The author had carried out the analysis on the sports value of competitive sports for the disabled from the bioethical view , based on the following points:the individual value in the disabled competitive sports;core val-ue of competitive sports for the disabled ethics;the meaning of life and the value of competitive sports for the disa-bled;humanistic rational values of the instrumental rationality;competitive sports for the disabled and links to the real life, and so forth.

In the view of the ethics, this paper analyzed the present situation and problems of special physical education practitioners in China, and pointed out that the conflict of values, conflict of interests, job burnout, and educational value view were the practical ethical confusion that influenced special physical education practitioners. It put forward that ethical construction of special physical education practitioners should set up human-oriented concept, highlight the ethical feelings of humanism, formulate feasible and operable ethical norms for special physi-cal education work, improve practitioners′professional proficiency and ethical awareness, and establish the human-oriented humanistic care professional ethics idea.

In recent years,the clinical utility of circulating tumor cells (CTCs)analysis from peripheral blood has undoubtedly become a popular topic in the field of precision medicine.CTCs analysis is a noninvasive,easily obtained and highly repeatable testing approach,and could be carried out in a real-time manner,which has never failed to surprise us with great progression in the detection of early disease,assessing prognosis,treatment response monitoring and individualized therapeutic direction in breast cancer.

Objective To analyse the clinical and pathological characteristics of patients with myopathies that were misdiag-nosed as myasthenia gravis because of external ophthalmoplegia ,widen the thoughts for differential diagnosis of extraocular muscle paralysis .Methods The clinical and pathological features of 11 myopathy cases with ptosis and diplopia admitted to the neurology department of the First Affiliated Hospital of Chongqing Medical University between October 2010 and May 2014 were retrospec-tively reviewed and analyzed .Results Among the 11 patients ,6 male and 5 female ,aged 16-66 years old .All had paralysis of ex-traocular muscle manifestations ,including oculopharyngeal muscular dystrophy(OPMD) in 3 cases ,oculopharyngeal distal myopa-thy in 2 cases ,chronic progressive external ophthalmoplegia(CPEO) in 6 cases .Muscle biopsy showed the characteristic pathologi-cal changes .Statistical analysis showed that the age of onset in OPMD patients was older(P<0 .05) ,creatine kinase level in oculo-pharyngeal distal myopathy patients was higher ,but the difference was not significant (P>0 .05) .Conclusion Certain rare myopa-thy should be considered for patients with external ophthalmoplegia seemingly myasthenia gravis .Muscle biopsy can provide clue for differential diagnosis .

This paper introduces the principle and parameters of the ophthalmic excimer laser curer. Such aspects are also involved in as the detection method and device for the parameters of the excimer laser as well as the selection of the detection devices.

Objective To establish a HPLC method for the determination of emodin in Niuhuang anti-inflammatory tablets. Method Thermo-Hypersil C18 (250 mm?4.6 mm, 5 ?m) was used, mobile phase was methanol-0.1% phosphoric acid (70∶30), with flow rate of 1.0 mL/min, detection wavelength of 254 nm, and column temperature was 40 ℃. Results There was a good linear relationship of emodin at the range of 0.020 11～0.402 2 ?g. Conclusion The method is simple, accurate, with better separation efficiency, wide linear range and high sensitivity. It can be used for quality control of the preparation.

Objective: To observe the protective effect of oxymatrine (OMT) against chronic cardiotoxicity induced by adriamycin (ADR). Methods: Twenty six rabbits were randomly devided into four groups. The ADR group (n = 8) were injected with ADR (2 mg/kg) via auricular vein once a week for 8 weeks to induce chronic heart injury. The ADR + OMT group (n = 8) received intraveneous injection of OMT 10 mg/kg at 30 min before administration of ADR. The normal saline group (n = 5) received the same volume of 0.9% saline alone and the OMT group (n =5) received intraveneous injection of OMT alone. Before administration and 3 weeks after drug therapy, a catheter was advanced through left carotid artery and left ventricle to measure heart rate(HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), and left ventricular injection fraction (LVEF). The serum was collected for determination of the activities of lactate dehydrogenase (LDH) and creatine kinase isoenzyme MB (CK-MB). The myocardial ultrastructure changes were observed by electron microscropy at 3 weeks after drug therapy. Results: Compared with ADR + OMT group, both LVSP and LVEF in ADR group were signi-ficantly decreased, but LVEDP and the activities of LDH and CK-MB were significantly increased. The difference between the two groups was significant. Pathological examination demonstrated the more severer damage of the myocardial ultrastructure in ADR group than ADR + OMT group. No adverse reaction and pathological changes were observed in OMT group. Conclusion: Oxymatrine protects heart against adriamycin-induced injury in rabbits.

Breast cancer screening is an economical, effective, and simple screening measure for asymptomatic people to achieve the goals of early detection, early diagnosis and early treatment. Existing screening methods are mainly based on breast cancer X-rays and ultrasound, which are less sensitive to early lesions and cannot assess the risk of breast cancer in asymptomatic people. Breast cancer susceptibility genes, DNA methylation, microRNAs and circulating tumor cells, as blood biomarkers for breast cancer screening and early diagnosis, can identify high-risk breast cancer populations and improve the early diagnosis rate of breast cancer.

Rotator cuff tears are common shoulder injuries.Because of the advantages of less injury and quick rehabilitation,arthroscopic rotator cuff repair becomes one of the major methods to treat the rotator cuff tears.Postoperative rehabilitation is also as important as the operation of rotator cuff repair.

Objective:To investigate the relationship between N-myc downstream-regulated gene-1 (NDRG-1) gene expression and the progression and metastasis of uterine cervical squamous cell carcinoma (UCSCC). Methods: NDRG-1 protein expression was detected by immunohistochemistry (IHC) in 42 cases of UCSCC, 30 cases of high-grade squamous intraepithelial lesion (HSIL), 28 cases of low-grade squamous intraepithelial lesion (LSIL), and 20 cases of normal squamous epithelium. NDRG-1 mRNA was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in 10 cases of UCSCC and 10 cases of normal squamous epithelium. Results: The expressions of NDRG-1 mRNA and protein in UCSCC were significantly lower than normal squamous epithelium tissues (P < 0.01). From normal squamous epithelium to LSIL, HSIL and UCSCC, NDRG1 protein was gradually decreased during tumor carcinogenesis. The difference was significant (P < 0.01). NDRG-1 mRNA and protein in metastatic UCSCC were obviously lower than non metastatic UCSCC (P < 0.05). Conclusion: Down-regulation of NDRG1 mRNA and protein in UCSCC indicate that NDRG1 gene might correlate with carcinogenesis, progression, and metastasis of cervical squamous carcinoma.