Sarcoidosis is a multisystemic granulomatous disease with an of unknown etiology, involving bilateral hilar lymphadenopathy, pulmonary, skin and eye lesions. However, involvement of the endocrine system in sarcoidosis is quite rare, and the coexistence of both diseases is extremely unusual. We describe a 60-year-old woman presenting with sarcoidosis and Graves' disease. She was admitted for evaluation of dry cough, dyspnea, palpitation and general weakness. Both thyroid glands were enlarged diffusely. The thyroid function tests showed suppressed serum thyrotropin and an increased thyroid hormone level. The levels of the TSH receptor antibody, anti-thyroglobulin antibody and anti-microsomal antibody were higher than normal. The radionuclide scan(131I) showed increased iodine uptake. The chest X-ray revealed pulmonary hilar enlargement and high resolution CT showed both hilar lymph nodes enlargement and tiny parenchymal nodules. The transbronchial lung biopsy showed a noncaseating granuloma without necrosis. We report this case of pulmonary sarcoidosis plus Graves' disease with a review of the relevant literatures.
Biopsy ; Cough ; Dyspnea ; Endocrine System ; Female ; Granuloma ; Graves Disease* ; Humans ; Hyperthyroidism ; Iodine ; Lung ; Lymph Nodes ; Lymphatic Diseases ; Middle Aged ; Necrosis ; Receptors, Thyrotropin ; Sarcoidosis ; Sarcoidosis, Pulmonary* ; Skin ; Thorax ; Thyroid Function Tests ; Thyroid Gland ; Thyrotropin