In order to promote the informatization construction of medical education and further enhance teachers' cognition of informatization, Zunyi Medical University actively promotes digital teaching tools, innovates education and teaching management, and promotes the deep integration of information technology and education. For this reason, the systematic anatomy of clinical specialty was selected to establish the network course system, and the network course of systematic anatomy was created by using video software such as Camtasia studio 9, Adobe After Effects CS6 and format factory, and the exclusive network course system of systematic anatomy was created on the superstar learning platform to explore the online teaching mode. Through the evaluation of online and offline teaching, we know that the online teaching reform has achieved the expected teaching effect, stimulated the students' autonomy in learning, and realized the teaching requirements of systematic anatomy. However, there are still many problems, such as how to better integrate online and offline, which needs further exploration.