Objective Investigate the research capacity and key discipline construction of 9 public hospitals of Hangzhou health system in the past three years,provide suggestions based on survey findings.Methods The questionnaire designed include following information:construction of talent team in key disciplines of medicine,laboratory infrastructure investment,research projects approval and funding,papers and monographs,work efficiency and financial income,NSF funding projects and awards,and comparison of input and output.Results Key disciplines of medicine in Hangzhou health system has more than 1 200 scientific research personnel,18 provincial or municipal key disciplines,the laboratory equipment area was more than 9 000 me and total investment in lab facilities was more than 69 million RMB,the national,provincial and municipal funded project of medical key disciplines accounted for total hospital project were 71.7％,66.1％ and 53.66％.1 842 papers in total were published in the medical key (specialized) disciplines of municipal hospital.Conclusions Hangzhou health system has invested a lot of resources in medical science and technology,but is still insufficient,and there are few ways to promote the construction of talent team in key disciplines of medicine and not many leading disciplines in the country.This situation shows that the core competitiveness is not strong,and the innovation system and management mechanism need to be improved.

Objective To explore the relationship between body mass index(BMI) and blood lipid,physical activity,blood pressure and electrocardiagram(ECG) lead V1 P wave terminal force(PTFv1).Methods A total of 1 548 heahy volunteers with no diabetes,cardiovascular disease and hypertension were assigned to the normal control,overweight or obese groups.The correlation between BMI and lipid profiles was analyzed.One hundred and ninty-five volunteers without exercise-induced asthma and emergency were required to do treadmill exercise test to analyze the correlation between physical activity score,blood maximum pressure and Ptfv1.Results BMI was significantly different by blood lipid (Cholesterol:F=7.57,P＜0.05; Triglyceride:F=73.40,P＜0.05),physical activity score(F=4.52,P＜0.05) and blood maximum pressure(F=1 1.75,P＜0.05) other than age(P＞0.05).In the three groups,treadmill exercise test was significantly different in Ptfv1(normal control group vs obese group:x2=5.67,P＜0.05; overweight group vs obese group:x2=6.17,P＜0.05).Conclusion With the increase of BMI,blood lipid and maximal systolic pressure were increased,although physical activity score was decreasing.Abnormal PTFv1 was significantly associated with BMI.increased Treadmill exercise test may be helpful in screening potential cardiovascular disease among high risk obesity populations.

Objective To study the effects of ginsenosides (GS) on spontaneous sleep architecture and Cortical EEG power spectrum. Methods 24 adult SD rats were randomly divided into the control, GS 10 and 100mg/kg groups ( n = 8). Rats were instrumented with sleep-wake recording electrodes. After recovery from surgical operation,rats were orally administered GS 10 and 100mg/kg or distilled water once per day for 6 days. On GS administration day 1 and 6,Polygraphic signs of undisturbed sleep-wake activities were recorded for 12 h after GS administration. Results On GS administration day 1 ,only 100mg/kg GS increased significantly total sleep and the non-rapid eye movement ( NREM ) sleep but decreased wakefulness [(9.40 ± 0.88 ) h, ( 8.00 ± 1. 21 ) h,(2.46 ±0.81)h s (7.55 ±1.59)h,(6.36±1.54)h,(4.38 ±1.62)h,(P＜0.01, P＜0.05, P＜0.01),respectively] ;Low and high dose GS enhanced δ-wave power of NREM sleep and wakefulness (P＜ 0.05 ) but reduced θ-wave power of wakefulness (P＜0.01) and-wave power during NREM, REM sleep and wakefulness (P ＜ 0.01 ),moreover,Low and high dose GS lowered θ-wave power of REM and NREM stage(P＜0.05 ) ,respectively. After 6days of GS administration, Low and high dose GS increased markedly total sleep(P＜0.05 ) and NREM sleep(P＜0.05 ) but decreased wakefulness (P ＜0.05 ) and sleep-wake cycles (P ＜ 0.05, P ＜ 0.01 ); moreover, Low and high dose GS enhanced δ-wave power during NREM sleep and wakefulness (P ＜ 0. 05 ) but reduced θ-wave power of wakefulness(P ＜ 0.05 ) and -wave power during NREM, NEM sleep and wakefulness (P ＜ 0. 05 ), 10mg/kg GS also lowered θ-wave power of NREM sleep (P＜0.01). Conclusion These results demonstrate that GS can regulate spontaneous sleep architecture in time dependent manner,as well as cortical EEG power spectrum in rats.

0.05).CONCLUSION:Niaoxue Mixture has a good effect on treating primary glomerular hematuria as new medicine.

Objective To obtain Hangzhou residents' awareness, understanding, demands, and intentions of health examination and explore the factors influencing health examination. Methods Totally 1 183 residents (male: 542, female: 641, aged from15 to 80 years) were investigated by mean of questionnaire which included demographic characteristics, health status, medical behavior and awareness, the subjective reasons of unwilling to take health examination, the intention of choosing an institution, and the data of questionnaire were analyzed using single factor Chi-square test and conditional logistic regression analysis. Results Single factor Chi-square test showed that the factors affecting health examination participation which have statistical significances were as follows, gender (χ2=11.61,P=0.000), age (χ2=9.09, P=0.028), residence registration (χ2=44.16,P=0.000), marital status (χ2=8.96,P=0.03), educational backgroud (χ2=17.33,P=0.000), employment status (χ2=7.97,P=0.005), personal monthly income (χ2=22.82, P=0.000), having any kinds of health insurance (χ2=16.08,P=0.000), and the health examination fees paid by company (χ2=44.78,P=0.000). Conditional logistic regress analysis showed that the related fators which affecting the peoples participating rates of taking health examination are gender (P=0.003, OR=1.782), residence registration (P=0.000, OR=2.208), personal monthly income (P=0.009, OR=1.307), taking any kinds of insurance (P=0.004,OR=2.913)and the company organizing and paying for the healthy examination or not (P=0.000,OR=1.923). Conclusion The participation rates of taking health examination were affected by the factors such as male, younger than 45 years old, divorce, temporary residents, the jobless, low educational diploma and income, not having any insurance, taking the health examinaiton at their own expense and so on.

Endothelial dysfunction was closely related with AS , NO bioavailability ( production and utilization of endothelial NO ) was decreased by oxidative stress , lipid infiltration , inflammatory factor expression , vascular tone alteration and so on , which play an important role in endothelial dysfunction .Enhanced arginine , activityand asym-metric dimethylarginine together with increased hyperhomocysteinemia all promote AS by intervening NO bioavail -ability.Diabetes mellitus, obesity, chronic kidney disease , smoking and so on also involved in AS via influencing NO bioavailability and NO level .

Adult rats were implanted with sleep-wake recording electrodes in our experiments. Polygraphic signs of undisturbed sleep-wake activities were recorded for 24 h before cocaine administration, cocaine withdrawal day 1 (acute), day 8 (subacute), and day 14 (subchronic). Western blot method was performed to examine the expression levels of adenosine receptor subtypes in hypothalamus and cerebellum. Non rapid eye movement (NREM) sleep was significantly increased during nighttime (P < 0.01) and daytime (P < 0.05) on withdrawal day 8. The increase of NREM sleep was significant during nighttime (P < 0.01) and slight during daytime on withdrawal day 14, whereas both daytime and nighttime rapid eye movement (REM) sleeps were reduced markedly (P < 0.01) on withdrawal day 8 and 14. In addition, A2A receptor level was significantly enhanced on cocaine withdrawal day 8 and day 14 (P < 0.05), whereas A1 receptor level reduced markedly on withdrawal day 14 (P < 0.05). However, compared with that in the control group, no significant changes existed among adenosine A1, A2A and A2B receptors in rat cerebellum on cocaine withdrawal day 1, day 8 and day 14. Our findings suggest that sleep disorder caused by subacute and subchronic cocaine abstinence may be associated with over-expression of adenosine A2A receptor in rat hypothalamus to some extent.
Animals ; Cocaine ; adverse effects ; Dyssomnias ; chemically induced ; Electroencephalography ; Hypothalamus ; metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Receptor, Adenosine A2A ; metabolism ; Substance Withdrawal Syndrome

Sleep disorders commonly exist and are the earliest clinical symptoms in Alzheimer's disease (AD). At present, the molecular mechanism of AD caused by sleep disorders is not clear. Recent studies have found that sleep disorders can promote the accumulation of beta amyloid (Aβ) in the brain to form amyloid plaques with toxic effects. The increased Aβ inhibits the synaptic transmission pathway and induces abnormal phosphorylation of tau protein, which eventually leads to synaptic dysfunction. In addition, the inflammatory and stress response induced by Aβ are also associated with AD. Therefore, the improvement of sleep disorders may be a new pathway for the treatment of AD, in which light therapy is proved to be particularly effective. This article reviewes the latest progresses in the influences of sleep disorders in pathogenesis and treatment of AD in recent years.

The paper presented the concept of telemedicine assistants, and analyzed their professional attributes, training modality and job description. Such scenarios as emergency telemedicine consultation, electronic ICU building, and international remote pathology consultation were taken as an example, to further elaborate the role of such assistants, for the purpose of providing patients with telemedicine services of higher quality, efficiency and convenience.

Alzheimer's disease (AD) is characterized byβ-amyloid (Aβ) deposition and tauprotein hyperphosphorylation, whereas its pathogenesis has not been fully known so far. The metabolism of Aβand tau protein is critically affected by autophagy. In the early phase of AD, Aβand tau protein can induce themselves to be eliminated via mTOR-dependent and independent autophagy pathways. In addition, transcription factors EB and apolipoprotein E4 also regulate autophagy and thus participate in the metabolism of Aβand tau protein, affecting AD progression. This review summarized the roles of autophagy in the metabolism of Aβand tau protein and the autophagy regulators closely related to AD in the recent studies.