Gastrointestinal stromal tumors (GIST) because of its rarity continues to be a curiosity for radiologists, surgeons and pathologist. These tumors are usually found in gastrointestinal tract (GIT) but account for less than 1% of GIT tumors. A 35-year-old male presented to us with complaints of painful micturation which on radiologic evaluation revealed a large mass in relation to urinary bladder. The tru-cut biopsy reported a low grade soft tissue tumour. The said mass was excised on laparotomy and sent for histopathological examination which reported as high grade GIST or a pleomorphic sarcoma as possibilities. Immuno-histochemistry finally confirmed the diagnosis of a GIST with CD 34 positive and C-Kit negative status. Approximately, 95% of GIST tumors are C-Kit positive and hardly 5% are C-Kit negative. C-Kit negative status makes this case report more worth reporting.
Gastrointestinal Stromal Tumors

Signet ring cell adenocarcinomas may be encountered in various parts of gastrointestinal tract but are almost unheard of in the region of ampulla of vater. In the region of ampulla of vater even if we come across an adenocarcinoma, it is usually a well differentiated variant. A 56-year-old female with features of obstructive jaundice on evaluation was diagnosed to have a peri-ampullary carcinoma.The patient was subjected to a laparotomy. On exploration patient was found to have a malrotation of gut. Patient was subjected to a pylorus preserving pancreatico-duodenectomy. Histopathology of the resected specimen revealed a signet ring morphology which is a rare variant in periampullary region.
Adenocarcinoma ; Carcinoma, Signet Ring Cell