1.Emotion Recognition in Multiple System Atrophy: An Exploratory Eye-Tracking Study
Victoria SIDOROFF ; Federico CARBONE ; Philipp ELLMERER ; Stefanie BAIR ; Alexandra HOFFMANN ; Thomas MARAN ; Florian KRISMER ; Philipp MAHLKNECHT ; Katherina MAIR ; Cecilia RACCAGNI ; Jean-Pierre NDAYISABA ; Klaus SEPPI ; Gregor K. WENNING ; Atbin DJAMSHIDIAN
Journal of Movement Disorders 2024;17(1):38-46
Objective:
Emotional processing is a core feature of social interactions and has been well studied in patients with idiopathic Parkinson’s disease (PD), albeit with contradictory results. However, these studies excluded patients with atypical parkinsonism, such as multiple system atrophy (MSA). The objective of this exploratory study was to provide better insights into emotion processing in patients with MSA using eye tracking data.
Methods:
We included 21 MSA patients, 15 PD patients and 19 matched controls in this study. Participants performed a dynamic and a static emotion recognition task, and gaze fixations were analyzed in different areas of interest. Participants underwent neuropsychological testing and assessment of depression and alexithymia.
Results:
MSA patients were less accurate in recognizing anger than controls (p = 0.02) and had overall fewer fixations than controls (p = 0.001). In the static task, MSA patients had fewer fixations (p < 0.001) and a longer time to first fixation (p = 0.026) on the eye region. Furthermore, MSA patients had a longer fixation duration overall than PD patients (p = 0.004) and longer fixations on the nose than controls (p = 0.005). Alexithymia scores were higher in MSA patients compared to controls (p = 0.038).
Conclusion
This study demonstrated impaired recognition of anger in MSA patients compared to HCs. Fewer and later fixations on the eyes along with a center bias suggest avoidance of eye contact, which may be a characteristic gaze behavior in MSA patients.
2.The Italian Unitary Society of Colon-Proctology (Società Italiana Unitaria di Colonproctologia) guidelines for the management of acute and chronic hemorrhoidal disease
Antonio BRILLANTINO ; Adolfo RENZI ; Pasquale TALENTO ; Luigi BRUSCIANO ; Luigi MARANO ; Maurizio GRILLO ; Mauro Natale MAGLIO ; Fabrizio FORONI ; Alessio PALUMBO ; Maria Laura Sandoval SOTELO ; Luciano VICENZO ; Michele LANZA ; Giovanna FREZZA ; Massimo ANTROPOLI ; Claudio GAMBARDELLA ; Luigi MONACO ; Ilaria FERRANTE ; Domenico IZZO ; Alfredo GIORDANO ; Michele PINTO ; Corrado FANTINI ; Marcello GASPARRINI ; Michele Schiano DI VISCONTE ; Francesca MILAZZO ; Giovanni FERRERI ; Andrea BRAINI ; Umberto COCOZZA ; Massimo PEZZATINI ; Valeria GIANFREDA ; Alberto DI LEO ; Vincenzo LANDOLFI ; Umberto FAVETTA ; Sergio AGRADI ; Giovanni MARINO ; Massimiliano VARRIALE ; Massimo MONGARDINI ; Claudio Eduardo Fernando Antonio PAGANO ; Riccardo Brachet CONTUL ; Nando GALLESE ; Giampiero UCCHINO ; Michele D’AMBRA ; Roberto RIZZATO ; Giacomo SARZO ; Bruno MASCI ; Francesca DA POZZO ; Simona ASCANELLI ; Patrizia LIGUORI ; Angela PEZZOLLA ; Francesca IACOBELLIS ; Erika BORIANI ; Eugenio CUDAZZO ; Francesca BABIC ; Carmelo GEREMIA ; Alessandro BUSSOTTI ; Mario CICCONI ; Antonia Di SARNO ; Federico Maria MONGARDINI ; Antonio BRESCIA ; Leonardo LENISA ; Massimiliano MISTRANGELO ; Matteo ZUIN ; Marta MOZZON ; Alessandro Paolo CHIRIATTI ; Vincenzo BOTTINO ; Antonio FERRONETTI ; Corrado RISPOLI ; Ludovico CARBONE ; Giuseppe CALABRÒ ; Antonino TIRRÒ ; Domenico DE VITO ; Giovanna IOIA ; Giovanni Luca LAMANNA ; Lorenzo ASCIORE ; Ettore GRECO ; Pierluigi BIANCHI ; Giuseppe D’ORIANO ; Alessandro STAZI ; Nicola ANTONACCI ; Raffaella Marina Di RENZO ; Gianmario Edoardo POTO ; Giuseppe Paolo FERULANO ; Antonio LONGO ; Ludovico DOCIMO
Annals of Coloproctology 2024;40(4):287-320
The aim of these evidence-based guidelines is to present a consensus position from members of the Italian Unitary Society of Colon-Proctology (Società Italiana Unitaria di Colon-Proctologia, SIUCP) on the diagnosis and management of hemorrhoidal disease, with the goal of guiding physicians in the choice of the best treatment option. A panel of experts was charged by the Board of the SIUCP to develop key questions on the main topics related to the management of hemorrhoidal disease and to perform an accurate and comprehensive literature search on each topic, in order to provide evidence-based answers to the questions and to summarize them in statements. All the clinical questions were discussed by the expert panel in multiple rounds through the Delphi approach and, for each statement, a consensus among the experts was reached. The questions were created according to PICO (patients, intervention, comparison, and outcomes) criteria, and the statements were developed adopting the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) methodology. In cases of grade 1 hemorrhoidal prolapse, outpatient procedures including hemorrhoidal laser procedure and sclerotherapy may be considered the preferred surgical options. For grade 2 prolapse, nonexcisional procedures including outpatient treatments, hemorrhoidal artery ligation and mucopexy, laser hemorrhoidoplasty, the Rafaelo procedure, and stapled hemorrhoidopexy may represent the first-line treatment options, whereas excisional surgery may be considered in selected cases. In cases of grades 3 and 4, stapled hemorrhoidopexy and hemorrhoidectomy may represent the most effective procedures, even if, in the expert panel opinion, stapled hemorrhoidopexy represents the gold-standard treatment for grade 3 hemorrhoidal prolapse.
3.The Italian Unitary Society of Colon-Proctology (Società Italiana Unitaria di Colonproctologia) guidelines for the management of acute and chronic hemorrhoidal disease
Antonio BRILLANTINO ; Adolfo RENZI ; Pasquale TALENTO ; Luigi BRUSCIANO ; Luigi MARANO ; Maurizio GRILLO ; Mauro Natale MAGLIO ; Fabrizio FORONI ; Alessio PALUMBO ; Maria Laura Sandoval SOTELO ; Luciano VICENZO ; Michele LANZA ; Giovanna FREZZA ; Massimo ANTROPOLI ; Claudio GAMBARDELLA ; Luigi MONACO ; Ilaria FERRANTE ; Domenico IZZO ; Alfredo GIORDANO ; Michele PINTO ; Corrado FANTINI ; Marcello GASPARRINI ; Michele Schiano DI VISCONTE ; Francesca MILAZZO ; Giovanni FERRERI ; Andrea BRAINI ; Umberto COCOZZA ; Massimo PEZZATINI ; Valeria GIANFREDA ; Alberto DI LEO ; Vincenzo LANDOLFI ; Umberto FAVETTA ; Sergio AGRADI ; Giovanni MARINO ; Massimiliano VARRIALE ; Massimo MONGARDINI ; Claudio Eduardo Fernando Antonio PAGANO ; Riccardo Brachet CONTUL ; Nando GALLESE ; Giampiero UCCHINO ; Michele D’AMBRA ; Roberto RIZZATO ; Giacomo SARZO ; Bruno MASCI ; Francesca DA POZZO ; Simona ASCANELLI ; Patrizia LIGUORI ; Angela PEZZOLLA ; Francesca IACOBELLIS ; Erika BORIANI ; Eugenio CUDAZZO ; Francesca BABIC ; Carmelo GEREMIA ; Alessandro BUSSOTTI ; Mario CICCONI ; Antonia Di SARNO ; Federico Maria MONGARDINI ; Antonio BRESCIA ; Leonardo LENISA ; Massimiliano MISTRANGELO ; Matteo ZUIN ; Marta MOZZON ; Alessandro Paolo CHIRIATTI ; Vincenzo BOTTINO ; Antonio FERRONETTI ; Corrado RISPOLI ; Ludovico CARBONE ; Giuseppe CALABRÒ ; Antonino TIRRÒ ; Domenico DE VITO ; Giovanna IOIA ; Giovanni Luca LAMANNA ; Lorenzo ASCIORE ; Ettore GRECO ; Pierluigi BIANCHI ; Giuseppe D’ORIANO ; Alessandro STAZI ; Nicola ANTONACCI ; Raffaella Marina Di RENZO ; Gianmario Edoardo POTO ; Giuseppe Paolo FERULANO ; Antonio LONGO ; Ludovico DOCIMO
Annals of Coloproctology 2024;40(4):287-320
The aim of these evidence-based guidelines is to present a consensus position from members of the Italian Unitary Society of Colon-Proctology (Società Italiana Unitaria di Colon-Proctologia, SIUCP) on the diagnosis and management of hemorrhoidal disease, with the goal of guiding physicians in the choice of the best treatment option. A panel of experts was charged by the Board of the SIUCP to develop key questions on the main topics related to the management of hemorrhoidal disease and to perform an accurate and comprehensive literature search on each topic, in order to provide evidence-based answers to the questions and to summarize them in statements. All the clinical questions were discussed by the expert panel in multiple rounds through the Delphi approach and, for each statement, a consensus among the experts was reached. The questions were created according to PICO (patients, intervention, comparison, and outcomes) criteria, and the statements were developed adopting the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) methodology. In cases of grade 1 hemorrhoidal prolapse, outpatient procedures including hemorrhoidal laser procedure and sclerotherapy may be considered the preferred surgical options. For grade 2 prolapse, nonexcisional procedures including outpatient treatments, hemorrhoidal artery ligation and mucopexy, laser hemorrhoidoplasty, the Rafaelo procedure, and stapled hemorrhoidopexy may represent the first-line treatment options, whereas excisional surgery may be considered in selected cases. In cases of grades 3 and 4, stapled hemorrhoidopexy and hemorrhoidectomy may represent the most effective procedures, even if, in the expert panel opinion, stapled hemorrhoidopexy represents the gold-standard treatment for grade 3 hemorrhoidal prolapse.
4.The Italian Unitary Society of Colon-Proctology (Società Italiana Unitaria di Colonproctologia) guidelines for the management of acute and chronic hemorrhoidal disease
Antonio BRILLANTINO ; Adolfo RENZI ; Pasquale TALENTO ; Luigi BRUSCIANO ; Luigi MARANO ; Maurizio GRILLO ; Mauro Natale MAGLIO ; Fabrizio FORONI ; Alessio PALUMBO ; Maria Laura Sandoval SOTELO ; Luciano VICENZO ; Michele LANZA ; Giovanna FREZZA ; Massimo ANTROPOLI ; Claudio GAMBARDELLA ; Luigi MONACO ; Ilaria FERRANTE ; Domenico IZZO ; Alfredo GIORDANO ; Michele PINTO ; Corrado FANTINI ; Marcello GASPARRINI ; Michele Schiano DI VISCONTE ; Francesca MILAZZO ; Giovanni FERRERI ; Andrea BRAINI ; Umberto COCOZZA ; Massimo PEZZATINI ; Valeria GIANFREDA ; Alberto DI LEO ; Vincenzo LANDOLFI ; Umberto FAVETTA ; Sergio AGRADI ; Giovanni MARINO ; Massimiliano VARRIALE ; Massimo MONGARDINI ; Claudio Eduardo Fernando Antonio PAGANO ; Riccardo Brachet CONTUL ; Nando GALLESE ; Giampiero UCCHINO ; Michele D’AMBRA ; Roberto RIZZATO ; Giacomo SARZO ; Bruno MASCI ; Francesca DA POZZO ; Simona ASCANELLI ; Patrizia LIGUORI ; Angela PEZZOLLA ; Francesca IACOBELLIS ; Erika BORIANI ; Eugenio CUDAZZO ; Francesca BABIC ; Carmelo GEREMIA ; Alessandro BUSSOTTI ; Mario CICCONI ; Antonia Di SARNO ; Federico Maria MONGARDINI ; Antonio BRESCIA ; Leonardo LENISA ; Massimiliano MISTRANGELO ; Matteo ZUIN ; Marta MOZZON ; Alessandro Paolo CHIRIATTI ; Vincenzo BOTTINO ; Antonio FERRONETTI ; Corrado RISPOLI ; Ludovico CARBONE ; Giuseppe CALABRÒ ; Antonino TIRRÒ ; Domenico DE VITO ; Giovanna IOIA ; Giovanni Luca LAMANNA ; Lorenzo ASCIORE ; Ettore GRECO ; Pierluigi BIANCHI ; Giuseppe D’ORIANO ; Alessandro STAZI ; Nicola ANTONACCI ; Raffaella Marina Di RENZO ; Gianmario Edoardo POTO ; Giuseppe Paolo FERULANO ; Antonio LONGO ; Ludovico DOCIMO
Annals of Coloproctology 2024;40(4):287-320
The aim of these evidence-based guidelines is to present a consensus position from members of the Italian Unitary Society of Colon-Proctology (Società Italiana Unitaria di Colon-Proctologia, SIUCP) on the diagnosis and management of hemorrhoidal disease, with the goal of guiding physicians in the choice of the best treatment option. A panel of experts was charged by the Board of the SIUCP to develop key questions on the main topics related to the management of hemorrhoidal disease and to perform an accurate and comprehensive literature search on each topic, in order to provide evidence-based answers to the questions and to summarize them in statements. All the clinical questions were discussed by the expert panel in multiple rounds through the Delphi approach and, for each statement, a consensus among the experts was reached. The questions were created according to PICO (patients, intervention, comparison, and outcomes) criteria, and the statements were developed adopting the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) methodology. In cases of grade 1 hemorrhoidal prolapse, outpatient procedures including hemorrhoidal laser procedure and sclerotherapy may be considered the preferred surgical options. For grade 2 prolapse, nonexcisional procedures including outpatient treatments, hemorrhoidal artery ligation and mucopexy, laser hemorrhoidoplasty, the Rafaelo procedure, and stapled hemorrhoidopexy may represent the first-line treatment options, whereas excisional surgery may be considered in selected cases. In cases of grades 3 and 4, stapled hemorrhoidopexy and hemorrhoidectomy may represent the most effective procedures, even if, in the expert panel opinion, stapled hemorrhoidopexy represents the gold-standard treatment for grade 3 hemorrhoidal prolapse.
5.The Italian Unitary Society of Colon-Proctology (Società Italiana Unitaria di Colonproctologia) guidelines for the management of acute and chronic hemorrhoidal disease
Antonio BRILLANTINO ; Adolfo RENZI ; Pasquale TALENTO ; Luigi BRUSCIANO ; Luigi MARANO ; Maurizio GRILLO ; Mauro Natale MAGLIO ; Fabrizio FORONI ; Alessio PALUMBO ; Maria Laura Sandoval SOTELO ; Luciano VICENZO ; Michele LANZA ; Giovanna FREZZA ; Massimo ANTROPOLI ; Claudio GAMBARDELLA ; Luigi MONACO ; Ilaria FERRANTE ; Domenico IZZO ; Alfredo GIORDANO ; Michele PINTO ; Corrado FANTINI ; Marcello GASPARRINI ; Michele Schiano DI VISCONTE ; Francesca MILAZZO ; Giovanni FERRERI ; Andrea BRAINI ; Umberto COCOZZA ; Massimo PEZZATINI ; Valeria GIANFREDA ; Alberto DI LEO ; Vincenzo LANDOLFI ; Umberto FAVETTA ; Sergio AGRADI ; Giovanni MARINO ; Massimiliano VARRIALE ; Massimo MONGARDINI ; Claudio Eduardo Fernando Antonio PAGANO ; Riccardo Brachet CONTUL ; Nando GALLESE ; Giampiero UCCHINO ; Michele D’AMBRA ; Roberto RIZZATO ; Giacomo SARZO ; Bruno MASCI ; Francesca DA POZZO ; Simona ASCANELLI ; Patrizia LIGUORI ; Angela PEZZOLLA ; Francesca IACOBELLIS ; Erika BORIANI ; Eugenio CUDAZZO ; Francesca BABIC ; Carmelo GEREMIA ; Alessandro BUSSOTTI ; Mario CICCONI ; Antonia Di SARNO ; Federico Maria MONGARDINI ; Antonio BRESCIA ; Leonardo LENISA ; Massimiliano MISTRANGELO ; Matteo ZUIN ; Marta MOZZON ; Alessandro Paolo CHIRIATTI ; Vincenzo BOTTINO ; Antonio FERRONETTI ; Corrado RISPOLI ; Ludovico CARBONE ; Giuseppe CALABRÒ ; Antonino TIRRÒ ; Domenico DE VITO ; Giovanna IOIA ; Giovanni Luca LAMANNA ; Lorenzo ASCIORE ; Ettore GRECO ; Pierluigi BIANCHI ; Giuseppe D’ORIANO ; Alessandro STAZI ; Nicola ANTONACCI ; Raffaella Marina Di RENZO ; Gianmario Edoardo POTO ; Giuseppe Paolo FERULANO ; Antonio LONGO ; Ludovico DOCIMO
Annals of Coloproctology 2024;40(4):287-320
The aim of these evidence-based guidelines is to present a consensus position from members of the Italian Unitary Society of Colon-Proctology (Società Italiana Unitaria di Colon-Proctologia, SIUCP) on the diagnosis and management of hemorrhoidal disease, with the goal of guiding physicians in the choice of the best treatment option. A panel of experts was charged by the Board of the SIUCP to develop key questions on the main topics related to the management of hemorrhoidal disease and to perform an accurate and comprehensive literature search on each topic, in order to provide evidence-based answers to the questions and to summarize them in statements. All the clinical questions were discussed by the expert panel in multiple rounds through the Delphi approach and, for each statement, a consensus among the experts was reached. The questions were created according to PICO (patients, intervention, comparison, and outcomes) criteria, and the statements were developed adopting the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) methodology. In cases of grade 1 hemorrhoidal prolapse, outpatient procedures including hemorrhoidal laser procedure and sclerotherapy may be considered the preferred surgical options. For grade 2 prolapse, nonexcisional procedures including outpatient treatments, hemorrhoidal artery ligation and mucopexy, laser hemorrhoidoplasty, the Rafaelo procedure, and stapled hemorrhoidopexy may represent the first-line treatment options, whereas excisional surgery may be considered in selected cases. In cases of grades 3 and 4, stapled hemorrhoidopexy and hemorrhoidectomy may represent the most effective procedures, even if, in the expert panel opinion, stapled hemorrhoidopexy represents the gold-standard treatment for grade 3 hemorrhoidal prolapse.