Objective To evaluate the effect of sufentanil combined with dexmedetomidine on analgesia in patients with pulmonary lobectomy.Method Totally 80 patients with pulmonary lobectomy in Yanan University Affiliated Hospital were collected from January 2014 to August 2016,which randomly divided into two groups:patients in control group (n-40) were given sufentanil 0.05 μg/(kg·h),and patients in observation group (n =40) were given sufentanil 0.03 μg/(kg·h) combined with dexmedetomidine 0.07 μg/(kg·h),The differences of hemodynamic change,VAS and Ramsay score,and adverse reaction at 1 h,6 h,12 h,24 h and 48 h after operation were compared.Results The hemodynamic change of all patients were relatively stable,and the more stable group B with lower MAP,HR and DBP at 12 h,and SBP at 6 h after operation further contributed the recovery of patients,which difference compared with group A was significance (P ＜ 0.05).However,the difference of SpO2 at the same time after operation was no significance.The VAS score blow 4 showed that the analgesia of all patients was satisfying.Comparing group B with group A,the VAS score was lower after 6 h at post-operation,which difference was significance (P ＜ 0.05).The Ramsay score of group B was higher than group A at 6h and 12 h,which difference was significance (P ＜ 0.05).The Ramsay score with range from 2 to 4 showed the sedation of all patients was not deficient or excessive.The incidence of nausea and vomit (2.5％) and dizziness (0％) in group B was lower than group A,with significant difference between two groups (P ＜ 0.05).Conclusion Combination dexmedetomidine with sufentanil to relief postoperative pain in patients undergoing pulmonary lobectomy is deserved popularization in clinic,which not only increases the efficiency analgesia and sedation,improves hemodynamic,but also decreases sufentanil-induced side-effect.