Problem-based learning (PBL) has been applied in many teaching fields and achieved satisfying effect. Dermatovenology is a special secondary discipline of clinical medicine which includes dermatosurgery, dermatopathology, laser cosmetology and other different sub-professional subjects, and it covers a wide variety of diseases and it is difficult to identify skin lesions. However, the teaching time for graduate students is limited and the traditional teaching mode can't meet the needs of learning for them. In this paper, the application of PBL method in the teaching of medical graduate students and the application of PBL combined with other teaching methods have been expounded through the analysis of domestic and foreign literature, and its role in the teaching of dermatology graduate students will be discussed.