Kang Wei Granules which can strengthen the spleen, replenish Qi, clear away heat and remove dampness was used to treat 288 cases of correlative gastric disease infected by pyloric helicobacterium. Seventy-four cases were treated with triple therapy (Bismuth being the mainly ingradient) as control group. Results indicated that the treatment group was significantly superior to the control group in improvment of main symptoms, especially for the types of deficiency of spleen and stamach, and internal accumulation of dampnes-heat (P 0. 05). It is suggested that Kang Wei Granules has a better clinical therapeutic effect for treatment of correlative gastric disease infected by pyloric helicobacterium.