1.Lowing-IOP effect of endoscopic cyclophotocoagulation combined with phacoemulsification and IOL in rabbit chronic glaucomatous eye
Yunjiang, ZHANG ; Fangliang, YU ; Guofu, HUANG ; Miao, LIU
Chinese Journal of Experimental Ophthalmology 2015;33(3):232-236
Background Endoscopic cydophotoeoagulation (ECP) combined with phacoemulsification (Phaco) and intraocular lens (IOL) (ECP+Phaco+IOL) surgery has been widely used,but its lowing intraocular pressure (IOP) effect is unclear.Objectives This study was to investigate the lowing-IOP effect of ECP+Phaco+ IOL in chronic glaucoma.Methods This experimental process was approved by Experimental Animal Ethics Committee of Medical College of Nanchang University.Chronic glaucoma models were established bilateral eyes of 30 pigmented rabbits using laser 360°trabecular meshwork photocoagulation.Forty-eight model eyes were randomized to four groups.ECP of 180°,270° and 360° was performed in the A,B and C groups,respectively,and Phaco+IOL was simultaneously carried out;while trabeculectomy (Trab) combined with Phaco+IOL surgery (Trab+ Phaco+IOL) was performed in the D group.IOP was measured and compared by iCare rebound tonometer before surgery and 1 day,1 week,2 weeks,1 month,3 months and 6 months after surgery.Results The IOP was(13.31±1.85)mmHg before surgery and that in 1 week after surgery was (33.19±5.59)mmHg,with a significant difference between them (t=94.676,P=0.000).No significant difference was seen among the four groups before operation (P>0.05).The IOP was significantly lower in the C group compared with the A group and B group in postoperative 1 day (P =0.001,0.035),and in the first week after operation,the IOP was significantly lower in the C group than that of the A group (P=0.013).In the second week after operation,the IOP of the B group was considerably lower than that of the A group,and that of the C group was significant reduced in comparison with the B group (P=0.002,0.006).The IOP was lowest in the C group in postoperative 1 month in comparison with the A,B and C groups (P=0.001,0.009,0.026),and lower IOP was found in the C group compared with the A group in 3 months and 6 months after operation (P=0.008,0.011).In addition,the lowing-IOP range was larger in the group compared with the A group and B group in2 weeks and 1 month after operation (2 weeks:P=0.018,0.014;1 month:P=0.024,0.016).No serious complication was found in various groups.Conclusions Both ECP+Phaco+IOL and Trab+Phaco+IOL can reduce IOP effectively and safely.The lowing-IOP effect is better in larger range of cyclophotocoagulation eye during the ECP+ Phaco+IOL surgery.
2.Visual stimulus event related potential and its advances in related studies
Jianing TAN ; Fangliang LUO ; Xinyuan ZHANG ; Jihui LIU
Chinese Journal of Forensic Medicine 2017;32(1):44-47
Event-related potentials (ERP) is some kind of brain potentials that recorded from cranial surface when human cognitive processing an object(pay attention, memorize, thinking, etc). ERP consists of a variety of cognitive function and related components. Including early composition, mismatch negativity (MMN), N2 family, P3 family, and other related components of language processing. These components are closely related to human cognitive function,the research of ERP can lead to a deeper understanding of cognitive function of human brains and has important application value of forensic medicine.
3.Investigation on female sexual status and its influence factors during the second trimester of pregnancy
Wenzhi CAI ; Fangliang ZOU ; Shurong HUANG ; Xiaozhen ZHANG ; Liling CHEN ; Jingjing ZHOU ; Jun ZHANG
Chinese Journal of Practical Nursing 2015;31(16):1209-1211
Objective To survey the female sexual status and its influence factors during the second trimester of pregnancy.Methods The Chinese Version of Female Sexual Function Index (FSFI) and self-administered questionnaires were used to collect the data of 304 women during the second trimester of pregnancy.The investigation results were analyzed.Results Most women reported a decrease in sexual desire(74.7%,227/304),intercourse frequency(90.8%,276/304) and sexual satisfaction(41.1%,125/304).FSFI all dimensions mean scores of these 304 women during the second trimester of pregnancy were less than the critical value,and total FSFI was (20.82±3.74) scores.The female sexual status during the second trimester of pregnancy were affected by age,duration of marriage,education,the way of pregnancy,F=21.974,12.288,3.345,7.748,the differences were statistically significant,P<0.05.Conclusion Pregnant women are in a low level sexual function during the relative safety stage for sexual behavior during the second trimester of pregnancy,so providing some sexual education is necessary to improve couples' sexual health.
4.Application of health belief model education in training of international classification of functioning,disability and health generic set in nurses
Hengying FANG ; Wenzhi CAI ; Xiaozhen ZHANG ; Shan LIU ; Fangliang ZOU ; Jian'an LI ;
Chinese Journal of Practical Nursing 2016;32(8):619-622
Objective To explore the influences of health belief model education on training of international classifiction of functioning,disability and health (ICF) generic set in nurses.Methods Eighty-four nurses from 28 hospitals received a set of education of ICF generic set based on health belief model.Nurses' knowledge and belief of ICF generic set were evaluated before and after education.Results The score of ICF generic set knowledge after education was (5.63±0.75) points,which was higher than that of before education 1 (2) points,and there was significant difference (Z=10.092,P< 0.05).The scores of ICF generic set belief and perceived susceptibility and perceived barriers dimensions were (63.01±7.04),(11.21±1.45),(13.87±2.68) points after education,and (59.62±6.25),(10.11±3.07),(12.68±3.63) points before education,and there were significant differences(t=3.301,2.986,2.414,P< 0.05).Conclusions The heath belief model education can improve the ICF generic set knowledge level of nurses,enhance the nurses' confidence and lower the possible perceived barriers in the application of ICF generic set,and thereby can improve the ICF generic set belief level of nurses.
5.Investigation for Cognition and Practice about ICF Generic Set in Nurses
Hengying FANG ; Wenzhi CAI ; Jianan LI ; Xiaozhen ZHANG ; Shan LIU ; Fangliang ZOU
Chinese Journal of Rehabilitation Theory and Practice 2015;(11):1348-1351
Objective To investigate the knowledge, belief and practice regarding ICF Generic Set in nurses. Methods 107 nurses from 28 secondary- and tertiary-level hospitals were investigated with self-administered questionnaires. Results In the knowledge dimension, 16.3%~39.4% of the nurses were accurate in each item respectively. The nurses got a middle grade in the attitude dimension and all the sub-dimensions. In terms of practice, 39.4%of hospitals and 44.2%of nurses had never used ICF, and the personal usage of ICF correlated with the scores of the knowledge and perceived susceptibility, perceived benefits, perceived barriers and perceived threat of belief. Conclu-sion The nurses are inadequate in the knowledge and attitude of ICF, and the application of ICF need more promotion.
6.Investigation on the allocation status of neonatology nursing human resources in China's economically developed areas
Xiaoning SUN ; Xinfen XU ; Jun ZHANG ; Fangliang ZOU ; Shurong HUANG ; Wenzhi CAI
Chinese Journal of Practical Nursing 2014;30(17):26-30
Objective To study the status quo of nursing human resource configuration and structure of neonatology department in China's economically developed areas.Methods Using judgment sampling and multi-stage stratified sampling,investigations were conducted by the self-designed questionnaire in letter in 2012.Results In 2012,both the bed nurse ratio(1:0.79) and doctor nurse ratio (1: 1.22) met the Health Ministry's standards (1:0.58-0.61 and 1: 2) respectively.Age distribution of neonatology nursing staff was from 25 to 34 years old (55%).The distribution of wordng experience was average.Nurses with junior college degree as the main body took up 48%,with primary title as the main body 66%,and the appointment system accounted for 42%.The nursing personnel with young ages,senior skilled,higher education degree,and advanced titles were concentrated in Grade Ⅲ-A hospitals and public hospitals of women and children.In terms of distribution equity,two Gini coefficients of geographical and population distribution were both less than 0.35 and near zero,which indicated relatively perfect equity.Conclusions The stock and per capita of neonatology nursing human resources in China's economically developed areas were insufficient in the long run and showed imbalanced allocation among hospitals with different levels.The allocation structure failed to meet the needs of nursing disciplinary development.
7.Molecular Characterization of a Highly Pathogenetic Porcine Reproductive and Respiratory Syndrome Virus Variant in Hubei, China
Yi HUANG ; Bing ZHANG ; Zhenfang FU ; Simon RAYNER ; Fangliang ZHENG ; Wangwang LIANG ; Keli YANG ; Diping XU ; Hanzhong WANG
Virologica Sinica 2009;24(1):9-18
Porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized as one of the most important pathogens of pigs throughout the world. In 2006, more than 10 provinces of China have experienced an epizootic outbreak of pig diseases characterized by high fever, reddened skin and high morbidity and mortality. From June 2006 to April 2007, we have investigated some clinical samples in Hubei province by RT-PCR and cloned several major genes, N, GP5 and NSP2 gene, shown in this study. Phylogenetic analysis of these genes revealed that the highly pathogenic PRRSV variant, ZB, was responsible for 2006 emergent outbreak of pig disease in Hubei province similar with those variants isolated from other provinces in China in 2006, and belongs to the NA-type PRRSV. In the PRRSV variants, the N and GP5 shear about 90% identity with prototypic ATCC VR-2332 and some typical NA-type Chinese isolates, except the 2850bp NSP2 gene (only shares 65% identity with ATCC VR-2332). But they all shear more than and 97% identity with other highly pathogenetic Chinese PRRSV strains. Additionally, there are extensive amino acid (aa) mutations in the GP5 protein and 2 deletions in the Nsp2 protein when compared with the previous isolates. Most of the variants found in 2006 epizootic outbreak of pig diseases in China were the farthest variants from the typical NA-type PRRSV in phylogenetic distance, and these diversities may be responsible for the differences in the pathogenicity observed between these variants and original Chinese PRRSV strains.
8.Reform of public hospitals performance evaluation system in integrating target evaluation and focused evalua-tion
Yong YAN ; Yiping LYU ; Jinbao ZHANG ; Hui LI ; Fangliang LI ; Dingguo NONG ; Cunliang WANG ; Jing LIU ; Ke LI
Chinese Journal of Hospital Administration 2015;(7):492-499
Building a better performance evaluation system for public hospitals is key to the ongoing health reform. To this end, Beijing Municipal Administration of Hospitals reformed the performance evaluation system of public hospitals in Beijing based on its experiences during 2012 to 2014. This reform integrates the target tasks,day-to-day performance,personalized performance,Party and people management performance,and mandatory plan performance as one evaluation integrity,forming a new public hospitals’performance evaluation system of multi-dimension and multi-level.This approach can effectively integrate diversified performance management objectives and overcome key difficulties in performance management,assisting further promotion of the approach,facilitating government objectives in managing the medical sector,promoting healthy development of hospitals,and exploring how to deepen the public hospital reform in terms of separating ownership from operations.
9.Practice and insight of building a performance evaluation system of public hospitals in Beij ing
Guosheng FENG ; Jinbao ZHANG ; Hui LI ; Fangliang LI ; Yong YAN ; Dingguo NONG ; Cunliang WANG ; Jing LIU ; Ke LI
Chinese Journal of Hospital Administration 2015;(7):487-491
The role of public hospital performance evaluation has become a roadblock for the current reform of public hospitals.By summarizing the performance evaluation of Beijing municipal hospitals in recent three years,the authors systematically introduced the practice of Beijing Municipal Administration of Hospitals in establishing a public hospital performance evaluation mechanism.In addition,the paper introduced the achievements of the Administration in the evaluation methods of public hospital evaluation,governmental responsibilities in hospital governance,guidance of hospitals’orderly development,and positive interactions between the government and hospitals.This way the paper provided useful references for guiding the hospitals back to public service nature,positive interactions, refined management of hospitals and better performance management.
10.Effects of Loading-dose of Rosuvastatin before PCI on Reperfusion Arrhythmias in Patients with Acute Non-ST-segment Elevation Myocardial Infarction
Hongsong LI ; Xiangdong XU ; Guolin WU ; Fangliang ZHANG ; Li ZHANG ; Xia CHEN ; Yingmin CHEN
China Pharmacy 2017;28(36):5064-5067
OBJECTIVE:To investigate the effects of loading-dose rosuvastain before early percutaneous coronary intervention (PCI) on reperfusion arrhythmias in patients with acute non-ST-segment elevation myocardial infarction (NSTEMI).METHODS:A total of 136 patients with NSTEMI were randomly divided into loading-dose group (68 cases) and control group (68 cases).Both groups who were not given anti-platelet drugs were given loading-dose of Aspirin enteric-coated tablets 300 mg+Clopidogrel sulfate tablets 600 mg immediately after admission.The patients who were given aspirin regularly were given loading-dose of Clopidogrel sulfate tablets 600 mg only once after admission.The patients who were given clopidogrel regularly were given loading-dose of Aspirin enteric-coated tablets 300 mg only once.Those received PCI 12-24 h after medication.After PCI,they took Aspirin enteric-coated tablets 100 mg for life+Clopidogrel bisulfate tablets 75 mg at least 12 months.Loading-dose group was given loading-dose of Rosuvastatin calcium tablets 20 mg orally,12 h before surgery.All patients began to take Rosuvastatin calcium tablets 10 mg,once a day,since the night after the operation.Coronary angiography and the occurrence of reperfusion arrhythmia were observed in 2 groups.The levels of CK-MB and cTnT,major adverse cardiovascular events (MACE) were observed before and after surgery.RESULTS:There was no statistical significance in the number of diseased vessels,culprit vessels,the degree of culprit vessels stenosis or the incidence of MACE between 2 groups (P> 0.05).The incidence of reperfusion arrhythmia in loading-dose group was significantly lower than control group,with statistical significance (P<0.01).There was no statistical significance in the degree of culprit vessels stenosis between 2 groups (P>0.05).Before surgery,there was no statistical significance in the levels of CK-MB or cTnT between 2 groups (P>0.05).After surgery,the levels of CK-MB and cTnT in 2 groups were significantly higher than before surgery,but the loading-dose group was significantly lower than the control group,with statistical significance (P<0.01).CONCLUSIONS:Preoperative loading-dose of rosuvastatin before PCI can reduce the incidence of reperfusion arrhythmias in NSTEMI patients.