1.Genetic Variations in Attention Deficit Hyperactivity Disorder Subtypes and Treatment Resistant Cases.
Dilek UNAL ; Mehmet Fatih UNAL ; Mehmet ALIKASIFOGLU ; Arda CETINKAYA
Psychiatry Investigation 2016;13(4):427-433
OBJECTIVE: ObjectiveaaWe evaluated the distribution of alpha-2A adrenergic receptor (ADRA2A) and catechol-o-methyltransferase (COMT) single nucleotide polymorphisms (SNPs) among ADHD subtypes and other homogeneous patient populations including treatment-resistant cases and patients with high symptom severity. METHODS: Methodsaa121 ADHD patients aged 6-18 years were included in the study. Diagnosis and subtypes designation were confirmed using the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) and symptoms were evaluated using the Conners' Parent (CPRS) and Teacher Rating Scales (CTRS). The response to methylphenidate was assessed objectively using the Clinical Global Impression-Severity Scale (CGI-S) and Global Assessment of Functioning Scale (GAS) as well as the Continuous Performance (CPT) and Trail Making tests (TMT-A, B). Patients were genotyped for ADRA2A (rs1800544) and COMT (rs4680) SNPs by PCR/RFLP and compared to a gender-matched control group. RESULTS: Although there was no association of COMT (rs4680) SNP with symptoms or diagnosis, the ADRA2A polymorphism, low socioeconomic status (SES), and comorbid psychiatric diagnosis were all associated with poor response to methylphenidate in logistic regression analysis. CONCLUSION: Clinicians may consider adjuvant strategies when these negative factors are present to increase the success of tailored ADHD treatments in the future.
Appointments and Schedules
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Attention Deficit Disorder with Hyperactivity*
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Catechol O-Methyltransferase
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Diagnosis
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Genetic Variation*
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Genetics
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Humans
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Logistic Models
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Mental Disorders
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Methylphenidate
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Mood Disorders
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Parents
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Phenotype
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Polymorphism, Single Nucleotide
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Receptors, Adrenergic, alpha-2
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Schizophrenia
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Social Class
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Trail Making Test
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Weights and Measures
2.Evaluation of Oxidative Metabolism in Child and Adolescent Patients with Attention Deficit Hyperactivity Disorder.
Muslum KUL ; Fatih UNAL ; Hasan KANDEMIR ; Bahram SARKARATI ; Kamer KILINC ; Sultan Basmaci KANDEMIR
Psychiatry Investigation 2015;12(3):361-366
OBJECTIVE: Oxidative metabolism is impaired in several medical conditions including psychiatric disorders, and this imbalance may be involved in the etiology of these diseases. The present study evaluated oxidative balance in pediatric and adolescent patients with attention deficit hyperactivity disorder (ADHD). METHODS: The study included 48 children and adolescents (34 male, 14 female) with ADHD who had no neurological, systemic, or comorbid psychiatric disorders, with the exception of oppositional defiant disorder (ODD), and 24 sex- and age-matched healthy controls (17 male and seven female). RESULTS: TAS was significantly lower, and TOS and OSI were significantly higher in patients with ADHD than in healthy controls. Total antioxidant levels were lower in patients with comorbid ODD than in those with no comorbidity. No difference was found in TOS or OSI among the ADHD subtypes; however, TAS was higher in the attention-deficient subtype. CONCLUSION: Our findings demonstrated that oxidative balance is impaired and oxidative stress is increased in children and adolescents with ADHD. This results are consistent with those of previous studies.
Adolescent*
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Attention Deficit and Disruptive Behavior Disorders
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Attention Deficit Disorder with Hyperactivity*
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Child*
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Comorbidity
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Humans
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Male
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Metabolism*
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Oxidative Stress
3.Intraparenchymal Methylene Blue Injection for Sentinel Lymph Node in Breast Cancer Patients does not Interfere with the Pulse Oximetry Readings.
Fatih AYDOGAN ; Ziya SALIHOGLU ; Cihan URAS ; Ilhan KARABICAK ; Varol CELIK ; Ali CERCEL ; Semih BAGHAKI ; Ufuk TOPUZ ; Deniz ATASOY ; Rovnat BABAZADE ; Hilal UNAL
Journal of Breast Cancer 2009;12(1):32-35
PURPOSE: Alteration in oxygen saturation is a side effect of the dye used in sentinel lymph node biopsy. The object of this study was to determine the possible effects of methylene blue on the oxygen saturation in patients undergoing sentinel lymph node biopsy. METHODS: The complete peroperative records of 148 patients who underwent sentinel lymph node biopsy with intraparenchymal injection of methylene blue were reviewed. The data reviewed included the preinjection pulse oximeter saturation readings and the postinjection values until the readings returned to the preoperative levels in the postanesthesia care unit. RESULTS: The pulse oximetry values were recorded preoperatively, after intubation and, at 15, 30, 45, and 60 minutes of the operation. The results showed that methylene blue did not cause any significant changes in oxygen saturation levels. CONCLUSION: We suggest that methylene blue might be preferable for the patients with concomitant disease, and for whom close monitoring of their oxygen saturation is required.
Breast
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Breast Neoplasms
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Humans
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Intubation
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Lymph Nodes
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Methylene Blue
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Nitriles
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Oximetry
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Oxygen
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Pyrethrins
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Reading
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Sentinel Lymph Node Biopsy
4.Increased Bladder Wall Thickness in Diabetic and Nondiabetic Women With Overactive Bladder.
Hakki UZUN ; Sabri OGULLAR ; Serap Baydur SAHIN ; Orhan Unal ZORBA ; Gorkem AKCA ; Fatih SUMER ; Ulku Mete GUNEY ; Gulsah BALIK
International Neurourology Journal 2013;17(2):67-72
PURPOSE: Bladder wall thickness has been reported to be associated with overactive bladder (OAB) in women. Diabetic women have an increased risk for OAB syndrome and may have an increased risk for bladder wall thickness. METHODS: A total of 235 female patients aged 40 to 75 years were categorized into four groups. The first group consisted of women free of urgency or urge urinary incontinence. The second group included nondiabetic women with idiopathic OAB. The third group consisted of women with diabetes and clinical OAB, and women with diabetes but without OAB constituted the fourth group. Bladder wall thickness at the anterior wall was measured by ultrasound by the suprapubic approach with bladder filling over 250 mL. RESULTS: The diabetic (third group) and nondiabetic (second group) women with OAB had significantly greater bladder wall thickness at the anterior bladder wall than did the controls. However, the difference was not significant between the diabetic (third group) and the nondiabetic (second group) women with OAB. Women with diabetes but without OAB (fourth group) had greater bladder wall thickness than did the controls but this difference was not significant. Additionally, the difference in bladder wall thickness between diabetic women with (third group) and without (fourth group) OAB was not significant. CONCLUSIONS: This is the first study to show that bladder wall thickness is increased in diabetic women with and without OAB. Additionally, nondiabetic women with OAB had increased bladder wall thickness. Further studies may provide additional information for diabetic and nondiabetic women with OAB, in whom the etiopathogenesis of the disease may be similar.
Aged
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Diabetes Mellitus
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Female
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Humans
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Urinary Bladder
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Urinary Bladder, Overactive
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Urinary Incontinence