Objective To evaluate the diagnostic value of magnetic resonance tomographic angiography(MRTA) with 3.0T scanner for neurovascular compression in patients with trigeminal neuralgia and hemifacial spasm.Methods MRTA using three-dimensional time-of-flight(TOF) sequence was performed in 52 cases with trigeminal neuralgia and 9 cases with hemifacial spasm.MR oblique sagittal and coronal images were created to display the relationship between trigeminal and facial nerves and surrounding vessels,and compared with that of operation MRA showed that.Results In 52 cases with trigeminal neuralgia,the trigeminal nerves were compressed by vessels or contacted with vessels in 46 cases at MRTA,and in 9 cases with hemifacial spasm,all trigeminal nerves showed having vascular compression or in contact with vessels.The accuracy,sensitivity and specificity of MRA in diagnosing trigeminal neuralgia and hemifacial spasm caused by vascular compression were 90.2%,96.4% and 80%,respectively,which compared with that of operation.Conclusion MRTA is sensitive to neurovascular compression,which plays an important role in diagnosing trigeminal neuralgia and hemifacial spasm.

The inverted terminal repeat (ITR) is the only cis element of AAV genome essential for rAAV rescue, replication and packaging. It is prone to mutation or loss when it is latent in host cell or in plasmid. Plasmids with different ITR types were cloned to compare the influence of ITR types on the AAV packaging and infectivity. The vector plasmids were transformed the competent SURE cells to get different colonies. The ITR types of plasmids were screened by digestion with SmaⅠ. AAV vector plasmid pScGFPud has two ITRs at both ends of AAV genome and plasmid pScGFPu has only one ITR at upstream end of AAV genome. When the two plasmids were co-transfected 293 cells to prepare rAAVs, 1.08?1013 viral particles (AAV1-GFPud) were produced from 20-dishes of 293 cells cotransfected with plasmid pScGFPud, 4.28?1012 viral particles (AAV1-GFPu) were produced from 20-dishes of 293 cells cotransfected with plasmid pScGFPu. Virus AAV1-GFPud infected 293, HeLa and NCI H446 cells more efficiently than did virus AAV1-GFPu. This suggests that defect ITRs in AAV genome is deleterious to AAV packaging and AAV infectivity and vector with complete ITRs is favorable to the yield and activity of rAAV.

Purpose: This study aimed to translate the Perinatal Infant Care Social Support (PICSS) instrument into Chinese and to verify the reliability and validity of the translated version. Methods: This study used a cross-sectional design to examine the reliability and validity of the Chinese version of the PICSS (C-PICSS). A cohort of 150 first-time mothers in China participated, attending hospital follow-up care at 6 weeks postpartum. Data were collected after obtaining informed consent from the mothers. Results: The majority of mothers were aged between 20 and 29 years, with a mean age of 26.25 (±3.90) years. An item analysis of the 19 items in the C-PICSS showed that all items had an item-total score correlation above 0.2. This resulted in a Kaiser-Meyer-Olkin value of 0.92 and a significant Bartlett’s test of sphericity (χ2=1,778.65, p<.001), confirming the suitability of the data for factor analysis. Correlation analyses revealed a strong positive relationship between infant care social support and general social support (r=.62, p<.001), and a negative relationship between infant care social support and postpartum depression (r=–. 38, p<.001). Higher scores for infant care social support were associated with reporting positive relationships with their husbands (t=3.72, p<.001) and high levels of spousal involvement (t=4.09, p<.001). In terms of structural support, spouses were identified as the primary source. Conclusion The research results indicate that C-PICSS is reliable and valid as an indicator of social support for infant care among Chinese mothers.

Purpose: This study aimed to explore the levels of postpartum fatigue, parenting stress, family support,and postpartum depression (PPD) experienced by first-time Chinese mothers and to investigatetheir impact on PPD. Methods: This cross-sectional survey involved 150 primigravida women attending postnatal checkupsin Hebi City, Henan Province, China. Demographic data and information on environmental variables(living conditions, family relationships), postpartum fatigue, parenting stress, family support(expected vs. actual level), and PPD were collected. Results: The average age of the women was 26.25 years (SD, ±3.90), with 78.7% at risk for PPD(score ≥10). Significant correlations were found between PPD and postpartum fatigue (r=.63,p<.001), parenting stress (r=.59, p<.001), and family support (r=.40, p<.001). In model 1, which examinedthe influence of women’s demographic variables on PPD, significant factors included a poorrelationship with parents (β=.24, p=.001), a poor relationship with parents-in-law (β=.18, p=.029),and a poor relationship with the husband (β=.20, p=.013). When the three research variables were incorporatedinto model 2, the factors contributing to a higher level of PPD included a poor relationshipwith parents-in-law (β=.14, p=.033), increased postpartum fatigue (β=.37, p<.001), increasedparenting stress (β=.33, p<.001), and less family support than expected (β=.12, p=.048). Conclusion The most critical factors influencing PPD include postpartum fatigue, parenting stress,poor relationships with parents-in-law, and low family support among Chinese primiparas. To mitigatePPD levels, healthcare professionals should screen mothers for depression in outpatient clinicsand offer education and counseling to both mothers and their families or companions regarding PPD.

Purpose: This study aimed to translate the Perinatal Infant Care Social Support (PICSS) instrument into Chinese and to verify the reliability and validity of the translated version. Methods: This study used a cross-sectional design to examine the reliability and validity of the Chinese version of the PICSS (C-PICSS). A cohort of 150 first-time mothers in China participated, attending hospital follow-up care at 6 weeks postpartum. Data were collected after obtaining informed consent from the mothers. Results: The majority of mothers were aged between 20 and 29 years, with a mean age of 26.25 (±3.90) years. An item analysis of the 19 items in the C-PICSS showed that all items had an item-total score correlation above 0.2. This resulted in a Kaiser-Meyer-Olkin value of 0.92 and a significant Bartlett’s test of sphericity (χ2=1,778.65, p<.001), confirming the suitability of the data for factor analysis. Correlation analyses revealed a strong positive relationship between infant care social support and general social support (r=.62, p<.001), and a negative relationship between infant care social support and postpartum depression (r=–. 38, p<.001). Higher scores for infant care social support were associated with reporting positive relationships with their husbands (t=3.72, p<.001) and high levels of spousal involvement (t=4.09, p<.001). In terms of structural support, spouses were identified as the primary source. Conclusion The research results indicate that C-PICSS is reliable and valid as an indicator of social support for infant care among Chinese mothers.

Purpose: This study aimed to explore the levels of postpartum fatigue, parenting stress, family support,and postpartum depression (PPD) experienced by first-time Chinese mothers and to investigatetheir impact on PPD. Methods: This cross-sectional survey involved 150 primigravida women attending postnatal checkupsin Hebi City, Henan Province, China. Demographic data and information on environmental variables(living conditions, family relationships), postpartum fatigue, parenting stress, family support(expected vs. actual level), and PPD were collected. Results: The average age of the women was 26.25 years (SD, ±3.90), with 78.7% at risk for PPD(score ≥10). Significant correlations were found between PPD and postpartum fatigue (r=.63,p<.001), parenting stress (r=.59, p<.001), and family support (r=.40, p<.001). In model 1, which examinedthe influence of women’s demographic variables on PPD, significant factors included a poorrelationship with parents (β=.24, p=.001), a poor relationship with parents-in-law (β=.18, p=.029),and a poor relationship with the husband (β=.20, p=.013). When the three research variables were incorporatedinto model 2, the factors contributing to a higher level of PPD included a poor relationshipwith parents-in-law (β=.14, p=.033), increased postpartum fatigue (β=.37, p<.001), increasedparenting stress (β=.33, p<.001), and less family support than expected (β=.12, p=.048). Conclusion The most critical factors influencing PPD include postpartum fatigue, parenting stress,poor relationships with parents-in-law, and low family support among Chinese primiparas. To mitigatePPD levels, healthcare professionals should screen mothers for depression in outpatient clinicsand offer education and counseling to both mothers and their families or companions regarding PPD.

Purpose: This study aimed to translate the Perinatal Infant Care Social Support (PICSS) instrument into Chinese and to verify the reliability and validity of the translated version. Methods: This study used a cross-sectional design to examine the reliability and validity of the Chinese version of the PICSS (C-PICSS). A cohort of 150 first-time mothers in China participated, attending hospital follow-up care at 6 weeks postpartum. Data were collected after obtaining informed consent from the mothers. Results: The majority of mothers were aged between 20 and 29 years, with a mean age of 26.25 (±3.90) years. An item analysis of the 19 items in the C-PICSS showed that all items had an item-total score correlation above 0.2. This resulted in a Kaiser-Meyer-Olkin value of 0.92 and a significant Bartlett’s test of sphericity (χ2=1,778.65, p<.001), confirming the suitability of the data for factor analysis. Correlation analyses revealed a strong positive relationship between infant care social support and general social support (r=.62, p<.001), and a negative relationship between infant care social support and postpartum depression (r=–. 38, p<.001). Higher scores for infant care social support were associated with reporting positive relationships with their husbands (t=3.72, p<.001) and high levels of spousal involvement (t=4.09, p<.001). In terms of structural support, spouses were identified as the primary source. Conclusion The research results indicate that C-PICSS is reliable and valid as an indicator of social support for infant care among Chinese mothers.

Purpose: This study aimed to explore the levels of postpartum fatigue, parenting stress, family support,and postpartum depression (PPD) experienced by first-time Chinese mothers and to investigatetheir impact on PPD. Methods: This cross-sectional survey involved 150 primigravida women attending postnatal checkupsin Hebi City, Henan Province, China. Demographic data and information on environmental variables(living conditions, family relationships), postpartum fatigue, parenting stress, family support(expected vs. actual level), and PPD were collected. Results: The average age of the women was 26.25 years (SD, ±3.90), with 78.7% at risk for PPD(score ≥10). Significant correlations were found between PPD and postpartum fatigue (r=.63,p<.001), parenting stress (r=.59, p<.001), and family support (r=.40, p<.001). In model 1, which examinedthe influence of women’s demographic variables on PPD, significant factors included a poorrelationship with parents (β=.24, p=.001), a poor relationship with parents-in-law (β=.18, p=.029),and a poor relationship with the husband (β=.20, p=.013). When the three research variables were incorporatedinto model 2, the factors contributing to a higher level of PPD included a poor relationshipwith parents-in-law (β=.14, p=.033), increased postpartum fatigue (β=.37, p<.001), increasedparenting stress (β=.33, p<.001), and less family support than expected (β=.12, p=.048). Conclusion The most critical factors influencing PPD include postpartum fatigue, parenting stress,poor relationships with parents-in-law, and low family support among Chinese primiparas. To mitigatePPD levels, healthcare professionals should screen mothers for depression in outpatient clinicsand offer education and counseling to both mothers and their families or companions regarding PPD.

Purpose: This study aimed to translate the Perinatal Infant Care Social Support (PICSS) instrument into Chinese and to verify the reliability and validity of the translated version. Methods: This study used a cross-sectional design to examine the reliability and validity of the Chinese version of the PICSS (C-PICSS). A cohort of 150 first-time mothers in China participated, attending hospital follow-up care at 6 weeks postpartum. Data were collected after obtaining informed consent from the mothers. Results: The majority of mothers were aged between 20 and 29 years, with a mean age of 26.25 (±3.90) years. An item analysis of the 19 items in the C-PICSS showed that all items had an item-total score correlation above 0.2. This resulted in a Kaiser-Meyer-Olkin value of 0.92 and a significant Bartlett’s test of sphericity (χ2=1,778.65, p<.001), confirming the suitability of the data for factor analysis. Correlation analyses revealed a strong positive relationship between infant care social support and general social support (r=.62, p<.001), and a negative relationship between infant care social support and postpartum depression (r=–. 38, p<.001). Higher scores for infant care social support were associated with reporting positive relationships with their husbands (t=3.72, p<.001) and high levels of spousal involvement (t=4.09, p<.001). In terms of structural support, spouses were identified as the primary source. Conclusion The research results indicate that C-PICSS is reliable and valid as an indicator of social support for infant care among Chinese mothers.

Purpose: This study aimed to explore the levels of postpartum fatigue, parenting stress, family support,and postpartum depression (PPD) experienced by first-time Chinese mothers and to investigatetheir impact on PPD. Methods: This cross-sectional survey involved 150 primigravida women attending postnatal checkupsin Hebi City, Henan Province, China. Demographic data and information on environmental variables(living conditions, family relationships), postpartum fatigue, parenting stress, family support(expected vs. actual level), and PPD were collected. Results: The average age of the women was 26.25 years (SD, ±3.90), with 78.7% at risk for PPD(score ≥10). Significant correlations were found between PPD and postpartum fatigue (r=.63,p<.001), parenting stress (r=.59, p<.001), and family support (r=.40, p<.001). In model 1, which examinedthe influence of women’s demographic variables on PPD, significant factors included a poorrelationship with parents (β=.24, p=.001), a poor relationship with parents-in-law (β=.18, p=.029),and a poor relationship with the husband (β=.20, p=.013). When the three research variables were incorporatedinto model 2, the factors contributing to a higher level of PPD included a poor relationshipwith parents-in-law (β=.14, p=.033), increased postpartum fatigue (β=.37, p<.001), increasedparenting stress (β=.33, p<.001), and less family support than expected (β=.12, p=.048). Conclusion The most critical factors influencing PPD include postpartum fatigue, parenting stress,poor relationships with parents-in-law, and low family support among Chinese primiparas. To mitigatePPD levels, healthcare professionals should screen mothers for depression in outpatient clinicsand offer education and counseling to both mothers and their families or companions regarding PPD.