Abstract: Objective　To investigate the clinical manifestations, diagnosis, treatment and prognosis of COVID-19-associated multisystem inflammatory syndrome in children (MIS-C) with multisystem organ failure, and to analyze the differences between the syndrome resembling Kawasaki disease and Kawasaki disease. Methods We report a case of child diagnosed with SARS-CoV-2 infection who developed MIS-C with multi-organ failure. Literature was reviewed to further discuss clinical symptoms, diagnosis, treatment, and prognosis of MIS-C. Results The patient 's condition progressed rapidly and was severe, with acute kidney injury at admission, presenting with urine output of 0 mL in 8 hours, serum creatinine of 675.1 μmol/L, urea nitrogen of 38.2 mmol/L, creatine kinase 4 932 U/L, along with continuously elevated serum amylase, peaking at 5 809.7 U/L, aspartate aminotransferase of 995 U/L, alanine aminotransferase of 240 U/L, and frequent vomiting. The patient was categorized as critically ill. The confirmed patient with MIS-C was managed in pediatric intensive care units (PICU), received early continuous blood purification, jejunal tube feeding, and combined treatment with intravenous methylprednisolone pulse and human immunoglobulin for intravenous injection (IVIG), resulting in complete recovery and discharge. Through literature review, it can be analyzed that MIS-C is systemic inflammatory response characterized by multi-organ dysfunction from a cytokine storm, which differentiates it from Kawasaki disease characterized by acute systemic vasculitis triggered by infectious factors, ultimately leading to cardiovascular accidents as the main cause of death.Conclusions When fever (≥38 ℃) persists for at least 24 hours, accompanied by high inflammatory symptoms and dysfunction in two or more systems, requiring intensive care treatment, and there is evidence of SARS-CoV-2 infection, MIS-C should be diagnosed early, and intervention and treatment should be initiated promptly to achieve favorable outcomes.

Objective:To explore effect of Shao Pai febrile diseases nursing in patients with chronic obstructive pulmonary disease (COPD) of lung and kidney deficiency type.Methods:From January 2019 to August 2020, convenience sampling was used to select 100 patients with COPD of lung and kidney deficiency type in the Respiratory Department, Shaoxing Hospital of Traditional Chinese Medicine as the research object. According to the random number table method, the patients were divided into the nursing group and the control group, 50 cases in each group. The control group was intervened by conventional nursing, while the nursing group conducted Shao Pai febrile diseases nursing on the basis of conventional nursing, and the intervention was continued for three months. The modified Medical Research Council (mMRC) and St George's Respiratory Questionnaire (SGRQ) were used to evaluate the influence of dyspnea on quality of life. The forced expiratory volume in one second (FEV1) , FEV1 as a percentage of predicted force vital capacity (FEV1%) , and peak expiratory flow (PEF) were compared between the two groups before and after treatment.Results:After treatment, the dyspnea in the nursing group was better than that in the control group, and the total score of SGRQ and the scores of each dimension were lower than those in the control group, and the FEV1, FEV1% and PEF were higher than those in the control group, and the above differences were statistically significant ( P<0.05) . Conclusions:The Shao Pai febrile diseases nursing can further improve the lung function of patients with COPD of lung and kidney deficiency type, reduce the degree of dyspnea, and improve the quality of life of the patients.