0.05). ALP activity of the cells on deproteinized bone was higher than that on decalcified bone(P

OBJECTIVETo investigate the regularity of cervical lymph-node metastasis in oral squamous cell carcinoma patients and determine the treatment principle to cN0 patients.

METHODS1,024 oral squamous cell carcinoma cases who underwent neck dissection between 1980-2001 were investigated retrospectively.

RESULTSThe total rate of cervical lymph-node metastasis of oral squamous cell carcinoma was 36.62% (375/1,024), the metastasis rate of cancer in tongue, buccal, gingival, and floor of mouth was 42.82%, 31.93%, 32.76%, and 25.00%, respectively; the rate of occult metastasis was 20.94%(71/339), the incidence of occult metastasis was closely related to the location of primary lesion and T stage.

CONCLUSIONThe results in this study revealed that the therapy regime of the oral squamous cell carcinoma should be based on carefully clinical examination and compositive analysis on primary lesion related to size, location and cervical lymph-node.

Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell ; pathology ; surgery ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Mouth Neoplasms ; pathology ; surgery ; Neck Dissection ; Neoplasm Staging ; Retrospective Studies ; Tongue Neoplasms ; pathology ; surgery

OBJECTIVEThe purpose of this study was to discuss the principle in neck treatment of cN0 patients with squamous cell carcinoma of buccal mucosa.

METHODS101 patients of squamous cell carcinoma of buccal mucosa at the stage of cN0, who had hospitalized in West China College of Stomatology, Sichuan University from 1980 to 2000, were investigated retrospectively. All the patients received a comprehensive therapy consisting of surgical procedures combined with chemotherapy and radiotherapy. The combining radical therapy of buccal, mandible and neck was the main surgical method. Lymph nodes were cleared after operation and examined by pathological method. The patients had been followed up for more than 3 years.

RESULTS17 patients had lymph nodes metastasis, the occult metastasis (OM) rate was 16.83%. It increased in the high stage of original lesion, the OM rate of T3 and T4 was 18.18% and 52.00%, respectively. The metastasized lymph nodes were mainly located in submandible and superior deep cervix lymph nodes, their respective metastasis rate was 41.18% and 29.41%.

CONCLUSIONThe rate of occult metastasis of squamous cell carcinoma of buccal mucosa is high, and then we should adopt actively selective neck dissection for the cN0 patients of squamous cell carcinoma of buccal mucosa.

Carcinoma, Squamous Cell ; surgery ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Mouth Mucosa ; surgery ; Mouth Neoplasms ; surgery ; Neck Dissection ; methods ; Neoplasm Staging ; Retrospective Studies