1.Clinical observation on heat-sensitive moxibustion plus lactulose for postoperative constipation of mixed hemorrhoid due to spleen deficiency
Journal of Acupuncture and Tuina Science 2020;18(3):219-224
Objective: To observe the clinical effect of heat-sensitive moxibustion plus lactulose oral liquid for postoperative constipation of mixed hemorrhoid.Methods: A total of 70 patients were randomized into a treatment group and a control group, with 35 cases in each group by a random number table. Patients in the control group received lactulose oral liquid alone, while those in the treatment group received additional heat-sensitive moxibustion at Shenque (CV 8). The treatment was given once a day for 15 consecutive days. The defecation interval time, defecation duration, the scores of stool form, visual analog scale (VAS) and patient assessment of constipation quality of life questionnaire (PAC-QOL), as well as the serum substance P (SP) and nitric oxide (NO) levels were measured before and after treatment. Results: After treatment, the stool form score, defecation interval time and defecation duration in the two groups dropped significantly (all P<0.05), and they were lower in the treatment group than in the control group (all P<0.05). After treatment, the VAS scores in the two groups dropped significantly (both P<0.05), and it was lower in the treatment group than in the control group (P<0.05). After treatment, the PAC-QOL scores in the two groups dropped significantly (both P<0.05), and it was lower in the treatment group than in the control group (P<0.05). After treatment, the serum SP and NO levels in the two groups improved significantly (all P<0.05), and showed statistically significant differences between the treatment group and the control group (both P<0.05). Conclusion: Heat-sensitive moxibustion plus lactulose oral liquid can improve stool form, shorten defecation interval time and defecation duration, alleviate defecation pain, and improve quality of life (QOL) for patients with postoperative constipation of mixed hemorrhoid, which may be related to the regulation of the SP and NO levels.
2.The effect of pinacidil ischemic postconditioning protects against myocardial injury in rats
Chinese Pharmacological Bulletin 1987;0(03):-
Aim To observe the effect of pinacidil ischemic postconditioning on rat ventricular myocytes during ischemia/reperfusion.Methods Rat acute myocardical anoxia-reperfusion model was used.The cardiac function and electrophysiological properties were surveyed by isolated perfusion and patch-clamp technique,respectively.Results Compared with those in the control groups,these results demonstrated that anoxia-reperfusion groups in rats could increase PSP and-dp/dtmax markedly while LVDP,+dp/dtmax and HR decreased slightly.Significant difference was found in A/R group;while pinacidil group showed the better recovery of cardiac function after ischemia/reperfusion. using patch-clamp technique,significant difference was found in pinacidil group,including increasing mean open time and conductance value.Conclusion Ischemic postconditioning by Pinacidil(PCOS of KATP)exerts an cardioprotection effect on acute myocardial anoxia-reperfusion injury.
3.Distribution and risk factors of thyroid cancer in China
Fen DONG ; Biao ZHANG ; Guangliang SHAN
China Oncology 2016;(1):47-52
Incidence of thyroid cancer has continuously increased in the last three decades globally. A similar trend of thyroid cancer incidence appeared in China. New cases and deaths of thyroid cancer in China accounted for 15.6% and 13.8% of the global new cases and deaths in 2012. The incidence in East China was the highest while that in Middle China was the lowest. Thyroid cancer was more common in urban areas than in rural counterparts. The incidence was substantially higher in female patients than male. Thyroid cancer occurred most commonly in middle age. Radiation exposure, iodine suffciency or deifciency, sex hormone and genetic mutations were risk factors for thyroid cancer. To prevent it, potassium iodide should be taken to prevent radiation fallout in nuclear accidents, unnecessary exposure to radiation from medical imaging is reduced, iodine surveillance system is improved and appropriate standards for iodized salt are established.
4.Significance of positive expressin of bcl-2 and bax in osteoarthritis in rabbit chondrocyte
Si-Jian LU ; Ling SHAN ; Hua-Dong ZHANG ; Fen-Fen WANG ;
Chinese Journal of Rheumatology 2003;0(07):-
Objective To research the significanec of genes bel-2 and bax in chondrocyte apoptosis in experimental osteoarthritis in rabbits.Method Twelve New Zealand rabbits divided into two groups at random:model group and control group.Model group with osteoarthritis was duplicated by immobilizing with gypsum at extension position in right hind limb of rabbits.Rabbits of model group were executed after 6 weeks and chondrocytes were taken.Positive expression rate of bcl-2 and bax mRNA was measured by immunohisto- chemistry and Terminal deoxynucleotidyl transferase mediated dUTP nick end labeling(TUNEL).Results Positive expression rate of mRNA in bel-2 and bax of model group was obviously more than control group(P<0.05).According to immunohistochemistry,and grey grade of positive expression of protein in bcl-2 and bax of chondrocytes in model group was lower and positive expression rate was gigher compared with control group (P<0.05,P<0.01).bcl-2 and bax of model group were lower than control group(P<0.05).Conclusion Genes bcl-2 and bax participate and thus accelerate chondrocyte apoptosis of osteoarthritis together.
6.Comparison of efficacy of remifentanil combined anesthesia and fentanyl or sufentanil combined anesthesia in patients undergoing cardiac surgery: a Meta-analysis
Zhaoduan LI ; Fen ZHOU ; Yumiao YAN ; Shuan DONG ; Jianbo YU
Chinese Journal of Anesthesiology 2012;32(7):860-862
Objective To compare the efficacy of rcmifentanil combined anesthesia and fentanyl or sufentanil combined anesthesia in patients undergoing cardiac surgery.Methods We searched the Coehrane library,PubMed,EMBASE,OVID and Chinese Biomedical Database for prospective randomized controlled trials involving the comparison of the efficacy of remifentanil combined anesthesia and fentanyl or sufentanil combined anesthesia in patients undergoing cardiac surgery.The quality of the studies was evaluated by the method recommended by Cochrane Collaboration.Evaluation indexes included the mechanical ventilation time after operation,duration of stay in hospital,and level of cardiac troponin,mortality,requirement for positive inotropic drugs and incidence of hyperalgesia and myocardial infarction during perioperative period.Meta-analysis was conducted using the RevMan 5.0 software.Results Sixteen prospective randomized controlled trials involving 1473 patients were included in our Meta-analysis.The patients were divided into 2 groups:fentanyl or sufentanil group ( n =644) and remifentanil group ( n =573).Compared with fentanyl or sufentanil group,the mechanical ventilation time after operation and duration of stay in hospital were significantly shortened,the level of cardiac troponin during the perioperative period was significantly decreased and the requirement for positive inotropic drugs during the perioperative period was significantly reduced ( P < 0.05),and no significant change was found in the incidence of hyperalgesia or mortality of myocardial infarction during the perioperative period in remifentanil group ( P > 0.05 ).Conclusion The efficacy of remifentanil combined anesthesia is better than that of fentanyl or sufentanil combined anesthesia in patients undergoing cardiac surgery.
7.Clinical observation on Ahmed glaucoma valve implantation for teenagers with refractory glaucoma
Dong-Dao, SONG ; Li, TANG ; Fen-Ming, LIN
International Eye Science 2016;16(6):1153-1155
?AIM:To observe the clinical effect of Ahmed glaucoma valve ( AGV ) implantation for teenagers with refractory glaucoma.?METHODS: Twenty-seven patients ( 27 eyes ) with refractory glaucoma were treated with AGV implantation in our hospital from October 2012 to October 2014. The patients were followed up for 12mo. The success rate of the operation, postoperative intraocular pressure, the best corrected visual acuity, as well as complications were recorded.?RESULTS:The success rate of the operation was 85%. The intraocular pressure of the 27 patients decreased from 48. 3 ± 8. 3mmHg before operations to 21. 4 ± 8. 1mmHg(P<0. 05). Visual field defect was -23. 7±4. 1dB before operations, - 27. 5 ± 4. 7dB at 12mo after operations, and the difference was statistically significant (P<0. 05). There was 85% patients with improved or unchanged vision. Early postoperative complications included shallow anterior chamber ( 5 eyes, 19%) , transient high intraocular pressure ( 3 eyes, 11%) and anterior chamber hemorrhage ( 4 eyes, 15%) , drainage tube obstruction (1 eye, 4%), anterior chamber silicone tube in poor position ( 1 eye, 4%) . There was no ambiopia, drainage erosion and exposed, plate leaked out, choroidal detachment, immune rejection of graft and other complications. Long - term complications included dyscoria ( 8 eyes, 30%) , the back of the plate packed(3 eyes, 11%).?CONCLUSION:AGV implantation is characterized by a high success rate, simple operation, less complications and is an effective treatment for refractory glaucoma in adolescents.
8.The Significance of Discussing-mode Education in Medical Microbiology
Xin LIU ; Bo-Fen ZHANG ; Yuan ZHOU ; Wei DONG ;
Microbiology 1992;0(06):-
Medical microbiology is basic course of medicine.In order to improve teaching quality,we employ discussing-mode education in microbiology.This education style can not only enlighten and train poly-directional thought ability,capacity of bringing forth new ideas and pioneering spirit,but draw close the distance between students and modern life science,which make microbiological course become beginning of exploring microbiology.The employment of education style of discussing microbiology new advance is effective pathway of exploring most suitable high-quality person of talent training.
9.Diagnosis and treatment of pancreas head tumor:a report of 277 cases
Zhengming LEI ; Jing LI ; Cunhong FEN ; Kai HE ; Dong XIA ;
Chinese Journal of General Surgery 2001;0(10):-
Objective To investigate the diagnosis and treatment of tumor of the head of pancreas(THP). Methods The clinical data of 277 cases of THP were restrospectively reviewed. All patients were diagnosed by US,CT, gastroenteric barium meal and /or operation. A comparison was made in 80 cases , who underwent pancreatoduodenectomy were divided into group A(41 patients operated during1982-1995) and group B(39 patients operated after January,1996) . Results 194 patients underwent surgical treatment,including explore laparotomy in 28,bilioenterostomy or T tube drainage in 86,pancreatoduodenectomy(PTD) in 80.Among 80 cases treated with PTD, the operation time,blood loss volume and blood transfusion volume during operation, and serious postoperative complication occurring rate in group A were significantly higher than those in group B(all P 0.05 ).The follow up results were as follows:the average survival time was (4.07 ?1.80) months in patients with bile external drainage, and (8.28 ?2.31) months in hepatojejunostomy,(P
10.Pseudoangiomatous variant of spindle cell lipoma: report of a case.
Bing-wei DONG ; Xiao-yan MA ; Hui-nü HE ; Fen-juan ZHANG
Chinese Journal of Pathology 2013;42(5):343-344
12E7 Antigen
;
Antigens, CD
;
metabolism
;
Antigens, CD34
;
metabolism
;
Cell Adhesion Molecules
;
metabolism
;
Diagnosis, Differential
;
Head and Neck Neoplasms
;
metabolism
;
pathology
;
Hemangioma
;
pathology
;
Humans
;
Lipoma
;
metabolism
;
pathology
;
Liposarcoma, Myxoid
;
pathology
;
Male
;
Middle Aged
;
S100 Proteins
;
metabolism
;
Soft Tissue Neoplasms
;
metabolism
;
pathology