Objective To observe the clinical effect of blood-pricking therapy combined with electroacupuncture in the treatment of migraine. Methods 70 patients with migraine who were admitted to Chengbei Branch of Hangzhou First People's Hospital from October 2015 to October 2016 were randomly divided into two groups: blood-pricking therapy combined with electroacupuncture group (observation group) and oral western medicine control group (western medicine group) respectively, with 35 cases in each group. The observation group was given pricking for bloodletting combined with electroacupuncture. The oral Western medicine control group was orally given ergotamine caffeine tablets and flunarizine for treatment, with the course of treatment of 12 days. Visual analogue scores(VASscores) 30 minutes after the end of the first treatment and headache scores at the end of the treatment period were observed. The difference of the efficacy of the two treatment methods was compared. Results The decrease value of VASscore in the observation group 30 minutes after the end of treatment was better than that in western medicine group(P＜0. 05). Before and after treatment, the decrease value of the headache scores and the total effective rate in the observation group were better than those in the western medicine group(P＜0. 05). The adverse reaction rate in the observation group was significantly lower than that in the western medicine group(P＜0. 05). Conclusion The combination of blood-pricking therapy and electroacupuncture and oral administration of western medicine both have a good immediate analgesic effect on migraine. However, the immediate analgesic effect and the short-term efficacy of blood pricking combined with electroacupuncture in the treatment of migraine are significantly better than those of oral administration of western medicine, and the safety is high, which is worthy of promotion.

Objective:To investigate the evaluation value of one-stop whole-brain dynamic volume CT angiography and CT perfusion imaging (CTA-CTP) in the cynomolgus monkeys models of middle cerebral artery occlusion (MCAO).Methods:Ten adult cynomolgus monkeys were selected and examined by head and neck CTA-CTP and craniocerebral MRI to rule out craniocerebral space-occupying lesions or cerebrovascular malformation. Under guidance of digital substraction angiography (DSA), the right femoral artery was dissected and monkey autologous thrombosis was injected into the right middle cerebral artery (MCA) through microcatheter to prepare MCAO models. Whole brain DSA was performed intraoperatively to observe whether the model was successfully prepared, and head and neck CTA-CTP was performed 24 h and 7 d after modeling to determine the locations and brain blood flow changes of ischemic lesions. The monkeys were sacrificed 8 d after modeling, and the brain tissues were stained with 2,3,5-triphenyltetrazolium chloride (TTC).Results:Among the 10 cynomolgus monkeys, one was excluded because of preoperative cerebrovascular malformation, and one died of cerebral hernia caused by cerebral hemorrhage during the experiment. The remaining 8 MCAO models were successfully prepared. Intraoperative DSA orthography showed unclear M1 segment and distal branch of MCA. Brain CT scan 24 h and 7 d after modeling showed obvious cerebral ischemic lesions in the right MCA blood supply area, and the infarct extent 7 d after surgery was more obvious than that 24 h after surgery. CTA examination showed obvious blood flow interruption imaging in the in M1 segment of MCA on the right side, the distal vessels were not clearly displayed and the distal branches of the infarct side 7 d after surgery were obvious decreased as compared with those 24 h after surgery. CTP scan showed that the cerebral blood volume of the right cerebrum was obviously reduced as compared with that of the left cerebrum, which was consistent with the blood supply area of MCA; and the infarct cores and penumbra areas 7 d after surgery were obvious increased as compared with those 24 h after surgery. TTC staining showed that the ischemic lesions of the brain tissue on the slices were gray and involved multiple layers, and the range was roughly consistent with the infarction sites shown by DSA and CT imaging.Conclusion:One-stop whole brain dynamic volume CTA-CTP has good evaluation value in imaging findings in MCAO animal models.