1.Application of SWI in the diagnosis of mild traumatic brain injury
Dihong CHEN ; Fangyuan REN ; Xinbin WANG ; Cuncheng LOU ; Canyun WANG ; Yuan LIU
Chinese Journal of Primary Medicine and Pharmacy 2018;25(23):3046-3049
Objective To investigate the diagnostic value of susceptibility weighted imaging ( SWI) in patients with mild traumatic brain injury(MTBI).Methods From June 2016 to October 2017,a retrospective analysis of 89 patients with MTBI (Glasgow score 13 to 15) in the First People's Hospital of Xiaoshan District was conducted.All patients were given head CT ,MRI and SWI within 1 week after admission.Combined with CT and phase diagram ,after removing blood vessels ,calcification and skull base artifact ,the low signal intensity on the SWI was cerebral contusion and hemorrhage.The sites,the number and the size of lesion detected on CT ,MRI and SWI images were recorded and analyzed with clinical symptoms.Results According to the presence or absence of clinical symptoms in the group ,the detection rates of microbleeds hemorrhage in patients with traumatic cerebral by SWI were 94.4%,54.2%,100.0%, 95.5%,respectively,which were higher than those by CT (16.6%,4.2%,15.0%,4.5%) and MRI conventional sequences(33.3%,8.3%,20.0%,13.6%),the differences were statistically significant (χ2=6.633,P=0.010;χ2=4.260,P=0.039,all P <0.05),especially in MTBI patients with a history of transient coma or persistent clinical symptoms after trauma(the detection rate was 100.0%).Conclusion Compared with conventional CT and MRI,the micro-contusion and small hemorrhagic lesions of SWI is more accurate and important in the diagnosis of MTBI,and has a significant prognostic value for clinical treatment and judgment of patients with MTBI .
2.Experiences of patients with hematologic neoplasm regarding T-cell immunotherapy:a meta-synthesis review and inspiration for nursing care
Ying HUANG ; Huafen WANG ; Lifang SHAO ; Li ZHENG ; Danping SUN ; Fangyuan LOU ; Xiaofei YAO
Chinese Journal of Nursing 2024;59(17):2147-2155
Objective This study aims to systematically evaluate the experiences of patients with hematologic neoplasm undergoing chimeric antigen receptor T-cell(CAR-T)therapy and nursing care,and to provide a reference basis for healthcare providers to develop personalized intervention strategies.Methods PubMed,Web of Science,Embase,CINAHL,Cochrane Library,PsycINFO,Scopus,Australia Joanna Briggs Institute(JBI)EBP Database,China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP Database,and China Biology Medicine(CBM)Database were systematically searched for qualitative studies on the experiences of patients with hematologic neoplasm undergoing CAR-T therapy and nursing care.The search period extended up to September 2023.The quality of the literature was reviewed according to the JBI Qualitative Assessment and Review Instrument,and a pooled analysis was applied to integrate the results.Results A total of 15 studies were included,generating 76 findings,which were then organized into 8 categories,resulting in 3 integrated findings.(1)Patients experienced conflicting emotions,with expectations often at odds with reality,leading to emotional fluctuations:expectations about treatment were entangled with concerns about risks;emotions fluctuated with expectations and actual experiences.(2)Patients experienced physical and social functional impairments,but as the disease eased,normal functioning recovered:rapid decline and improvement in physical functions;loss and recovery of social functions.(3)Patients desired access to professional guidance and psychosocial support.Conclusion Patients undergoing CAR-T therapy often contend with emotional conflicts.Changes in physical and social functions after the completion of treatment result in needs for seeking comprehensive medical and nursing support.It is recommended that healthcare providers conduct dynamic assessments and interventions regarding patients'emotional states before treatment,focus on early identification and management of adverse reactions after treatment,and offer continuous nursing services after discharge to enhance patients'confidence in participating in CAR-T therapy and improve their overall quality of life.