Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Integrative Medicine ; methods ; Phytotherapy ; Shock ; therapy ; Shock, Cardiogenic ; therapy ; Shock, Septic ; therapy

Objective To investigate the infiltration of inflammatory cells and the pathogenesis of nasal polyps. Methods the nasal polyps were obtained from 42 patients undergoing nasal operations. The tissues from each patient were stained with HE and Toluidine Blue for eosiophils, lymphocyte, plasma cell and mast cell and observed under the light microscope. A mean number of the above cells were counted. All data were analyzed with the Ttest. Results Eosinophils were found predominantly in 12 polyps(28.57％). Lymphocyte infiltration was shown in the other 30 polyps (71.43％). Furthermore, many mast cells with only a few eosinophils were found in the lymphocyte infiltration polyps; the number of mast cells in these polyps were much more than those in eosinophil accumulation polyps with a very significant difference(P＜0.01). Conclusion The accumulation of eosinophils in the nasal polyps does not appear to be related to the presence of mast cells and allergy. The disorder of immunity may play an important role in the formation of nasal polyps.

The efficacy of colorectal cancer treatment is not very satisfactory.Conventional morphologic imagings are limited in the diagnosis and in the applications of multimodality treatment for colorectal cancer.18 F-fluorodeoxyglucose PET-CT can play a pivotal role in detecting metabolism changes and in the localization of lesions concurrently.It is valuable in the assessment of responses to therapy,prediction of prognosis and selecting modality management and monitoring postoperative recurrence.The right-moment and proper application of PET-CT can increase the therapeutic efficacy of colorectal cancer.

Objective To explore the diagnosis of tuberous sclerosis (TSC) combined with Langerhans cell histiocytosis (LCH) and secondary hemophagocytic lymphohistocytosis (HLH).Methods One case diagnosed of TSC combined wiht LCH and secondary with HLH in infancy was retrospectively analyzed.Results One year and 4-month-old Uyghur boy when he was 4-month-old,there was onset of infantile spasm.Gene detection was performed when he was one year old and showed the absence of the exon 3 to 10 ofTSC2 gene.The diagnosis of TSC was confirmed.Meanwhile,the boy also suffered with skin rash all around,fever,hepatosplenomegaly,and bone defect.The diagnosis of LCH was confirmed by skin biopsy.In addition,the boy was complicated HLH.Conclusions It is rarely seen that TSC combined with LCH,and secondary HLH in one case.The clinical features were complex and need to be differetiate.

Objective To explore the latent class structure and heterogeneity of posttraumatic stress disorder(PTSD) in adolescent.Methods The Chinese PTSD Checklist-Civilian Version (PCL-C) was used to assess 560 adolescent from the Wenchuan earthquake area.Latent Class Model was employed to analyze the data.Results Latent Class Analysis revealed four classes of adolescent PTSD sample:pervasive disturbance (n=115,20.5％),no disturbance (n=165,29.5％),Intermediate Symptom with high Emotional Numbing (n=188,33.6％),as well as Intermediate Symptom with low avoidance (n=92,16.4％).The proportion of boys in each subsample were 55.7％,49.7％,50.5％ and 50.4％,respectively.In addition,there was no significant gender difference of prevalence within each class (x2=1.56,P=0.669).Conclusions Four-class model best fit the data for PTSD symptoms,and different clinical intervention should be adopted.

Three-dimensional conformal radiation therapy(3DCRT) is a new physical method which can enhance the therapeutic gain factor(TGF) of radiotherapy. It can escalate the doses of local tumor and decrease the doses of normal tissue. For patients with primary liver tumors, 3DCRT can increase the local control rates, prolong patients survival and decrease the incidence of radiation-induced complications.

Objective: To study the protective effect of the total flavones in Microcos paniculata (TFMP) on the acute myocardial ischemia (AMI) induced by isoprenaline (ISO) and its mechanism. Methods: The rats were ig administered with TFMP (8, 4, and 2 mg/kg) once daily for consecutive 5 d, and the AMI rat model was established by sc injection with ISO (2 mg/kg) 1 h after the last administration. The effects of TFMP on the electrocardiogram (ECG) at different time points and the myocardial tissue pathological histomorphology dying by hematoxylin were observed; The superoxide dismutase (SOD) and malondialdehyde (MDA) levels of myocardial tissue, glutathione peroxidase (GSH-Px), lactate dehydrogenase (LDH), and creatine kinase (CK) activities in serum were detected using biochemical method. Results: Compared with the model group, the high- and mid-doses (8 and 4 mg/kg) TFMP inhibited the J spot downward of ECG during myocardial ischemia (P < 0.05), especially after 10 min of ISO injection. The myocardial injury induced by ISO was aslo improved in these two groups, the levels of LDH and CK in serum (P < 0.05) and the content of MDA in myocardial homogenate (P < 0.01) were decreased, the activities of SOD (P < 0.01) and GSH-Px (P < 0.05, 0.001) in the myocardial homogenate were increased. Conclusion: The TFMP has the apparent protective effect on AMI injury, its mechanism may be related with improving the myocardial anti-oxidative ability and decreasing the oxidative stress reaction.

Acupuncture Points ; Acupuncture Therapy ; Dilatation, Pathologic ; therapy ; Female ; Halitosis ; therapy ; Humans ; Middle Aged

OBJECTIVETo develop a solvent desorption gas chromatographic method for determination of n-pentanol in the workplace air.

METHODSn-Pentanol in the workplace air was collected with activated carbon tubes, desorbed with 2% 2-propanol in carbon disulfide, separated with a nitroterephthalic acid-modified FFAP capillary column, and detected with flame ionization detector.

RESULTSThe limit of detection was 0.2 mg/L; the lower limit of quantification was 0.6 mg/L; the linear range was 0.6-4072.0 mg/L. The minimum detectable mass concentration was 0.2 mg/m3 for 1.5 L of air sample. This method was highly repeatable. The relative standard deviations were 2.3%-5.4%. The average desorption efficiencies were 86.9%-94.2%. The absorption efficiencies were 100%. The breakthrough volume was above 8.0 mg in 100-mg activated carbon. The samples in activated carbon tubes could be stored for at least 14 days at room temperature.

CONCLUSIONThe method is feasible for determination of n-pentanol in the workplace air.

2-Propanol ; Air Pollutants, Occupational ; analysis ; Carbon Disulfide ; Charcoal ; Chromatography, Gas ; Limit of Detection ; Pentanols ; analysis ; Solvents ; Workplace

Cardiovascular diseases, like coronary heart disease and myocardial infarction, are the most common cause of death worldwide. Chinese medicines have demonstrated rich cardioprotective activities for clinical applications. Salvia miltiorrhiza, a very important component of traditional Chinese medicine, can promote blood circulation and relieve blood stasis. Salvia miltiorrhiza is widely used in treatment of cardiovascular and cerebrovascular disease such as coronary heart disease and cerebral infarction ( CI). Tanshinone II(A), the major lipophilic components extracted from the root of S. miltiorrhiza, possesses anti-atherosclerosis, anti-cardiac hypertrophy, anti-oxidant, anti-arrhythmia and so on. This paper discusses current research status of tanshinone II(A) in cardioprotective effects.
Animals ; Cardiovascular Diseases ; drug therapy ; genetics ; metabolism ; physiopathology ; Coronary Vessels ; drug effects ; physiopathology ; Diterpenes, Abietane ; therapeutic use ; Humans