Aim To investigate the influence of intranasal delivery of calcitonin gene-related peptide(CGRP)on cerebral blood supply and expression of vascular endothelial growth factor(VEGF)following experimental subarachnoid hemorrhage(SAH).Methods Wistar rats were divided into normal control group,SAH group,intranasal normal saline(NS)+SAH group and intranasal CGRP+SAH group.SAH models were produced by double injection of autologous arterial blood into cisterna magna.CGRP and NS were given by intranasal perfusion.Dynamic observations of regional cerebral blood flow(rCBF)of cerebral cortex were made using a laser Doppler flowmeter probe.On the third day after the second cisternal injection,the expression of VEGF protein in cerebral cortex was observed by immunofluorescence method combined with laser confocal microscopic observation.Results Anatomic observation revealed that SAH models were successfully manufactured.In SAH and intranasal NS+SAH groups,a drastic and persistent drop in rCBF was noted during the observed periods.The decrease of rCBF in intranasal CGRP+SAH group was slighter as compared with that in SAH and intranasal NS+SAH groups.In SAH and intranasal NS+SAH groups,increased expression of VEGF protein in cerebral cortex was observed on the third day after second cisternal injection as compared with that in normal control group.The expression of VEGF in intranasal CGRP+SAH group was more obvious than that in intranasal NS+SAH group.Conclusion Intranasal delivery of CGRP improves cerebral blood supply and promotes angiogenesis by enhancing the expression of VEGF after SAH.

Objective To investigate the effect of evidence-based pain nursing on postoperative pain and wound healing in hemorrhoids patients with hemorrhoid surgery. Methods A total of120 hemorrhoid cases treated from January to April 2018 in our hospital were randomly divided into observation group and control group. The control group (n = 60) received routine nursing during perioperative period, another 60 cases in the observation group were treated with evidence-based pain nursing on the basis of routine nursing. The postoperative pain and wound healing were compared between the two groups. Results The 24, 48 h pain scores as well as highest pain score of the observation group were all lower than that of the control group (P ＜ 0. 05). The pain scores of the first dressing change and the first bowel movement were lower than that of the control group (P ＜ 0. 05).The edema scores of the observation group at 24 and 48 hours after operation were lower, the wound score before discharge was lower, and the wound healing time was shorter than that of the control group (P ＜ 0. 05). Conclusion Evidence-based nursing can reduce postoperative pain degree, reduce wound edema and promote healing of hemorrhoid patients.

Objective To investigate the effect of evidence-based pain nursing on postoperative pain and wound healing in hemorrhoids patients with hemorrhoid surgery. Methods A total of120 hemorrhoid cases treated from January to April 2018 in our hospital were randomly divided into observation group and control group. The control group (n = 60) received routine nursing during perioperative period, another 60 cases in the observation group were treated with evidence-based pain nursing on the basis of routine nursing. The postoperative pain and wound healing were compared between the two groups. Results The 24, 48 h pain scores as well as highest pain score of the observation group were all lower than that of the control group (P ＜ 0. 05). The pain scores of the first dressing change and the first bowel movement were lower than that of the control group (P ＜ 0. 05).The edema scores of the observation group at 24 and 48 hours after operation were lower, the wound score before discharge was lower, and the wound healing time was shorter than that of the control group (P ＜ 0. 05). Conclusion Evidence-based nursing can reduce postoperative pain degree, reduce wound edema and promote healing of hemorrhoid patients.