodeoxycholicacid is the first-line drug in the current treatment for PNAC.

Non-Hodgkin's lymphoma (NHL) is a heterogeneous disease from various resources and biological characters. Currently, about 90 ％ of NHL is relative to chromosomal abnormalities. This review emphasizes chromosomal abnormalities in non-Hodgkin's lymphoma, which can not only help understanding NHL genesis,but also is useful for diagnosis on early stage and proper treatment.

Circular RNA (circRNA) is widely found in various species' cells.They have several characteristics including structural stability,high expression and expression in a tissue-specific manner.Recent studies have demonstrated that circRNA is a member of competing endogenous RNA (ceRNA).CircRNA regulate the expression of related RNA molecules via binding with target microRNA (miRNA) and play an important role in gene expression and regulation.The finding of circRNAs not only expand our understanding about eucaryon and ceRNA regulation network,but also indicate that circRNA might be a new biological marker for diagnosis and has good application prospects in drug development research,and disease diagnosis and treatment.Because current research on circRNA is still very few,a brief summary about circRNA is presented in this paper for further research.

The immunopharmacological effects of anisodamine(654-2)on immune complexnephritis were examined in rabbits with acute experimental serum sickness(AESS).The results showed that activities of renal calmodulin(CaM)and cathepsin D(Cath-D)were significantly high.654-2 could inhibit CaM activity and immune complex-induced lysosomal enzyme release,and lessen immune complex glomerulonephritis at thesame time.Our findings suggest that a marked inhibition of CaM activity by 654-2 mi-ght contribute greatly to the improvement of immune complex glomerulonephritis.

Inflammatory bowel diseases (IBD) possibly lie in a dysregulated response of the intestinal mucosal immune system towards intestinal microflora under a combined action of genetic and environmental factors.Mucosal dendritic cells are assumed to play key roles in regulating immune responses in the antigen-riched intestinal environment, either by initiating immune responses or by maintaining tolerance. Defects in this regulation are supposed to lead to IBD. This paper reviews the recent research advances in the relationship between IBD and dendritic cells.

In recent years the incidence rate of tuberculosis (TB) has gone up.It was estimated that 1/3of people had asymptomatic latent tuberculosis infection globally.The current widespread use of Bacillus calmetteguerin (BCG) vaccine program against tuberculosis in children has a good preventive effect,but due to the limited duration of the immune responses induced by BCG,there also had situation of prevent failure,so researchers begin to explore new TB vaccines,such as live attenuated mutant strains,subunit vaccines and DNA vaccines,and achieved certain results.For the pure protein derivative tuberculosis skin test positive and immunosuppressed children,in addition to active immunization would also need anti-TB medicine for chemoprophylaxis.

Based on the analysis of Medical Independent Colleges,this article is trying to discuss how to set up majors innovatively,reform curriculum and teaching plans effectively By doing this,it aims to set up a bettor education model of Medical Independent Colleges with characteristics of the running of such Medical Independent Colleges.Wishing it can serve as an talent training model for the colleges of the same kind

The paper systematically elaborated the concept of corporate governance structure of public hospitals and theories in relation. In addition, it analyzed the status quo and problems existing in corporate governance structure of public hospitals in China, proposing the basic principles and the council model of corporate governance structure. The authors emphasized the following responsibilities and rights of the council, the president, and the board of supervisors in such a framework: 1) As the hospital's highest decision-maker, the council exercises the rights of ownership, playing a decisive role in hospital management; 2) the president is appointed and dismissed by the council, and authorized to run the hospital; 3) the supervisors are responsible for overseeing the council and senior management. In the end, this paper summarized the external environment required for building corporate governance structure of public hospitals.

Objective To analyze the causes and treatment measures of postoperative ulnar deviation hand deformity etiology.Methods Clinical data of 17 cases of hand injuries postoperative ulnar deviation hand deformities were retrospectively analyzed.Results 17 patients with metacarpallosteotomy miniplate fixation of four cases of angular deformity jointly carpometacarpal joint instability of joint fusion and internal fixation of eigi.t cases,the metacarpal instability for interbody fusion of five cases of Kirschner wire;all patients were discharged,length of stay from 15 to 24d,the average ( 17.6 ± 2.1 )d.Concurrent ulnar deviation a hand deformity of the main reasons:patients with the palm of your hand refers to the joint dorsal aponeurosis and the extensor tendon to the ulnar tension increases,and the inside with the palm of your hand musoles to antagonize;the metacarpal multiple fractures caused by malunion or carpal joint instability;deep palmar transverse ligament metacarpal caused by the relative instability.Concurrent ulnar deviation hand deformity in 2 to 7 months after surgery,the average (4.1 ± 1.1 ) months;index finger,middle finger,ring finger and little finger and thumb before and after treatment,the declination differences were statistically significant( t =9.3213,9.8826,9.3605,9.4561,all P ＜ 0.05 ).Follow-up for 1 to 3 years,ulnar deviation hand deformities have been effectively corrected.Conclusion The palm of your hand after crush injury complicated by ulnar deviation hand deformity have a variety of reasons,need to take surgery.