Herbicides ; poisoning ; Humans ; Occupational Exposure ; Poisons

Antihypertensive Agents ; therapeutic use ; Blood Pressure ; Humans ; Hypertension ; therapy

BACKGROUND:The power output of the human joints depends on the activation of agonists and antagonist muscles around the joints, and the antagonist muscle is involved in physical activity in a co-activated manner, thereby helping to maintain joint stability. But there are less reports on the central nervous system strategies of antagonist co-activation under different muscle contraction modes. OBJECTIVE:To observe the characteristics and differences of surface electromyography (sEMG) of agonists and antagonist muscles of the knee joints during maximal and submaximal isokinetic exercises until fatigue. METHODS:Sixteen students were enroled, who developed the right knee joint fatigue induced by the Biodex isokinetic equipment, and simultaneously sEMG activities of vastus medialis, vastus lateralis and biceps femoris were recorded by the myoelectrical equipment. The RMS (%) and mean frequency were selected to analyze sEMG characteristics. RESULTS AND CONCLUSION:In the maximal isokinetic fatigue, the peak torque was decreased by 40.3% (P < 0.05) and the sEMG activity of agonists gradualy increased and then declined, but the sEMG activity of antagonists kept constant. In the submaximal isokinetic fatigue, the peak torque was decreased by 40.0% (P < 0.05), the sEMG activity of agonists gradualy increased (P < 0.05), and however the sEMG activity of the antagonists initialy increased and then decreased. The RMS and mean frequency of vastus medialis and lateralis as antagonists at selected reciprocal contractions showed no significant changes (P > 0.05). These results suggest that in the different intensities of isokinetic fatigue, the central nervous system employs different neural strategies on agonists and antagonists.

Objective To explore the relationship of angiotensin Ⅱ (Ang Ⅱ) and atrial natriuretic peptide(ANP) with the chronic heart failure syndrome in newborn infant with congenital heart disease.Methods One hundred newborn infant with congenital heart disease(30 patients in cardiac function grade Ⅰ group;40patients in cardiac function grade Ⅱ group;30 patients in cardiac function grade Ⅲ and Ⅳ group) were enrolled and 30 cases of normal physical examination newborns with matched age and sex were selected as the control group.Concentrations of Ang Ⅱ and ANP were determined in these groups.Results Ang Ⅱ in newborn infant with congenital heart disease were significantly higher than that in normal controls,the activated Ang Ⅱ were more and more as disease severity worsen in the NYHA functional classification subgroup,among them,Ang Ⅱ increased most in grade Ⅲ and Ⅳ group ((119.19 ± 5.54) ng/L and (30.72 ± 1.34) ng/L,P ＜ 0.01).Ang Ⅱ was significantly correlated with cardiac function classification (r =0.85,P ＜0.01).ANP in newborn infant with congenital heart disease were higher than that in normal controls,and ANP also increased more and more obviously as disease severity worsen in the NYHA functional classification subgroup,it increased most in grade Ⅲ and Ⅳ groups ((9.00 ± 2.37) pmol/L and (1.15 ± 0.09) pmol/L,P ＜ 0.01).ANP was significantly correlated with cardiac function classification (r =0.79,P ＜ 0.01).Conclusion Ang Ⅱ and ANP are activated in newborn infant with congenital heart disease,they are closely related to the severity of the disease.So the children's cardiac function can be speculated by detecting Ang Ⅱ and ANP concentration.

Objectives To investigate the outcomes of neonatals with abnormal hepatitis B virus (HBV) serological markers. Methods Twenty-eight neonatals who had abnormal HBV serological markers and whose mothers had positive HBsAg, HbeAg and HbcAb were studied. Among them, 21 neonatals who had positive HBsAg, HbeAg and HbcAb were included in vertical transmission group;7 neonatals who had positive HbeAg, HbcAb and negative HBsAg were included in suspicious group. The quantities of HBV serological markers were determined by time-resolved immunofluorometric assay (IFMA) and the level of HBV DNA were measured by fluorescence quantitative PCR (FQ-PCR). Results Serum HBeAg and HBsAg levels in suspi-cious group were lower than those in vertical transmission group (P<0.05). The results showed that HBeAg level (0.55 ± 0.19 PEIU/ml) three months after birth was lower than that (4.02 ± 2.00 PEIU/ml) 7 days after birth in suspicious group (P<0.05). Conclusions Early interference has positive effect in mothers and neonatls with abnormal HBV serological markers.

Despite of great strides already made, China is still lagging behind Western countries in terms of scientific innovation, which is not parallel with China's economic achievement. Here I would like to summarize my experience in 30-year science research from the following two aspects: one is the motivation and source of innovation and the other is the value and implication of innovation. I will mainly focus on the relation of innovation with accidental discovery, reversed thought, long term accumulation, and challenge of the authorities. I will also discuss the great role of innovation in developing new theories, guiding medical practice,and dealing with emergencies.

OBJECTIVE: To investigate the relative factors of pharyngo cutaneou fistulas after larynx cancer and lower pharynx cancer surgery. METHOD: The clinical datas of 87 larynx cancer patients and lower pharynx cancer patients admitted were retrospectively analyzed. According to the type of postoperative complications all cases could be divided into pharyngo cutaneou fistulas group and no pharyngo cutaneou fistulas group. Thirty-eight kinds of factors,including age, clinical stage, plasma electrolytes level and type of procedure are in the multivariate analysis, and the variability indicators are in binary-regression analysis. RESULT: Eleven patients had pharyngo cutaneou fistulas (12.64%). Univariate analysis indicated that BMI, pre-operative serum potassium, operation time, cervical lymph dissection, post-operative prealbumin, post-operative hemoglobin, infection and delayed union of incision were the risk factors of pharyngo cutaneou fistulas (P < 0.05). Logistic stepwise regression analysis indicated that post-operative prealbumin and operation time were the independent risk factors. CONCLUSION To avoid pharyngo cutaneou fistulam, it is very necessary to correct electrolyte disorder and negative nitrogen balance. To shorten the operation time, to avoid incision infection and delayed union were helpfulness, too.
Cutaneous Fistula ; pathology ; Digestive System Fistula ; pathology ; Humans ; Laryngeal Neoplasms ; surgery ; Laryngectomy ; Multivariate Analysis ; Otorhinolaryngologic Surgical Procedures ; Pharyngeal Neoplasms ; surgery ; Pharynx ; pathology ; surgery ; Postoperative Complications ; Retrospective Studies

Objective: To explore influence of short-term intervention of different doses rosuvastatin on plasma levels of thrombomodulin (TM) and high sensitive C reactive protein (hsCRP) in patients with acute coronary syndrome (ACS). Methods: A total of 32 ACS patients were enrolled, randomly and equally divided into rosuvastatin 10mg group and rosuvastatin 20mg group, and another 16 patients without coronary heart disease were enrolled as normal control group. Enzyme linked immunosorbent assay (ELISA) was used to measure plasma levels of TM and hsCRP in two rosuvastatin groups before and after treatment and in normal control group at admission. Adverse drug reactions and incidence rates of cardiovascular events within one month were observed in two rosuvastatin groups. Results: Plasma levels of TM and hsCRP in two groups of ACS patients were both significantly higher than those of normal control group before treatment, P<0.001 all; compared with before treatment, there were significant decrease in levels of TM [10mg group：(54.09±52.45) μg/dl vs. (15.65±2.30) μg/dl，20mg group：(70.27±62.43) μg/dl vs. (19.86±5.49) μg/dl] and hsCRP [10mg group：(126.35±76.08) ng/ml vs. (54.85±45.30) ng/ml，20mg group：(125.35±60.29) ng/ml vs. (58.14±53.54) ng/ml] in two rosuvastatin groups after treatment 7d, P<0.01 all; But there were no significant differences in influences of two doses on plasma levels of TM and hsCRP in ACS patients, P＞0.05 all. There was no significant difference in incidence rate of adverse drug reactions between two rosuvastatin groups during follow-up (P>0.05); compared with rosuvastatin 10mg group, there was significant decrease in incidence rate of major adverse cardiovascular events（MACE）: Relapse angina pectoris (62.50% vs. 18.75%, P<0.01) in rosuvastatin 20mg group. Conclusions: Early intensive statins medication （rosuvastatin 20mg）can decrease plasma levels of thrombomodulin and high sensitive C reactive protein, and rosuvastatin 20mg/d can effectively decrease incidence rate of cardiovascular events without significant increase incidence rate of adverse drug reactions in ACS patients.

Objective To study the vasodilating effect of the acetone- extract (AE) from Cortex Mori (CM) and its vasodilating mechanism. Methods Guinea pig models with contraction of mesentery blood capillary induced by noradrenalin were used to study the in- vivo vasodilating effects of AE from CM. In- vitro effect of AE from CM on rat thoracic aortic ring was observed. The contents of nitric oxide (NO), nitric oxide synthase (NOS), constitutive NOS(cNOS) and inducible (iNOS) in plasma and aortic tissue were determined by method of nitroreductase chromatometry. Results AE from CM had vasodilating effect on the contracti on of mesentery blood capillary in guinea pigs and the contraction of rat thoracic aortic ring induced by 10? mol/L phenylephrine, even under the condition of pre- treating with glibenclamide (1 ? mol/L) or propranolol (3 ? mol/L). When the endothelium of the rat thoracic aortic ring was removed, AE from CM had not vasodilating effect but constrictive effect. AE from CM could also increase the contents of NO, NOS and cNOS in the aortic tissue and had no obvious effect on the NO content in plasma and iNOS in aortic tissue of rats. Conclusion The vasodilating mechanism of AE from CM may be related to promoting the release of NO from endothelium of blood vessel and synthesis of NOS and cNOS in aortic tissue.

Objective To observe effect mechanism of L-arginine (L-arg,a precurory substance of nitric oxide sythesis) in proveting proteinuria in adriamycin-induced nephrosis model of rats.Methods Nephrosis model of 16 rats was established by tail vein injetion with adriamycin,then the 16 rats were divided into two groups;model group and treatment group with L-arg administration (treated group),the levels of nitric oxide(NO),endothelin-1(ET-1),renal function,and pathological changes were observed in the two groups.Results The successful nephrosis model of rats was indentified with optical and electron microscope technique.Proteinuria was occurred in the two groups,but proteinuria degree in treated group was lighter than those of model group,however NO level was higher than that of model group,there was negatively correlation in the levels of NO and ET-1 between both groups,pathological alteration under electron microscope observation was obviously less in the treatment group than those of the model group.Conclusions On basis of these findings,author consider that the L-arg could reduce proteinuria output by promoting NO synthesis and suppress the ET-1 production.