1.A case of pulmonary interstitial fibrosis.
Chinese Journal of Pathology 2006;35(7):434-435
Antigens, CD
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metabolism
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Antigens, CD1
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metabolism
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Antigens, Differentiation, Myelomonocytic
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metabolism
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Biopsy
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Diagnosis, Differential
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Histiocytosis, Langerhans-Cell
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diagnostic imaging
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metabolism
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pathology
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Humans
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Immunohistochemistry
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Lung
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diagnostic imaging
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metabolism
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pathology
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Lung Diseases, Interstitial
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metabolism
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pathology
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Male
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Middle Aged
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S100 Proteins
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metabolism
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Tomography, X-Ray Computed
2.Silicate pneumoconiosis: a case report.
Rui-e FENG ; Hong-rui LIU ; Zhan-ping CHANG
Chinese Journal of Pathology 2006;35(7):436-436
Adult
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Antigens, CD
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metabolism
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Antigens, Differentiation, Myelomonocytic
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metabolism
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Biopsy
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Diagnosis, Differential
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Female
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Humans
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Immunohistochemistry
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Lung
;
diagnostic imaging
;
metabolism
;
pathology
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Lung Diseases, Interstitial
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metabolism
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pathology
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Silicosis
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diagnostic imaging
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metabolism
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pathology
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Tomography, X-Ray Computed
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Vimentin
;
metabolism
3.Secretory breast cancer in a 15-year-old boy: report of a case.
Yun DONG ; Ling-ling GUO ; Feng LIU ; Feng LI
Chinese Journal of Pathology 2013;42(11):768-769
Adenocarcinoma, Mucinous
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pathology
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Adenoma
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pathology
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Adolescent
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Breast Neoplasms, Male
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metabolism
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pathology
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secretion
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surgery
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Carcinoma
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metabolism
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pathology
;
secretion
;
surgery
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Diagnosis, Differential
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Humans
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Keratin-18
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metabolism
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Keratin-8
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metabolism
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Male
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Mastectomy, Modified Radical
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Proto-Oncogene Proteins c-kit
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metabolism
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S100 Proteins
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metabolism
4.Effect of the peri-implantitis on the biological function of osteoblasts obtained from the mandibles.
Hao WU ; Hong-chen LIU ; Lingling E ; Na LIU ; Bo ZHANG ; Yuxuan GAO ; Lin FENG
West China Journal of Stomatology 2014;32(2):130-133
OBJECTIVETo study the effect of peri-implantitis inflammatory microenvironment on the biological function of jaw bone osteoblasts.
METHODSPrimary mandible osteoblasts from peri-implantitis and normal tissue were isolated and cultured. Third-generation purified osteoblasts were identified and detected. The proliferative activity of osteoblasts was evaluated through MTT assay. Osteocalcin (OCN), Runx2, and collagen I (Col I) mRNA levels were examined by real-time quantitative polymerase chain reaction. OCN protein levels were determined by Western blot.
RESULTS: After 4 d of culture, the proliferative activity of osteoblasts from peri-implantitis became lower than that of normal tissue ( P <0.05). After 7 d of culture, OCN, Runx2, and Col I mRNA expression decreased ( P <0.05). The OCN protein levels also decreased ( P <0.05).
CONCLUSIONPeri-implantitis inflammatory microenvironment can decrease the proliferation and differentiation activity of mandible osteoblasts.
Bone and Bones ; Cell Differentiation ; Humans ; Mandible ; Osteoblasts ; Osteocalcin ; Peri-Implantitis ; RNA, Messenger
5.Correlation of TLR2 and TLR4 gene polymorphisms with the susceptibility and recurrence of condyloma acuminatum.
Ji-feng LIU ; Bin QU ; Xiang-dong WANG ; Qi WANG ; Xiao-xia ZHAO ; Ai-e XU
National Journal of Andrology 2015;21(8):708-712
OBJECTIVETo explore the correlation of the gene polymorphisms of Toll-like receptor 2 ( TLR2) and TLR4 with the susceptibility and recurrence of condyloma acuminatum (CA).
METHODSUsing Snapshot, we detected the gene polymorphisms of TLR2 597(T/C), 1350(T/C), 15607(A/G), and 2258(G/A) and TLR4 896(A/G) and 1196(C/T) in the peripheral blood of 140 CA patients and 105 HPV-negative controls. We made comparisons between the CA patients and controls as well as between the cases of recurrent CA and those of non-recurrence at 6 months after treatment.
RESULTSThere were 72, 48, and 20 cases of genotype TT, TC, and CC of TLR2 597 (T/C), respectively, in the CA patients, as compared with 71, 31, and 3 cases in the controls. The gene frequency of mutant C was 31. 43% in the patients, significantly higher than 17.62% in the controls (χ2 = 12.04, P < 0.01), and it was 38.68% in the recurrent cases, remarkably higher than 27.01% in the non-recurrent cases (χ2 = 4.16, P < 0.05). There were 74, 49, and 17 cases of genotype TT, TC, and CC of TLR2 1350( T/C), respectively, in the CA patients, as compared with 73, 29, and 3 cases in the controls. The gene frequency of mutant C was 29. 64% in the patients, significantly higher than 16. 67% in the controls (χ2 =11.05, P < 0.01), and it was 36.79% in the recurrent cases, markedly higher than 25. 29% in the non-recurrent cases (χ2 = 4.18, P < 0.05). There were 44, 66, and 30 cases of genotype AA, AG, and GG of TLR2 15607(A/G), respectively, in the CA patients, as compared with 26, 58, and 21 cases in the controls. There was no significant difference in the gene frequencies of mutant G between the two groups (χ2 = 0.33, P > 0.05). No mutant genes of TLR2 2508 (G/A) or TLR4 896(A/G) and 1196(C/ T) were detected in either the CA patients or the controls. Linkage disequilibrium analysis showed a tight linkage between TLR2 597 (T/C) and 1350(T/C) (D' = 1, r2 = 0.93).
CONCLUSIONTLR2 597(T/C) is tightly linked to 1350(T/C), which is correlated with both the susceptibility and the recurrence of condyloma acuminatum.
Aged ; Case-Control Studies ; Condylomata Acuminata ; genetics ; Gene Frequency ; Genetic Linkage ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Genetic ; Recurrence ; Toll-Like Receptor 2 ; genetics ; Toll-Like Receptor 4 ; genetics
8.Attempt to use heuristic teaching to cultivate students' ideation
Yu-xia LIU ; Rui-ling CHEN ; Feng-e SUN ; Feng-lin ZHU ; Chun-tao YU ; Rui-lan NG ZHA
Chinese Journal of Medical Education Research 2011;10(8):1007-1008
Heuristic teaching is propitious to cultivating students' ideation. We have used different heuristic modes for example problems, stories, contrast, associationin and so on to cultivate medical students' ideation in pathobiology and immunology teaching and acquired good effect.
9.Treatment of 21 pediatric patients with pulmonary artery sling combined with tracheal stenosis
Chang′e LIU ; Xiaoyang HONG ; Gengxu ZHOU ; Yingyue LIU ; Hui WANG ; Gang WANG ; Xiaojuan ZHANG ; Haitao GAO ; Zhichun FENG
Chinese Pediatric Emergency Medicine 2016;23(9):609-612
Objective Total 21 pulmonary artery sling( PA sling)combined with tracheal stenosis children who received treatment in our hospital were reviewed. The feasibility of treatment strategy including left pulmonary artery( LPA)re-implantation without tracheoplasty was discussed in this study. Methods From April 2009 to November 2015,a total of 21 pediatric patients received surgical treatment due to PA sling with tracheal stenosis. Six patients received LPA re-implantation and trachea intervention simultaneously. The other 15 patients received LPA re-implantation alone to relieve the trachea compression without tracheoplasty. The postoperative strategy including early extubation and CPAP ventilation was employed in PICU. Results A total of 21 PA sling with tracheal stenosis children who underwent surgical treatment in our hospital were recruited. There were 9 females and 12 males. Ages of these children were from 1 months to 10 years old,and body weights were from 2. 9 kg to 25. 0 kg. Five patients needed mechanical ventilation for severe respiratory symptoms preoperatively. Six patients received LPA re-implantation and tracheal interven-tion simultaneously. Among them,3 patients received slide tracheoplasty,and one was discharged after recov-ery. The remaining 3 patients received tracheal stent implantation,but finally died. The survival rate was 16. 7% in these patients. Fifteen patients received LPA re-implantation alone,and slide tracheoplasty was per-formed in 2 patients for extubation failure who finally died of air leakage. The survival rate of 15 patients who received LPA re-implantation alone was 86. 7%. Conclusion The strategy in LPA re-implantation alone to relieve the trachea compression without tracheoplasty and early extubation and CPAP ventilation postoperative may be an ideal treatment for the pediatric patients with PLA sling combined with tracheal stenosis.
10.Predictive value of serum iron level for in-hospital acute heart failure after acute ST-elevated myocardial infarction.
Gang YE ; . E-mail: DR.YEGANG@QQ.COM. ; Li LIU ; Jian YU ; Feng GAN ; Hong-Cheng WEI
Journal of Southern Medical University 2015;35(4):610-614
OBJECTIVETo evaluate the predictive value of serum iron level for in-hospital acute heart failure (AHF) after acute ST-elevated myocardial infarction (STEMI).
METHODSThis retrospective study involved 287 patients with STEMI stratified by quartiles of admission serum iron concentration. The incidence of AHF was assessed by serum iron quartiles. We evaluated the association of serum iron levels with B-type natriuretic peptide (BNP), cardiac troponin I (cTnI), and high-sensitivity C-reactive protein (hs-CRP) levels on admission, and analyzed the correlation of serum iron levels with in-hospital AHF, death, and duration of hospital stay.
RESULTSThe average serum iron level on admission of the 287 STEMI patients was 10.20 µmol/L (6.90-14.40 µmol/L), and the quartiles (Q) of serum iron levels were ≤6.90 µmol/L (Q(1)), 6.91-10.19 µmol/L (Q(2)), 10.20-14.39 µmol/L (Q(3)), and ≥14.40 µmol/L (Q(4)). The incidences of in-hospital AHF from Q(1) to Q(4) were 79.5%, 64.3%, 50.0% and 45.9%, respectively (P<0.001). Univariate logistic regression analysis showed that low admission serum iron level (Q(1)) was an independent predictor for in-hospital AHF (OR=3.358, 95%CI 1.791- 6.294, P<0.001), and multivariate logistic regression analysis showed a similar result (OR=2.316, 95%CI 1.205-4.453, P=0.012).
CONCLUSIONSA lower admission serum iron level is an independent predictor of AHF in STEMI patients during hospitalization.
Acute Disease ; C-Reactive Protein ; analysis ; Heart Failure ; blood ; diagnosis ; Hospitalization ; Humans ; Incidence ; Iron ; blood ; Myocardial Infarction ; blood ; Natriuretic Peptide, Brain ; analysis ; Predictive Value of Tests ; Retrospective Studies ; Troponin I ; analysis