Objective To evaluate the effect of phlegm and blood stasis on atrial fibrillation and the effect of D-dimer on coagulation index. Methods 80 patients with phlegm and blood stasis were randomly divided into control group and treatment group, 40 cases in each group. The control group using a simple Western medicine treatment methods to Western medicine treatment based; and integrated traditional Chinese and Western medicine treatment group is based on Western medicine treatment, according to the traditional Chinese medicine syndrome, plus traditional Chinese medicine treatment, with Gualou Xiebai Banxia Decoction , Huanglian Wendan Decoction, Xuefu Zhuyu Decoction and other main plus or minus treatment, compared the two groups of efficacy, coagulation index (D-dimer). Results The total effective rate (97.5％) in the treatment group was higher than that in the control group (82.5％), the difference was statistically significant (P <0.05). After treatment, the level of D dimer in the treatment group was significantly lower than that in the control group, the difference was statistically significant (P <0.05). Conclusion The combination of traditional Chinese medicine and western medicine in the treatment of phlegm and blood stasis type is effective, and the level of D-dimer can be reduced.