Objective To investigate the relationships of the subsets and activation factors of pe-ripheral blood innate lymphocytes(ILCs)with postoperative intracranial infection in patients with hy-pertensive basal ganglia hemorrhage.Methods A total of 105 patients with postoperative intracranial infection(infection group)and 105 patients without infection(non-infection group)were selected as research subjects.The patients in the infection group were divided into mild infection group(n=33),moderate infection group(n=50)and severe infection group(n=22)according to the severity of postoperative intracranial infection.The patients in the infection group were divided into good prog-nosis group(n=53)and poor prognosis group(n=52)according to different outcomes.The subsets of ILCs(ILC1,ILC2,ILC3),interleukin(IL)-12,IL-33,IL-1 β levels in peripheral blood were compared among the groups.The correlation between each index and the severity of intracranial infec-tion and the predictive value of poor prognosis in infected patients were analyzed.Results Compared with the non-infection group,the levels of ILC2 and ILC3 in the infection group were reduced,while the levels of IL-12,IL-33 and IL-1β were increased(P＜0.05).The levels of ILC2 and ILC3 in infected patients decreased with the increase of infection severity,while the levels of IL-12,IL-33 and IL-1 β increased with the increase of infection severity(P＜0.05).The levels of ILC2 and ILC3 in patients with intracranial infection werenegatively correlated with the severity of infection(r=-0.721,-0.596,P＜0.001),while the levels of IL-12,IL-33 and IL-1 β were positively correlated with the severity of infection(r=0.576,0.483,0.553,P＜0.001).The combined pre-diction of peripheral blood ILC2,ILC3,IL-12,IL-33 and IL-1 β for poor prognosis in infected patients had a higher A UC(0.930)and specificity(84.91％)than each index alone.Conclusion The lev-els of peripheral blood ILC2,ILC3,IL-12,IL-33 and IL-1 β in patients with postoperative intracra-nial infection after hypertensive basal ganglia hemorrhage are associated with the severity of infec-tion.The combined detection of five indicators has a good predictive value for poor prognosis in in-fected patients.

Objective To investigate the relationships of the subsets and activation factors of pe-ripheral blood innate lymphocytes(ILCs)with postoperative intracranial infection in patients with hy-pertensive basal ganglia hemorrhage.Methods A total of 105 patients with postoperative intracranial infection(infection group)and 105 patients without infection(non-infection group)were selected as research subjects.The patients in the infection group were divided into mild infection group(n=33),moderate infection group(n=50)and severe infection group(n=22)according to the severity of postoperative intracranial infection.The patients in the infection group were divided into good prog-nosis group(n=53)and poor prognosis group(n=52)according to different outcomes.The subsets of ILCs(ILC1,ILC2,ILC3),interleukin(IL)-12,IL-33,IL-1 β levels in peripheral blood were compared among the groups.The correlation between each index and the severity of intracranial infec-tion and the predictive value of poor prognosis in infected patients were analyzed.Results Compared with the non-infection group,the levels of ILC2 and ILC3 in the infection group were reduced,while the levels of IL-12,IL-33 and IL-1β were increased(P＜0.05).The levels of ILC2 and ILC3 in infected patients decreased with the increase of infection severity,while the levels of IL-12,IL-33 and IL-1 β increased with the increase of infection severity(P＜0.05).The levels of ILC2 and ILC3 in patients with intracranial infection werenegatively correlated with the severity of infection(r=-0.721,-0.596,P＜0.001),while the levels of IL-12,IL-33 and IL-1 β were positively correlated with the severity of infection(r=0.576,0.483,0.553,P＜0.001).The combined pre-diction of peripheral blood ILC2,ILC3,IL-12,IL-33 and IL-1 β for poor prognosis in infected patients had a higher A UC(0.930)and specificity(84.91％)than each index alone.Conclusion The lev-els of peripheral blood ILC2,ILC3,IL-12,IL-33 and IL-1 β in patients with postoperative intracra-nial infection after hypertensive basal ganglia hemorrhage are associated with the severity of infec-tion.The combined detection of five indicators has a good predictive value for poor prognosis in in-fected patients.