Eukaiyotic translation initiation factor 4E(eIF4E) is a key factor initiate eukaryotic transla-tion. eIF4E has significant correlation with the carcinogenesis, cancer development and invasion, etc. Recent studies in breast cancer show that eIF4E is an important prognostic factor and associated with sensitivity of breast cancer cells to radiotherapy. eIF4E expression has a potential contribution to therapeutic strategy mak-ing, meanwhile, it is a promising effective target of breast cancer treatment.

The non-coding miRNA is classified into different families according to their gene structure and function.It is involved in many cellular processes,such as proliferation,differentiation and apoptosis.Recently it has been proved that miRNA has played an important role in the pathogenesis of many cancers,acting as oncogenic miRNAs or tumor suppressor,including acute lymphoblastic leukemia (ALL).Because miRNA is highly connected with the pathogenesis,diagnosis,prognosis and drug-resistant of childhood ALL,it might be a new breakout for the diagnosis and treatment of ALL.This paper reviews current literatures on miRNA and childhood ALL.

HOXB gene is a homeobox gene family member and plays an important role in hematopoietic regulation.The abnormal expression is involved in leukemia.High expression of different subtypes influence leukemia progress and phenotype,and are closely related with leukemia treatment and prognosis.The higher the expression level is,the worse prognosis is.Many methods such as transgenic,inhibit of P21,combined with cytokine or MS-5 cell lines( all-trans retinoic acid) at the genetic level can reveal the pathogenesis of leukemi a and provide theoretical basis for treatment and prognosis.

Multiple myeloma (MM) is a malignancy of the plasma cells, characterized by complex karyotype and chromosome instability. These cytogenetic changes are important prognostic indicators in MM patients. Fluorescence in situ hybridization (FISH) can analyze a large number of interphase cells without metaphase. It is simple, reproducible, highly sensitive and specific. It has more prominent advantages in the research of MM without informative metaphase. FISH can detect microdeletions in genetic loci that are closely related to disease prognosis, therefore significantly improves the abnormal clone detection rate. FISH provides a theoretical foundation for the diagnosis, clinical classification and prognosis prediction, and can guide the personalized therapy of MM.

Mucosa-associated lymphoid tissue (MALT) lymphoma originates from outside of the lymph nodes, which is a kind of low-grade malignant lymphoma and the most type of marginal zone lymphoma (MZL).It accounts for about 30 ％-50 ％ of the indolent NHL.The onsets and therapies of MALT lymphoma are diverse.This article focuses on the recent therapeutic advances of MALT lymphoma.

[Objective]To summarize the growth of 51 famous experts in traditional Chinese medicine, in order to provide the young and middle-aged scholars of this area with studying materials and references. [Methods] Finding the similarities and making a summary by interviewing, organizing and ana-lyzing the growing experiences of these 51 experts. [Results]Being enthusiastic about traditional culture of Chinese medicine and having careful y read re-lated classics when studying medicine, most of the experts have either experiences of learning from famous doctors, or strong interest motivated by learning the practical effect of traditional Chinese medicine. They have been insisting on a lifetime, perseverant, diligent and strenuous learning, and they are good at summarizing. In addition, they have attached great importance to medical ethics and self-cultivation, which is considered to be the general characteristic of their bril iance. [Conclusions] To cultivate talents of modern Chinese medicine under the roof of col eges and institutes, it is important to develop their interest first, then to put great emphasis on reading classics, learning from famous doctors, summarizing through the way of “reading-clinical verification-reading again”, and final y, paying great attention to the education of medical ethics.

Neuropathic pain arises as a direct consequence of a lesion or disease affects the somatosensory.Its symptoms include spontaneous,hyperalgesia and allodynia pain.Pain management is not satisfied through merely analgesics.To manage pain effectively is difficult in clinic.The paper is to review the progress of the mechanism of neuropathic pain.

In order to compare the effect of megadoses of vitamin B6 and C on serum lipids and atheroscleosis, 25 New Zealand strain rabbits (male) fed high cholesterol diet every day were divided into four groups.Group A as control, received only cholesterol diet. 125mg.kg-1.d-1 of vitamin B6 was given to group B, 500mg.kg-1.d-1 of vitamin C to group C, and 125mg.kg-1.d-1 vitamin B6+500 mg.kg-1.d-1 vitamin C to group D, all by oral administration. Fasting serum was sampled at 2-week intervals during a 10-week experimental period. After 10 weeks, killed all the rab- bits, check their urethrae and determined the vitamin C content of the adrenal glands. The aorta was examined by measuring the size of plaques OR aorta wall and investigated pathologically.The results were (1) The body weight increased in every group gave no remarkable difference. (2) Serum total-cholesterol (TC) of group B was apparently lower than group A at 8th week (P

Objective To study the clinical efficacy of epirubicin combined with paclitaxel in the treatment of three negative breast cancer.Methods 100 patients with breast cancer who were treated in Shanxi Cancer Hospital from January 2014 to December 2016 were selected as the research object in this study.They were randomly divided into the control group and the experimental group, with each group having a total of 50 patients.The control group was treated with epirubicin, and the experimental group was treated with epirubicin combined with paclitaxel.The short-term remission rate, Karnofsky score and the incidence of adverse symptoms were compared between the experimental group and the control group.Results After treatment, the Karnofsky score of the experimental group was(89.76±10.12), and the Karnofsky score of the control group was(71.23±11.67).The Karnofsky score of the experimental group was significantly higher than that of the control group (P<0.05).In the experimental group, the number of short-term remission was 44 cases, the short-term remission rate was 88.0%, and the number of patients in the control group in the recent remission was in the number of cases, the short-term remission rate was 72.0%, and the number of patients in the control group was about 36.The results showed that the short-term remission rate of the experimental group was significantly higher than that of the control group, with statistical difference (P<0.05).After treatment, there was no significant difference between the control group and the experimental group in the incidence of complications, which was not statistically significant.Conclusion The clinical effect of doxorubicin plus paclitaxel in the treatment of three negative breast cancer, can improve the remission rate in a large extent, improve the quality of life of patients, with further clinical promotion and application significance.

Objective To study the clinical effect of minocycline hydrochlorideointment on the treatment of patients with retrograde pulpitis.Methods From January 2015 to December 2016 in Huzhou central hospital, 90 cases with retrograde pulpitis as the research object were divided into two groups, the control group and the observation group, 45 cases in each group.The control group were received conventional treatment combined with iodine glycerin, and the observation group were given conventional treatment combined with minocycline hydrochloride ointment.The clinical data were compared in the two groups.Results After treatment, plaque index(0.91±0.30), gingival bleeding index(2.11±1.32), explore clinical depth(4.58±1.19)and attachment loss(3.06±1.85)in the observation group were better than the plaque index(1.38±0.49), gingival bleeding index(3.07±1.83),explore clinical depth(4.87±1.49)and attachment loss(5.18±1.39)in the control group, the difference between the two groups was statistically significant(P< 0.05);the clinical effect 95.6% in the observation group was better than 80.0% in the control group(P< 0.05).The adverse reaction rate was 6.7% in the observation group, which was lower than 17.8% in the control group(P< 0.05).Conclusion It that the conventional method combined with minocycline hydrochloride ointment on the treatment of retrograde pulpitis has significant clinical effect, can effectively improve the clinical symptoms of patients, is worthy of clinical application.