Objective:To compare the efficacy and complication in clinical application about the indwelling central venous transfusion port and peripheral venipuncture central vein indwelling catheter.Methods: 80 cases with indwelling central vein transfusion port were arranged to observation group and 80 cases with peripheral venipuncture central vein indwelling catheter were arranged to control group. All of patients were detected for blood routine, blood coagulation time and chest X-ray fluoroscopy routine examination before operation. And to take venipuncture by right subclavicle of patient skin under X-ray fluoroscopy guided, and then indwell catheter. To compare the clinical effect for the two kinds of indwelling catheter method.Results:In observation group, the successful rate was 97.5% (78/80), the average operation time was (51.23±10.21) min; while in control, the successful rate was 78.8% (63/80), the average operation time was (67.42±11.03)min, there were statistical significant difference in successful rate (x2=13.44,P<0.05) and average operation time (t=9.63,P<0.05) between observation and control group. In observation group, the rate of complications occurred was 13.75% (11/80), which was significant lower than 32.5% of control (26/80)(x2=7.91,P<0.05).Conclusion: It is safe and reliable to use the dwelling central venous transfusion port, and the complication of some patients mainly related with nursing skill of paramedic and the proficiency degree of pillbox puncture and using skill in this operation.

BACKGROUND:Laryngeal cartilage defect has a higher incidence, mainly presenting with pain, sweling, and dysfunction after onset. Currently, surgical treatment is the most used in clinical treatment of laryngeal cartilage defect. Although conventional materials can effectively improve symptoms, there is a poor long-term efficacy. In recent years, there are many clinical studies on cartilage tissue engineering, but less about the actual use in the otorhinolaryngology department.
OBJECTIVE:To investigate the effect of polyhydroxyalkanoate polymer carrying chondrocytes on the repair of alogeneic laryngeal cartilage defects.
METHODS:Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHH) served as the extracelular matrix. Tissue engineering technology was used to prepare cel-material composite. Primary tissue-engineered cartilage tissue was transplanted directly into rabbit thyroid cartilage defect (experimental group A), or implanted into a more mature tissue-engineered cartilage for the repair of thyroid cartilage defect (experimental group B). In the experiment, PHBHH group and simple chondrocyte group were set as controls. Repairing effects on thyroid cartilage defect were evaluated through gross and histological observation.
RESULTS AND CONCLUSION:Chondrocytes in the primary tissue-engineered cartilage tissues were beaded under scanning electron microscope, and after 4 weeks of culture, a large amount of jely-shaped substrates were visible. Findings from electron microscope observation showed that the cels were distributed on the surface of composite material and cavernous voids, displaying a plurality of smal round projections. Surgical treatment was successful in al the rabbits, and there was no dyspnea and eating difficulties after surgery. One rabbit appeared to have brief wheezing in the experimental group A, two rabbits died of diarrhea in the experimental B group at 2 weeks after surgery. PHBHH composite carrying chondrocytes had certain hardness. At 4 weeks after subcutaneous implantation, mature cels were shaped as white sheets, and the material had elasticity. After 4 and 8 weeks, the space between repair zone and original cartilage tissue was smooth and plain, but the repair zone was colored yelow. In the simple PHBHH and chondrocyte groups, the repair zones were both depressed, only the connective tissues could be seen. Rabbits in the two experimental groups showed less adverse reactions compared with the two control groups (P < 0.05). These findings indicate that PHBHH composite carrying chondrocytes has better effects to repair alogeneic laryngeal cartilage defects.

It was confirmed that acetylcholine signaling pathway and dopamine signaling pathway play critical roles in refractive development.Many evidences have supported that acetylcholine and its receptor antagonists were closely related to the formation of experimental myopia.Retinal dopamine signaling could exert a significant influence on refractive development,and its upregulation induced by light comprises an important component of the retinal clock network;meanwhile,the retinal dopamine signaling could also participate in the regulation of retinal circadian rhythms.The role of intrinsic retinal circadian rhythms in the developing process of myopia is gaining increasing attention.Moreover,it was also found that both acetylcholine and dopamine signaling pathways influence the development of myopia.Therefore,the present paper summarizes the two signaling pathways in the mechanisms of regulating myopia process,which provides an insight into the pathogenesis of myopia and clinical ideas for the effective prevention and treatment of myopia.

Objective To design a pulse wave measurement system based on ZigBee wireless technology. Methods CC2430 controlled by the pulse sensor unit will be collected in pulsatile signal to human superficial artery through analog circuit preprocessing, which could be transformed into digital signal in digital model, and then can be impressed and displayed by control unit to deal with and display, at the same time, data in ZigBee wireless communication data unit is sent to the host computer and these data would be retrieval and playback of medical workers. Results The experiments show that the system is able to acquire the pulse wave of the human body in real-time, at the same time, through the ZigBee wireless network, it can be real-time, secure and reliable communications. Conclusion It is applicable to a wide range of health movement monitoring, monitoring of mobile hospitals and other areas.

Objective To design a wearable monitoring system for community medicine.Methods The wearable monitoring system was composed of wearable physiological signal detection component,wireless data transmission component and the central signal processing component,with new technologies adopted such as wearable detection technology and Zigbee wireless communication technology.Results The acquired signals were uploaded to the community medical monitoring terminal through Zigbee wireless network for signal processing,display and pre-diagnosis.The function of emergency alarm was also available.Conclusion The wearable monitoring system,with realtime signal acquisition and Zigbee wireless communication,can be applied to mobile monitoring during exercise or in hospital.

The use and management of medical implanting material is always the key point of the hospital material management. Questions existing in hospital management were investigated along with some suggestions in further management in the system and the process.

Probiotics as intestinal flora regulators are increasingly applied in clinical practice;however,the administration of probiotics in immunocompromised individuals is rarely reported.This article is aimed to review the benefits and risks of probiotics in immunocompromised individuals,such as HIV-infected individuals and patients with malignant tumors.The research evidence shows that probiotics can reduce the occurrence of different types of diarrhea,regulate the intestinal immune status and decrease the incidence of complications in immunocompromised patients.Randomized controlled clinical trials have shown that the risk of adverse events is not significantly increased in immunocompromised patients compared to those with intact immune status and the probiotics-related infections are only presented in case reports.

Objective To analyze the clinical characteristics and prognostic factors of endometrial carcinoma in senile women, explore the optimized therapeutic modality. Method The clinic pathological characteristics and survival outcome of 268 patients of endometrial carcinoma in senile women were reviewed retrospectively, and prognostic factors affected the survival of endometrial carcinoma were evaluated. Results According to univariate analysis, therapeutic modality, surgical-pathological classification and pathological grade were closely correlated with prognosis of endometrial carcinoma in senile women(P < 0.01 ). According to COX multivariate analysis,surgical-pathological and pathological grade were independent prognostic associated-factor (P = 0.002,0.000). Conclusions There are closely correlations between prognosis and surgical-pathological classification,therapeutic modality and pathological grade,surgical-pathological classification and pathological grade are independent prognostic associated-factor. The therapy on endometrial carcinoma in senile women should connect with high risk factors and adopt integrating and individual therapeutic modality.

Objective　To discuss the possibility of ultrasonic superficial spray anesthesia applied to bronchoscopy in children with intratracheal foreign bodies. Methods　50 cases with intratracheal foreign body were divided into two groups: surface anesthesia group (S group) and intravenous anesthesia group (Ⅰ group). 2% Lidocain by ultrasonic spraying inhalation for 8～10 min and r-OH 80 mg*kg-1+Ketamine 1 mg.kg-1 intravenous injection were adminstered respectively. Results　In S group perioperative the MAP and HR were stable， the complications were fewer and the SpO2 was >95%，the awaking time was shorter (70.1±15.3) min after operation；In I group the MAP and HR were descendent (P<0.05)， the complications were more and the SpO2 was <95% (P<0.05)， the awaking time was longer(P<0.01). Conclusion　The surface anesthesia is effective.The MAP and HR are stable，the complications are fewer and the awaking time is shorter.

Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) includes granulomatosis with polyangiitis,microscopic polyangiitis,eosinophilic granulomatosis with polyangiitis,which are known for this name because the common involvement of ANCA in the serum.New revise have been made in the Chapel Hill consensus conference 2012 about the nomenclature and definition of vasculitides,including the AAV.AAV can be misdiagnosed and delay diagnosed very easily for the variety and lack of specificity of clinical manifestations,and a early diagnosis and timely treatment is the key for a better prognosis.