Objective To investigate the effects of Astragalus polysaccharide (APS) on damage of keratinocytes in ultraviolet B (UVB) radiation skin in HaCaT cells; To preliminarily explore its mechanism of action.Methods HaCaT cells were treated by UVB irradiated for modeling. Blank control group, model group, UVB irradiation group and low-, medium- and high-dose APS interventional groups were set up. Each medication group was given relevant medicine. MTT assay was used to determine the cell activity; GSH-Px, CAT, SOD activity and MDA content were detected by biochemical colorimetric method; contents of TNF-α and IL-6 were detected by ELISA.Results Compared with the control group, the contents of SOD, CAT and GSH-Px in the model group decreased significantly, while the contents of MDA, TNF-α and IL-6 increased significantly (P<0.05); compared with the mode group, the contents of SOD, CAT and GSH-Px in the medication groups increased significantly, while the contents of MDA, TNF-α and IL-6 were reduced significantly (P<0.01).Conclusion APS can reduce the oxidative stress injury of UVB to HaCaT cells to some extent.

Objective We observed the effect of dexamethasone ointment on preventing phlebitis induced by vinorelbine. Methods Patients with malignant tumor who received chemotherapy of vinorelbine through peripheral superficial vein injection were divided into the observation group (70 cases) and the control group (72 cases) according to the date of hospitalization. All patients received vinorelbine four times averagely. Patients in the observation group was given dexamethasone ointment along punctured superficial vein. Patients in the control group received routine nursing measure. The incidence rate, time and degree of phlebitis was compared between these groups. Results The incidence rate and degree of phlebitis was lower than those of the control group (P< 0.01, P< 0.05). The incidence time of phlebitis in the observation group was also later than that of the control group (P<0.05). Conclusion Local application of dexamethasone ointment could effectively reduce the incidence of superficial phlebitis caused by vinorelbine chemotherapy.

Using cyproheptadine ( CYP) as template molecule, methacrylic acid ( MAA) as monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linker, molecularly imprinted polymers (MIP) with high selectivity to cyproheptadine (CYP) were prepared by the optimization of porogen, monomer, and the mole ratio of monomer to template. The specific surface area of the prepared polymers was 24. 9 m2 / g. The recovery of CYP was above 94. 0% when the following procedure was applied to the cartridge of MIP as adsorptive material: conditioning with methanol and water, loading with water, washing with water and methanol, and eluting with methanol-ammonia (95: 5, V/ V). As a control, the recovery of CYP on non-imprinted polymers cartridge (NISPE) was only 38. 9% . The binding capacity of the molecularly imprinted solid phase extraction (MISPE) towards CYP found to be about 8. 8 mg of CYP/ g polymers and the imprinting factor (IF) was about 2. 32. Under optimal conditions, a mixed standard solution of CYP, amitriptyline, sulfadiazine and trimethoprim (10 mg / L each) was uploaded on the MISPE and NISPE for selectivity experiment. The gradient elution was used by using 0. 05% sodium pentanesulfonate solution (A)-acetintrile (B) as a mobile phase. The recoveries on the MISPE for sulfadiazine and trimethoprim (different structure with CYP) were less than 10% , however, the recovery for the similar structural amitriptyline was more than 70% , and the recovery more than 90% for CYP. All the recoveries on the NISPE for four analytes were less than 30% . This new MISPE cartridge was applied to extract and enrich CYP in livestock drinking water sample, and the recoveries of CYP ranged from 80. 5% -97. 7% , and the limit of detection (LOD) was 0. 01 mg / L.

Objective To evaluate the feasibility and safety of prostatic artery embolization (PAE)via transradial approach in treating prostatic hyperplasia.Methods The clinical data of 18 patients with prostatic hyperplasia,who received C-arm CT-guided PAE via left or right radial artery access,were retrospectively analyzed.The following indexes were recorded:arterial spasm and injury of upper limbs,incidence of puncture point bleeding,postoperative radial artery pulse and congestion,blood supply and nerve injury of fingers,the surgical success rate,incidence of perioperative cerebral vascular complications,operation time,radiation dose and clinical curative effect.Results Among the 18 patients,PAE via left radial artery access was employed in 14,and PAE via right radial artery access was performed in 4.Bilateral PAE was carried out in 16 patients,and only unilateral PAE was able to be successfully accomplished in 2 patients as the prostatic artery opening of the other side was tortuous with stenosis.After PAE,decreased radial pulse was observed in one patient and ultrasound examination revealed decreased blood flow.The operation time ranged from 96 min to 245 min.The radiation dose received by the patient varied from 2435 mGy to 4958 mGy with a mean of (3342±156) mGy,which was not significantly different from the radiation dose received by the patients who underwent PAE via femoral artery access during the same study period (P=0.1167).Conclusion In treating prostatic hyperplasia,PAE by using transradial approach is clinically safe and technically feasible.

Objective To evaluate the acceptance of the Mobile Delirium Assessment App based on confusion assessment method for intensive care unit (CAM-ICU )nurses.Methods Using the technology acceptance model as the theoretical framework to design the user acceptance questionnaire,1 03 ICU nurses were selected by convenient sampling to participate in the study from 5 level three class A hospitals in Beijing from October 201 5 to January 201 6.Results Effective collected 1 01 questionnaires showed that the average scores of each dimensions intelligentized CAM-ICU delirium assessment system included perceived usefulness(4.62 ± 0.44)points,perceived ease of use(4.31 ±0.39)points,perceived ease of adoption(4.28 ±0.49)points,trust (4.36 ±0.62)points,attitude toward use (4.46 ±0.50)points and behavioral intention to use (4.61 ± 0.52)points.There were differences in perceived ease of use,trust and attitude toward use among nurses with different ages and different length of service (P <0.05 ).Pearson correlation analysis showed a positive correlation between perceived usefulness,perceived ease of use,trust and attitude toward use (P <0.01 ).A positive correlation was between perceived usefulness,perceived ease of use,attitude toward use and behavioral intention to use (P <0.05).A positive correlation was between perceived usefulness and perceived ease of use (P <0.01 ).Conclusions The acceptance of intelligentized CAM-ICU is satisfactory in ICU nurses,and which examine the from the simple and ease to use of delirium evaluation system subjective view.With the increasing of age and working years in ICU nurses,the acceptance increase for intelligentized CAM-ICU.Except the ease to learn,the correlation analysis showed the correlations in each dimensions are in accordance of hypnosis of theory model.

With the widespread application of medical big data and the rapid development of nursing informatics, the application of big data in the service of nursing science induces high attention of nursing field. From the perspective of the concept of big data and their characteristics, this paper explained the technique of big data and its processing flow in details. Combined with five application fields of medical big data, this paper not only summarized the application situation of big data in nursing field, but discussed and analyzed the development prospect of nursing big data and its difficulty, which offers reference for the nursing academic circle.

Objective To investigate the current status of ICU delirium management so as to provide reference for the clinical management of ICU delirium.Methods A total of 6 ICU units from two class Ⅲ grade A hospitals in Beijing were selected by convenient sampling. The spot investigation method was used to investigate the delirium management status and effect from June to September 2016.Results Six ICU units had neither developed a complete delirium management system and standardized process, nor systematically evaluated delirium risk factors. When delirium patients had symptoms, delirium was diagnosed according to the clinical experience in 6 ICU units, while specialist consultation was used in 3 ICU units. None of these units used any delirium screening tool. The delirium prevention rate was from 46.2% to 76.9%. The implementation rate of delirium treatment was 65.8%. Among 38 cases of delirium patients diagnosed by medical staff, 25 cases (65.8%) of which were treated. During the study, there were 106 cases of delirium patients; the incidence of delirium was 30.8%; the delirium identification rate of medical staff was 35.8%.Conclusions The normalization of routine monitoring of delirium in ICU is necessary. Prevention and treatment for delirium is inadequate. The effect of delirium management needs to be further improved.

Objective?To determine and analyze the problems of nurses during using printed Intensive Care Delirium Screening Checklist (ICDSC) for evaluating through user requirements analysis, which is necessary for information systems development, so as to provide a basis for developing an ICDSC interactive strategy. Methods?Two methods, the documentation method and task check method, were used to analyze user requirements of printed ICDSC. The retrieval words of documentation method were "ICDSC" and "intensive care delirium screening checklist". This study retrieved documents on using and evaluation of ICDSC publishing in PubMed, Springer, Elsevier, CNIAHL, CNKI and WanFang Data from January 2000 to December 2017. The find what focused on description related to problems of Intensive Care Unit (ICU) nurses during using printed ICDSC. The task check method was used to select ICU nurses as user representatives to assess delirium of four patients cases provided by researchers using printed ICDSC. Each case all perfectly completed 8 appraising tasks from ICDSC assessments. Researchers observed and recorded problems of ICU nurses during fulfilling the task. Nurses' sample size was based on information saturation (till no new information occurred). Results?A total of 7 articles among 144 ones retrieved referred to problems of nurses during using printed ICDSC to assess delirium including time-consuming, failing to understand items, deficiency/inaccuracy in nursing record. A total of 15 ICU nurses were selected in task check method. Results showed that the problems included time-consuming, omitting items, failing to understand items, scoring mistakenly, deficiency/inaccuracy in nursing record. Conclusions?There are problems such as time-consuming, omitting items, failing to understand items, scoring mistakenly and assessed information without inaccurate source in using printed ICDSC. The interactive strategy should be developed according to these problems.

Objective:To systematically evaluate effects of mobile health intervention on blood pressure control in stroke patients.Methods:PubMed, Embase, CINAHL, PsycINFO, the Cochrane Library, Sinomed, CNKI and Wanfang databases were searched by computer. The search time was from the establishment of databases to October 31, 2020. Two researchers independently searched and screened out RCTs that used Mobile Health to intervene blood pressure in stroke patients according to the inclusion and exclusion criteria of the literature. The revised version of the risk assessment tool for bias was used to evaluate quality of included literatures, and RevMan 5.3 was used to perform a meta-analysis on the extracted data.Results:A total of 5 articles were included, including 1 209 study subjects. Meta-analysis results showed that compared with conventional care, mobile health could reduce the systolic blood pressure of stroke patients [ WMD= -3.59, 95% CI: (-6.00--1.18) , P=0.004]and diastolic blood pressure [ WMD=-3.38, 95% CI: (-5.16- -1.60) , P=0.000 2]. Conclusions:Mobile health is better than conventional care in blood pressure control for stroke patients, but more high-quality RCT studies are still needed to further verify the conclusions in the future. Mobile health is expected to become an effective means to help stroke patients manage their blood pressure in the long-term.

Background:Nonalcoholic fatty liver disease(NAFLD)is the liver manifestation of metabolic syndrome,and may be related with the incidence of colorectal polyps. However,studies on the correlation between NAFLD and colorectal polyps are rare. Aims:To investigate the correlation between NAFLD and colorectal polyps. Methods:Clinical data of 130 asymptomatic patients accepted physical examination were retrospectively analyzed. Detection rates of NAFLD and colorectal polyps were evaluated,and the correlations with body mass index(BMI),hs-CRP,triglyceride,low density lipoprotein,total cholesterol,alanine aminotransferase(ALT),glutamyltranspeptidase(GGT)were analyzed. Results:Compared with non-NAFLD patients,the detection rate of colorectal polyps in NAFLD patients was significantly increased (66.3% vs. 40.0%,P=0.003 9),BMI,triglyceride and ALT were significantly increased(P<0.05). However,no significant differences in hs-CRP,low density lipoprotein,total cholesterol and GGT were found between NAFLD and non-NAFLD patients. Compared with non-colorectal polyps patients,the average age of patients with colorectal polyps was higher(P =0.013),and detection rate of NAFLD was significantly increased(72.6% vs. 47.4%,P =0.003 9). However,no significant differences in BMI,hs-CRP,triglyceride,low density lipoprotein,total cholesterol,ALT,GGT were found between colorectal polyps group and non-colorectal polyps group(P>0.05). Conclusions:NAFLD may be closely correlated with the incidence of colorectal polyps.