OBJECTIVE: The results of epidemiological studies investigated the association between polycystic ovary syndrome (PCOS) and the breast cancer are inconsistent. This meta-analysis was conducted to estimate the association between PCOS and the breast cancer risk. We searched PubMed, Web of Science, and Scopus for observational studies until June 2015. Data were independently extracted and analyzed using 95% odds ratio, and confidence intervals (CIs) based on the random-effects models. METHODS: We identified 970 references and conducted eight studies with 45,470 participants and 243,064 person- year. RESULTS: The association between PCOS and the breast cancer risk in case-control studies 0.87 (95% CI, 0.44 to 1.31) and that of cohort studies was estimated 1.18 (95% CI, 0.93 to 1.43). CONCLUSION: This meta-analysis demonstrated that PCOS no does increase the risk of breast cancer. Further prospective cohort studies are needed to provide convincing evidence in order to PCOS can increase or not effect on the risk of the breast cancer.
Breast Neoplasms* ; Breast* ; Case-Control Studies ; Cohort Studies ; Epidemiologic Studies ; Odds Ratio ; Polycystic Ovary Syndrome* ; Prospective Studies

OBJECTIVE: The results of epidemiological studies investigated the association between polycystic ovary syndrome (PCOS) and the breast cancer are inconsistent. This meta-analysis was conducted to estimate the association between PCOS and the breast cancer risk. We searched PubMed, Web of Science, and Scopus for observational studies until June 2015. Data were independently extracted and analyzed using 95% odds ratio, and confidence intervals (CIs) based on the random-effects models. METHODS: We identified 970 references and conducted eight studies with 45,470 participants and 243,064 person- year. RESULTS: The association between PCOS and the breast cancer risk in case-control studies 0.87 (95% CI, 0.44 to 1.31) and that of cohort studies was estimated 1.18 (95% CI, 0.93 to 1.43). CONCLUSION: This meta-analysis demonstrated that PCOS no does increase the risk of breast cancer. Further prospective cohort studies are needed to provide convincing evidence in order to PCOS can increase or not effect on the risk of the breast cancer.
Breast Neoplasms* ; Breast* ; Case-Control Studies ; Cohort Studies ; Epidemiologic Studies ; Odds Ratio ; Polycystic Ovary Syndrome* ; Prospective Studies

OBJECTIVES: This study aimed to investigate the effect of Educational program on quality of life (QOL) in menopausal women in 2016 in Hamadan, Iran. METHODS: In this clinical trial study, 100 postmenopausal women were randomly selected and allocated to case and control group (50 per group). Data collection tool included questionnaires of demographic information and Menopause QOL, which were completed by the samples before the intervention. In the case group, education program was run during 5 sessions for 45 to 60 minutes. Immediately and Three months after intervention, information were collected using questionnaire in both groups and they were analyzed using SPSS 16 software. RESULTS: The menopause women in both intervention and control groups had similar demographics. There was not a significant difference in the QOL mean scores in before of the intervention between the two groups of intervention and control in all dimension of QOL. There was a significantly difference in the mean of QOL scores between the two groups in immediately after the intervention and 3 months after the intervention in dimension of vasomotor, psychosocial, sexual and physical (P < 0.001). CONCLUSIONS: This study recommend that a unit in health and treatment centers be established for training menopausal women about health care by holding didactic classes.
Data Collection ; Delivery of Health Care ; Demography ; Education ; Female ; Humans ; Iran ; Menopause ; Quality of Life*

OBJECTIVES: Menopause can have psychological, physical, and vasomotor symptoms along with sexual dysfunction and these symptoms can affect the quality of life (QOL). The purpose of this research was to determine and association the effective factors on QOL among postmenopausal Iranian women. METHODS: This cross-sectional study was conducted in 2015 on 300 postmenopausal women in Hamadan, Iran. We used the Menopause-Specific QOL questionnaire (MENQOL) for measuring QOL in postmenopausal women. SPSS version 16 was used for data analysis. RESULTS: The mean scores of QOL for vasomotor, psychosocial, physical, and sexual domains were 11.65 ± 5.93, 19.36 ± 1.20, 39.12 ± 1.95 and 11.02 ± 5.66, respectively. Higher scores had worse QOL. Using MENQOL scores, our study showed significant differences in QOL based on age, education level, financial status, number of children, employment, and body mass index (BMI). CONCLUSION: Menopause causes a decrease in QOL, which is dependent to age, work, BMI, financial status and number of children variables. Therefore, it is necessary to develop effective intervention programs to improve QOL in postmenopausal women.
Body Mass Index ; Child ; Cross-Sectional Studies ; Education ; Employment ; Female ; Humans ; Iran* ; Menopause ; Quality of Life* ; Statistics as Topic

OBJECTIVES: The association between body mass index (BMI) and hot flash risk has not been specifically clarifies yet. This meta-analysis was, therefore, conducted to estimate the association between overweight and obesity and hot flash risk. METHODS: We searched PubMed, Web of Science, and Scopus for observational studies addressing the association between BMI and hot flash until August 2015. Data were independently extracted and analyzed using 95% odds ratio (OR), and confidence intervals (CI) based on the random-effects models. RESULTS: We identified 2,244 references and conducted seven studies with 4,219 participants. The association between hot flash and overweight was estimated 1.13 (95% CI: 0.97-1.32) and that of obesity was estimated 1.79 (95% CI: 1.52-2.11). No evidence of heterogeneity and publication bias was observed. CONCLUSION: This meta-analysis demonstrated that, though not to a great extent, obesity does increase the risk of hot flash. The findings from this meta-analysis indicated that obesity is associated with an increased risk of hot flash. Further large prospective cohort studies are required to provide convincing evidence as to whether or not BMI is associated with an increased risk of hot flashes.
Body Mass Index* ; Case-Control Studies ; Cohort Studies ; Female ; Hot Flashes ; Humans ; Obesity ; Odds Ratio ; Overweight ; Population Characteristics ; Prospective Studies ; Publication Bias

OBJECTIVE: Premenstrual syndrome (PMS) affects millions of women and is known as the most important disorder among them. The very aim of the present study was to evaluate the effects of low dose calcium on severity of PMS. METHODS: This study can be considered as a double-blind randomized clinical trial. Female students of Hamadan University of Medical Sciences diagnosed with PMS in 2014 participated in the present study. Sixty-six female students diagnosed with PMS were involved in the experimental and control groups. The participants were randomly assigned into two groups to receive 500 mg of calcium daily or placebo for two months. Severity of PMS was detected by Daily Record of Severity of Problems, which was used to measure symptoms during one menstrual cycle before and two menstrual cycles after the intervention. RESULTS: No signifcant differences were observed in the mean scores of PMS symptoms between calcium and placebo groups before the treatment (P=0.74). However, signifcant differences were noticed between the two intervention groups in the first (P=0.01) and second menstrual cycles (P=0.001) after the intervention. The differences were significant in subgroups of anxiety, depression, emotional changes, water retention, and somatic changes in calcium group compared with placebo group in the menstrual cycle before the intervention and two menstrual cycles after the intervention and among menstrual cycles (0, cycle 1, cycle 2) in calcium group (P=0.01). CONCLUSION: Overall, the results of the present study suggest that treatment with calcium supplements is an effective method for reducing mood disorders during PMS.
Anxiety ; Calcium* ; Depression ; Female ; Humans ; Menstrual Cycle ; Methods ; Mood Disorders ; Premenstrual Syndrome* ; Water

OBJECTIVE: Primary dysmenorrhea occurs in more than 50% of women of reproductive age. This survey evaluated the effects of Menstrugole on the alleviation of primary dysmenorrhea. METHODS: This study was performed in western Iran between August 15 and December 15, 2017, in female students with primary dysmenorrhea. The students were randomly divided into 2 groups and received placebo or a Menstrugole capsule for 3 days in each of 2 menstrual cycles. The visual analog scale was used to assess pain severity. The χ2 test, one-way analysis of variance, and the paired t-test were used for statistical evaluation. RESULTS: We compared the severity of pain between the 2 groups. There was a significant change in the mean pain score during the first (P < 0.001) and second months (P < 0.001) after the use of Menstrugole, compared with that in the placebo group. CONCLUSION: Menstrugole decreased pain severity in female students, and can be considered by health care providers for treatment of primary dysmenorrhea.
Adolescent ; Analgesics ; Dysmenorrhea* ; Female ; Health Personnel ; Humans ; Iran ; Menstrual Cycle ; Visual Analog Scale

Objective: To assess prevalence of cyclical mastalgia and its main determinants in women who attended in health centers of Hamadan City, Iran. Methods: This case-control study was conducted on 400 women (case: cyclical mastalgia, n = 240; control: without cyclical mastalgia, n = 160) who attended family planning clinic for routine follow-up in health centers. The cluster sampling was used. Information was collected by interviewing and using a standardized validated questionnaire. Severity of mastalgia was assessed through using visual analog scaling. Data processing and statistical analysis were performed by using SPSS 19.0. Results: The results revealed that majority of women (60.0%) experienced cyclical mastalgia. Out of these, 22.5% and 37.5% were mild and moderate-to-severe mastalgia, respectively. No association was revealed in experience of depression and anxiety in mastalgia group. In a multivariable logistic regression model, the increasing age, age of marriage, history of abortion and history of premenstrual syndrome were main determinants of mastalgia, while use of oral contraceptive and regular exercise was associated with lower incidence of mastalgia. Conclusions: Most of women with breast discomfort suffered cyclical mastalgia which severity can be determined by advanced age, age of marriage, history of abortion and history of premenstrual syndrome, but inversely by oral contraceptive use and exercise activity.