1.Association of MDR1 gene C3435T and T129C polymorphism in childhood refractory epilepsy
Li GAO ; Yan LI ; Qiaofang HOU ; Yanping LIU ; Yan WANG ; Liu YANG ; Yan SUN ; Yuanning MA ; Feiyang ZHENG
Journal of Clinical Pediatrics 2014;(11):1008-1012
Objective To investigate the association between multi-drug resistant 1 (MDR1) gene C3435T and T129C polymorphism with refractory epilepsy in children. Methods A total of 260 children including 60 refractory epilepsy, 100 drug-responsive epilepsy, and 100 healthy children were enrolled. The genotypes for MDR1 polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis.The distribution of genotypes and allele frequencies of the three groups were compared. Results The distribution of TT/TC/CC genotypes and T/C allele frequencies of C3435T showed no signiifcant difference between drug-resistant patients and drug-responsive patients or normal control group (P>0.05). Drug-resistant patients were more likely to have the TC genotype and the C allele at T129C when compared with the drug-responsive patients and the normal control group (P<0.05). Conclusions T129C polymorphism of the MDR1 gene was associated with refractory epilepsy in children.
2.Research progress on continuous blood purification in the treatment of severe acute pancreatitis
Feiyang CHEN ; Zheng TAN ; Lilei LIU ; Gang ZHOU ; Xiang LI
Journal of Chinese Physician 2023;25(7):1109-1113
Severe acute pancreatitis (SAP) is a common gastrointestinal disease, often accompanied by systemic inflammatory reactions and organ dysfunction. SAP has an acute onset, severe condition, rapid progression, and poor prognosis. The development of SAP is closely related to the excessive release of inflammatory factors. In the comprehensive treatment of SAP, continuous blood purification (CBP) can clear inflammatory mediators, improve the stability of Internal environment, improve organ function, reduce blood lipids, regulate immunity, and significantly improve the condition of SAP patients. It is an important means of treating SAP. This article reviews the research progress of CBP in the treatment of SAP.
3. Association of MDR1 gene polymorphisms with refractory epilepsy in children
Li GAO ; Xiaojing YIN ; Yan LI ; Hai XIAO ; Liu YANG ; Hongye FAN ; Hui QI ; Jun ZHANG ; Jie FENG ; Feiyang ZHENG
Chinese Journal of Medical Genetics 2019;36(11):1073-1076
Objective:
To assess the association of single nucleotide polymorphisms of multidrug resistance gene 1 (