1.Status of diagnosis of prostate cancer
Chinese Journal of Interventional Imaging and Therapy 2009;6(4):375-377
Early diagnosis is the key factor to improve the cure rate and the survival rate of prostate cancer. This article reviewed the main diagnostic techniques of prostate cancer and related progress in research and clinical application.
3.Efficacy and effect on related brain-gut peptides of acupoint sticking therapy for functional dyspepsia
Wei-Guang KONG ; Tian-Feng HE ; Xie-He KONG
Journal of Acupuncture and Tuina Science 2021;19(5):384-388
Objective: To observe the efficacy of acupoint sticking with Jianpi Tongjing Zhitong ointment in the treatment of functional dyspepsia due to liver-qi stagnation and spleen deficiency and its effect on serum 5-hydroxytryptamine (5-HT) and ghrelin contents. Methods: One hundred patients with functional dyspepsia due to liver-qi stagnation and spleen deficiency were divided into a treatment group and a control group by the random number table method, with 50 cases in each group. The treatment group received acupoint sticking with Jianpi Tongjing Zhitong ointment and the control group was treated with mosapride citrate orally. Patients were treated for 4 weeks as a course. The therapeutic efficacy was compared after one-course treatment and the differences in gastric emptying rate, and serum 5-HT and ghrelin contents between groups were compared before and after treatment. Results: The total effective rate was 79.6% in the control group and 89.4% in the treatment group, showing significantly different between groups (P<0.05). After treatment, the gastric emptying rate and serum ghrelin content of the two groups increased significantly, and the serum 5-HT content decreased significantly, the intra-group differences were significant (all P<0.01). After treatment, the gastric emptying rate and serum ghrelin content were significantly higher in the treatment group than those in the control group, while the serum 5-HT was significant lower in the treatment group, the inter-group differences were significant (all P<0.05). A negative correlation (r=-0.59) was observed between serum 5-HT content and gastric emptying rate, and a positive correlation (r=0.64) was observed between serum ghrelin content and gastric emptying rate, showing statistical significance (all P<0.01). Conclusion: Acupoint sticking with Jianpi Tongjing Zhitong ointment has a remarkable clinical efficacy in treating patients with functional dyspepsia due to liver-qi stagnation and spleen deficiency and is able to influence the secretion of serum 5-HT and ghrelin. Improving the gastrointestinal motility through the regulation of related brain-gut peptides is suggested as an underlying mechanism for this therapy.
4.Role of histone modification in occurrence and progress of liver diseases
Desong KONG ; Feng ZHANG ; Shizhong ZHENG
Chinese Pharmacological Bulletin 2015;(5):615-618
Histone modification participates in the occurrence and development of the diseases though affecting gene transcrip-tion activity by acetylation,methylation,phosphorylation,and other forms.It is an important field in the study of epigenetics. Numerous studies have demonstrated that histone modification plays an important role in the occurrence and development of liv-er diseases.This paper reviews the recent progress in under-standing the role and mechanisms of histone modification in alco-holic liver disease,nonalcoholic fatty liver disease,viral hepati-tis,liver fibrosis and hepatocellular carcinoma,with an aim to provide a theoretical basis for the treatment of liver diseases and drug development.
5.Hemodynamics of pulmonary arterial quantitative analysis:a comparative study of simultaneous phase-contrast MR imaging and cardiac catheterization study
Shixin CHANG ; Xiangquan KONG ; Gansheng FENG
Chinese Journal of Radiology 1994;0(06):-
Objective To assess hemodynamics of pulmonary arterial flow and to count the pulmonary artery diastolic pressure (PADP) by analysis using velocity study of main pulmonary with phase-contrast MR imaging. Methods The diameter、velocity and the maximal retrograde velocity of main pulmonary artery in 45 patients were measured with phase-contrast MR imaging and compared with cardiac catheterization. The accuracy and specificity of PADP measured with phase-contrast MR imaging were evaluated by relativity and regression analysis. Results The PADP measured with phase-contrast MR imaging was (4.82?1.24) mm Hg and that measured with right cardiac catheterization was (4.52?2.00) mm Hg in 40 patients with pulmonary regurgitation. With good correlation the correlation coefficient was 0.94(P
6.The Human Health Effects and Risk Assessment of Cyanobacterial Toxins
Fanling KONG ; Feng SHI ; Shaofeng SUI
Journal of Environment and Health 1993;0(03):-
Cyanobacterial toxins may pose a threat to human health through drinking water and recreational water exposure. The official guideline limits of cyanobacterial toxins have not been established. The human health effects, exposure routes, possible guideline limits and calculation method were introduced in the present paper. The knowledge will provide a base to undertake risk management for the toxins and will also contribute to establishing official guideline limits of cyanobacterial toxins in water and will be benefit for ensuring the safety of drinking water.
7.Experimental study on treatment of acute spinal cord injury by autologous activated Schwann cells transplantation in the rat
Shiqing FENG ; Xianhu ZHOU ; Xiaohong KONG
Chinese Journal of Orthopaedics 2001;0(08):-
Objective To observe the effect of treating acute spinal cord injury in rats by transplantation of autologous activated Schwann cells(AASCs). Methods Unilateral saphenous nerves were ligated directly, free it and culture Schwann cells 1 week later using the tissue clot method. Nerve growth factor(NGF) and brain-derived neurotrophic factor(BDNF) in medium were detected in different periods. 90 female Wistar rats[(200?30) g] were randomly assigned to 3 different study groups as follows: control group A(n=30): 20% DMEM injection; research group B(n=30): autologous Schwann cells(ASCs) transplantation; research group C (n=30): AASCs transplantation. The cells were purified before transplantion to the injuried T10 spinal cord site of rats (New York University type weight drop apparatus, NYU). The recoveries of the lower extremity were observed using Basso-Beattie-Bresnahan(BBB) locomotor scoring system and somatosensory evoked potential and motor evoked potentials(SEP & MEP). And then observe the coticospinal tract(CST) using the biotinylated dextran amine(BDA) tracing. Results BBB score was higher in research group than the control group 4 weeks after injury, the statistical difference was significant(P
8.Diagnosis and treatment of insidious infection after the long bone fracture internal fixation
Zhigang KONG ; Haiquan YU ; Wenling FENG
Orthopedic Journal of China 2006;0(22):-
[Objective]To study diagnosis and treatment of insidious infection after the internal fixation of long bone fracture.[Method]Thirteen patients with insidious infection after internal fixation of long bone fracture were treated with irrigation after debridment. Among the 13 cases 8 fractures were dislodged internal fixation and then were fixed with the external fixation. 5 fractures were remained the internal fixation and were instilled after debridment. All of the patients were given with antibiotics for 2~3 weeks after operation.[Result]All the 13 patients were followed up. The follow-ranged from 8 to 48 months with an average of 23.5 months. Among the thirteen patients 11 fractured-bone had bony union, one nonunion and one case had fistula, Infection relapsed in two patients.[Conclusion]Bone defects, fracture nonunion often occur on patients who have insidious infection after internal fixation of long bone fracture. These patients need to be operated. In slight infections fracture can be remained after debridement. Fractures with seriously infectious have to dislodge internal fixation and to be fixed with made according to its radiographic changes.
9.Value of MR/MRCP/MRA on preoperative diagonosis for patients with malignant obstruction of biliary and pancreatic duct
Chunyou WANG ; Xiangquan KONG ; Xiansong FENG
Chinese Journal of General Surgery 1993;0(02):-
Objective To evaluate the value of imaging means on preoprative diagnosis for patients with malignant obstruction of the biliary and pancreatic ducts.[WT5”HZ]Method [WT5”BZ]44 cases underwent preoperative MR/MRCP/MRA examination. The accurate rate of diagnosis was compared with that derived from B us, CT and ERCP. Results 28 of 44 cases were diagnosed as with pancreatic and periampullary carcinoma, 5 cases as with pancreatic body and tail carcinoma,11 cases as with biliary duct carcinoma. The accurate rates of MR/MRCP/MRA for tumor locating and cause were 100% and 96% respectively. Blood vessel invasion, adjacent organ infiltration and matastasis were detected preoperatively in 17 cases. In contrast, the accurate rate for tumor locating and cause were 82% and 76% with CT, 73% and 68% with B us, 96% and 84% with ERCP. [WT5”HZ]Conclusions [WT5”BZ] MR/ MRCP /MRA combined has advantage over B us, CT and ERCP in preoperative diagnosis especially for detecting organ matastasis and blood vessel infiltration. It has an important value in the establishment of tumor staging and decision making of clinical therapy.
10.Effects of tianeptine and lithium on expression of pCREB in hippocampus of chronic stress depression rats
Feng WU ; Yanqing TANG ; Lingtao KONG
Chinese Journal of Behavioral Medicine and Brain Science 2011;20(5):385-387
Objective To research the effects of tianeptine and lithium on expression of pCREB in hippocampus of chronic stress depression rats. Methods All the experimental rats were divided by random into : Group of depression,Group of tianeptine,Group of lithium and Group of control. The rats of Group of depression, Group of tianeptine and Group of lithium were applied stress for 21 days,and meanwhile Group of control had no stress. The rats of Group of tianeptine were fed with tianeptine (50 mg/kg) , Group of lithium were fed with lithium (60 mg/kg) , while another groups were fed with normal sodium of the same volume. The ethology examination was performed by using method of open-field and experiment of fluid consumption. The expression of pCREB was detected by Western-blotting method. Results After the chronic stress,the horizontal crossing numbers,the erection times,the modification times and the percentage of sacchar-consumption of the rats of Group of depression were 23.2±23.0;8. 1 ±7.2; 3.6 ±3.5 and (55.4 ±11.7)% respectively, which were less than Group of control (46.0±18.9;20.3±11.3;8.4±2.7 and (68.5 ±8.2)% ; P<0.01). The horizontal crossing numbers(28. 1 ±23.0) ,the erection times(12. 1 ± 9.4) and the modification times(5.5 ±3.2) of Group of tianeptine are less than those of Group of control (P < 0. 05), but no significant difference compared with Group of depression; the percentage of sacchar-consumption(62.7 ± 10.6) % ,Group of tianeptine was more than Group of depression (P< 0.05 ) , but no obvious difference with Group of control. The horizontal crossing numbers, the erection times, the modification times and the percentage of sacchar-consumption of Group of lithium were less than those of Group of control (P < 0.05), more than those of Group of depression but no significant difference (P > 0.05). In Westernblotting method,the level of pCREB in the hippocampus of Group of depression was less than that of Group of control (P< 0.01); that of Group of tianeptine was more than that of Group of depression (P < 0.01) but no obvious difference with Group of control; that of Group of lithium was less than that of Group of control (P<0. 01) and more than Group of depression (P<0.01). Conclusion Tianeptine could reverse the reduction of expression of pCREB in hippocampus of chronic stress depression rats and lithium partly did it.