Objective:To observe the clinical effect of omeprazole based triple therapy in the treatment of children with peptic ulcer.Methods:From September 2016 to September 2018, 86 children with peptic ulcer in the People's Hospital of Qingyuan County were selected in this study.By using the random number table method, they were divided into two groups, with 43 cases in each group.The control group received ranitidine based triple therapy treatment, the observation group was given omeprazole based triple therapy treatment.The treatment course of the two groups was 30 d. The eradication rate, clinical effect, gastrointestinal hormone level and adverse reactions of helicobacter pylori were compared between the two groups.Results:The eradication rate and total effective rate of helicobacter pylori in the observation group were 97.67%(42/43) and 95.35%(41/43), respectively, which were higher than those in the control group[81.40%(34/43) and 79.07%(34/43)], the differences were statistically significant (χ 2=6.081, 5.108, all P<0.05). After treatment, the levels of gastrin and motilin in the observation group were (75.29±8.31)μmol/L, (164.88±15.05)ng/L, respectively, which were lower than those in the control group [(81.07±8.96)μmol/L, (204.15±17.67)ng/L], the differences were statistically significant( t=3.102, 11.095, all P<0.05). The somatostatin level of the observation group was (22.67±3.95)ng/L, which was higher than that of the control group [(18.31±3.31)ng/L], and the difference was statistically significant( t=5.548, P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ 2=0.938, P>0.05). Conclusion:Omeprazole based triple therapy is safe and effective in the treatment of children with peptic ulcer, which is helpful to eradicate helicobacter pylori, reduce gastrin, motilin levels and improve the level of somatostatin.

Objective To investigate the effect of acceptance and commitment therapy intervention on post-traumatic growth of patients with concomitant brain injury in group context. Methods From January 2016 to January 2017, 40 patients with recovery from craniocerebral injury such as car accidents and work-related injuries were set as the control group, and regular health education and guidance were conducted twice a week for 6 times. From February to February 2018, 42 patients with recovery from craniocerebral injury such as car accidents and work-related injuries were set as observation groups. The observation group was given a 3-week group acceptance and commitment therapy intervention on the basis of the control group. Before and after the intervention, the simplified Chinese version of the post-traumatic growth rating scale was used for evaluation. Results After intervention, the total scores of life perception, personal strength, new possibility, relationship with others, self-transformation and post-traumatic growth were (18.68 ± 3.86), (11.35 ± 2.67), (10.49 ± 2.48), (14.35 ± 2.95), (10.49 ± 2.32), (65.36 ± 14.28) points in the observation group, and were (13.23±3.10), (9.46±2.41), (6.82±1.72), (11.81±2.06), (7.91 ± 1.89), (49.23 ± 11.18) points the control group, the difference between the two groups were statistically significant (t=7.325-8.289, both P<0.05). Conclusions Group acceptance and commitment therapy intervention can improve the post-traumatic growth level of patients with recovery period of craniocerebral injury, and provide a reliable basis for clinical medical staff to promote positive psychological adjustment of patients with recovery period of craniocerebral injury.