1.Recent advance in predictors and risk prediction models for conversion from mild cognitive impairment to Alzheimer's disease
Yanru CHEN ; Hongxia LU ; Xinyu WANG ; Wenli SU ; Ya'nan HUANG ; Xiaoli CHEN ; Fanghong YAN ; Guode WU ; Lin HAN ; Yuxia MA
Chinese Journal of Neuromedicine 2022;21(6):629-635
Alzheimer's disease (AD) is the most common form of dementia in the elderly, and there is no specific treatment to stop or reverse its progression. Mild cognitive impairment (MCI) is an important entry point for early diagnosis and prevention of AD. More and more studies have explored the risk factors and biomarkers for conversion from MCI to AD, and a series of risk prediction models have been established. This article analyzes and summarizes the different predictors and risk prediction models so as to provide basis for early identifying the high-risk group of AD, managing the controllable risk factors, and providing references for the selection and improvement of these models.
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