Pancreatic cancer (PC) is one of the deadliest solid malignancies.Although surgery remains the only curative treatment,more than 80％ of patients suffer relapse after resection.More and more data evidence that PC is a systemic disease suggests systemic therapy plays crucial roles in the multidisciplinary treatment.Thus,new treatments are urgently needed for PC patients.Recently,a growing number of novel and promising drugs are being evaluated in preclinical and clinical settings.Herein,we reviewed the progress in the new cytotoxic and targeted therapy for metastatic PC.

Objective To investigate the efficacy and safety of uterine brace suture technique in the treatment of postpartum hemorrhage caused by uterine inertia.Methods 63 cases of postpartum hemorrhage of cesarean section were divided into two groups.33 patients treated with uterine brace suture technique severd as the research group.30 patients treated with traditional technique for postpartum hemorrhage of cesarean section were recruited as the control group.Operation time,hemorrhage volume,puerperal morbidity and therapeutic efficacy between the two groups were compared.Results Operation time was(53.31 4±10.61)min in the research group,and(76.16±13.73)rain in the control group,respectively.There were(601.00±162.36)ml of hemorrhage volume in the research group,and(1 063.33±320.10)ml in the control group,respectively.No case with hysterectomy in the research group,however 5 cases were treated with hysterectomy in the control group.There were 2 cases of puerperal morbidity in the research group,and 9 cases in the control group,respectively.The differences were statistically significant in operation time,hemorrhage volume,puerperal morbidity and therapeutic efficacy between the research group and the control group(t=7.428,7.121,χ2=4.698,all P＜0.05).Conclusion Uterine brace suture technique is one of effective treatment for postmnurn hemorrhage caused by uterine inertia,particularly useful because of its simplicity of application and relative safety.It Was worthy to be popularized in primary hospitals.

AIM: The effective antisense sequences targeted VEGF mRNA with computer software would be screened and designed, and effect of them on growth K562 cells and protein expression of VEGF were studied with experiments. METHODS: Seven antisense sequences were selected and synthesized, which consisted of 18-20 deoxynucleotide acid and were modified with phosphorothioate, according to principle of low free energy of overall △G 37 Overall. Cell growth was assayed by trypan blue dye exclusion assay and level of VEGF protien in the media was determined by ELISA. RESULTS: Six of seven sequences were capable of inhibing growth of K562 cells and downregulating the VEGF protein expression significantly, compared with Scrambed control group. It was found that there was a close correlation between low level of overall △G 37 and antisense effectiveness ( r =0 887, P

OBJECTIVE:To evaluate the present situation and trend of the antidepressants.METHODS:The antidepres?sants drugs in21hospitals of Hangzhou during2000～2003was statistically analyzed with respect to sales sum,market struc?ture etc.RESULTS:The total amount for antidepressants increased dramatically year by year.The consumption of the im?ported antidepressants has been decreasing while that of the domestic has been increasing and that of the antidepressants from the joint ventures remained stable.CONCLUSION:There is a great potential for the development of antidepressants;the sales amount and the consumption sum take on a trend of increasing rapidly.

Objective To study the effect of Shenqiwan and vitamin E on mtDNA 4834 deletion in a mimetic aging rat model .Methods Forty rats three months old ,were randomly divided into four groups :group A ,which was treated with hypodermic 5 % D -galactose for 8 weeks ,and group B (shenqiwan group ,n=10) which was treated daily with Shenqiwan for 2 weeks after hypodermic 5 % D -galactose for 6 weeks ,group C (vitamin E group ,n = 10) which were treated daily with Vitamin E for 2 weeks after hypodermic 5 % D -galactose for 6 weeks ,group D were given saline only .Auditory brainstem response (ABR) was used to detect the hearing thresh-old of rats before and after the treatment .The inner ear tissue was harvested and mitochondrial DNA was amplified to identify the 4834 bp deletion mutation by nested primer polymerase chain reaction (nested PCR) technique .Re-sults The threshold of ABR in the group A ,B and C were significant higher than that in group D .However the difference in shift of ABR threshold between group A ,B ,C and group D was not significant .The mtDNA4834 de-letion rate in three modeled groups (group A ,B ,C) was significant high than that of in group D .There was statis-tically significant difference between the treated group (group B ,C) and the model group (group A) on mtDNA4834 deletion in cochlea ,but the difference between the treated groups on mtDNA 4834 deletion in cochlea was not statistically significant .Conclusion Shenqiwan and vitamin E can reduce the aging induced mtDNA 4834 deletion in aging rats inner ear .

Objective To explore clinical features and misdiagnosis reasons in mitochondrial encephalomyopathy,lactic acidosis,and stroke-like episodes (MELAS) syndrome.Methods The results of clinical data,brain magnetic resonance imaging (MRI),and the course of diagnosis were analyzed in 6 patients with MELAS.Results (1) Clinical features:headache and vomiting were the starting symptoms in 4 of 6 cases,and developmental delay was initial symptoms in 2 of 6 cases.Marasmus occurred in 6 cases,seizure in 5 cases,fever in 3 cases,and hirsutism and visual impairment in 2 cases.(2) Experimental results:blood lactic acid was higher in 6 (4.28 ～ 10.3 mmol/L).(3) Brain MRI:6 patients had abnormal signals in parietal,occipital,temporal lobe,which were not in accordance with vascular distribution.(4) Molecular genetics:All the 6 patients had A3243G gene mutation.(5) Three patients were misdiagnosed for viral encephalitis,and 2 developmental retardation.Conclusions MELAS is characterized with developmental retardation,and repeated encephalitis attack.It is also misdiagnosed because of its variety of clinical features.If patients have high level of lactic acid and multiple MRI signal abnormalities of brain which are not in accordance with vascular distribution,MELAS should be suspected of.Genetic examination and muscle biopsy are especially important in the diagnosis of MELAS.

Through the literature combing the interest groups of hospital information disclosure in the United States, the demand and practice of the main interest groups are analyzed. This paper uses policy maker4. 0 software to further analyze the interests of various interest groups, power and the degree of influence by the policy of hospital information disclosure. The results showed that interest groups involved in hospital information disclosure in the Unit-ed States can be mainly divided into five categories:consumers, employers, health insurance companies, hospitals, and decision makers ( government) . In order to balance the cost-effectiveness of various insurance schemes, health insurance companies choose high-quality service providers to restrict poor-service providers and insurers, and hospi-tals need to use public information to manage and improve health care. In order to monitor and improve the quality of medical services, employers need to weigh various insurance plans, health insurance companies have to measure the service quality of themselves and competitors, and hospitals need to manage and improve the medical quality and in-crease market share. As the largest stake in the hospital information disclosure, the results show that the consumer's position on the hospital information disclosure is low support. From the consumer as a main, although the hospital in-formation disclosure practices but the right to speak and other small powers have a limited participation. Analyzing the of the interest groups of hospital information disclosure in the United States, they all push forward the hospital infor-mation disclosure work to provide evidence to support.

Objective:To summarize the participation of clinical pharmacists in the treatment of patients after craniocerebral opera-tion with pulmonary infection. Methods: Clinical pharmacists assisted physicians in identifying infectious bacteria and colonization bacteria of one patient with pulmonary infection after craniocerebral operation and establishing the anti-infection treatment regimen. Re-sults:Clinical pharmacists analyzed various factors such as infection risk factors, clinical and laboratory manifestation and medication history, and effectively selected antibacterial drugs covering the infectious bacteria to timely control the infection. Conclusion: With pharmaceutical knowledge, clinical pharmacists can assist physicians in the interpretation of bacterial culture and drug susceptibility re-ports to promote safer, more timely and effective medication for patients.

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Bone marrow cell morphology is a difficult point in laboratory diagnostics teaching.Computer-aided instruction(CAI) teaching documents were made according to the teaching outlines of laboratory diagnostics.The CAI teaching documents,which represent distinct cellular features of different types of bone marrow cells,were applied in normal and hematological diseases of bone marrow cell morphology teaching,combined with proper teaching methods.It proved to be a useful teaching style in improving teaching and learning efficiency in laboratory diagnostics.