Sleep disorders are main clinical symptoms in perimenopausal women. The symptoms are difficulty in initiating or maintaining sleep, early morning awakening and so on. These sleep problems had made serious im-pacts on the quality of women's life during menopausal periods. Menopausal sleep disorders can be caused by changes of serum estrogen levels, vasomotor symptoms, mood disorders and patient's state of disease. This paper presented an overview of inducing factors and current situation of menopausal disorder treatment.

Objective To study the clinical characteristics, diagnosis and treatment of childhood visceral leishmaniasis. Methods A retrospective analysis of 46 cases of children with visceral leishmaniasis was performed, epidemiological and clinical characteristics, laboratory and special inspection, diagnosis and treatment were analyzed. Results All 46 cases (27 males and 19 females) were mostly from the epidemic area and sporadically happened in spring, autumn, and winter, lacking of specific symptoms. Clinical features include long-term and repeated fever, anemia, abdominal distention and respiratory infection, the most common feature is fever accompanied with liver, spleen and lymph node enlargement. Laboratory tests were mainly found with anemia, pancytopenia in peripheral blood , damaged liver function, and elevated CRP. Bone marrow cytology smear found duchenne body- in 26 cases, the positive rate was 61.36%. Visceral leishmaniasis serological antibody were positive in 28 patients, positive rate was 96.29% (28/30). 30 cases were treated with meglumine antimoniate, 26 cases were cured, 3 cases died, and 1 case were not cured and discharged from the hospital. The treatment effective rate was 86.67%. Conclusions Childhood visceral leishmaniasis is still popular in recent years lacking of characteristic clinical symptom. Therefore, for the patients in the epidemic area who presented with long-term fever, anemia, or pancytopenia in peripheral blood, hepatosplenomegaly (especially the splenomegaly), and liver function damage, bone marrow puncture, visceral leishmaniasis antibodies and/or RK39 dipstick test and relevant auxiliary examination should be considered for early diagnosis and treatment, thus to reduce the complications and to improve the cure rate.

Medical nutrition therapy (MNT)is the basic and long-term treatment of diabetes patients. At present,the dietary structure of type 2 diabetes mellitus(T2DM)patients in China has yet to be further improved. This article focused on the effect,dietary structure,food selection and guarantee of compliance of MNT in T2DM.We recommended that the dietary pattern should be designed based on the traditional dietary habits around the country,combined with people living and working reality. The rational utilization of network platform can improve the efficiency and compliance of nutrition education.

Ginsenoside Rg1 ( Rg1 ) is a monomer isolated from ginseng, which has a variety of pharmacological activities. Rg1 can obviously regulate hematopoietic stem cells, mesenchymal stem cells, neural stem cells and endothelial progenitor cells proliferation, differentiation, aging, secretion and so on by mul-tiple mechanisms. Rg1 has important therapeutic effects on the reparation of tissues, organs damage and aging. This review de-scribes the current knowledge on the effects of Rg1 on the char-acteristics and functions of adult stem cells.

thoracic, but the density of SKLI in the enlargement of the cervical segments is much higher than any other cervical segments. No SKLI was found in the ventral horn. It was also discussed that substance k may act as a neurotransmitter in nervous system.

OBJECTIVE To study the classification and distribution of the ?-lactamases produced by Escherichia coli in diabetic patients.METHODS To detect the ?-lactamases produced by E.coli in diabetic patients with a multi-disk synergy test.RESULTS Forty-nine strains of 60 strains in our study produced the ?-lactamases with total positive rate of 81.67%,From them 5 strains were producing penicillinases,17 strains producing BSBLs(28.33%),and 27 strains were producing ESBLs(45.00%),no carbapenem-hydrolyzing ?-lactamases were detected.In 27 strains producing ESBLs,the sensitivities to the ceftazidime,aztreonam and cefotaxime were similar.CONCLUSIONS The types of ?-lactamases produced by E.coli in diabetic patients are mainly BSBLs and ESBLs,without carbapenem-hydrolyzing ?-lactamases;the sensitivities to the ceftazidime,aztreonam and cefotaxime are similar.

Objective To reproduce the human endometriosis (EMS) in nude mouse, and to asssess the effects of endostatin in this model. Methods Endometrium tissue was collected from four women undergoing hysterectomy for EMS, and it was transplanted into 30 female BALB/c nude mice by subcutaneous injection (n=20) and intraperitoneal injection (n=10) respectively. The development of endometriotic lesions in nude mice was observed three times every week. Two weeks later, the successful rate in the two groups was estimated. The model mice in subcutaneous injection group were then randomized into treatment group (n=8) and control group (n=7). The mice in treatment group were injected with human endostatin (2mg?kg -1 ?d -1 ), while the mice in control group received an equivalent volume of PBS. All mice were sacrificed 14 days after treatment. Immunohistochemistry was used to determine the expression of vascular endothelial growth factor (VEGF). Results Transplantation was successful in 7 nude mice in abdominal implantation group and 15 nude mice in subcutaneous injection group. The success rate was 75% in subcutaneous injection group and 70% in abdominal implantation group, no significant difference was found between two groups. The level of VEGF in the nude mice treated with endostatin was significantly lower than that in the control group (P

Objective To study the effect of IL-6 and IL-8 on the MMP-9 secretion of endometrial stromal cells in women with endometriosis to explore the function of IL-6 and IL-8 in the adherence and planting process of ectopic endometrium. Methods The endometrial stromal cells were cultured in DMEM/F12 medium containing different concentrations of IL-6 or IL-8 for 24 hours, then the media were collected to measure the levels of MMP-9 by ELISA. Results The levels of MMP-9 in control stromal cells cultured with high concentration of IL-6 were significantly higher than those without IL-6 (P

OBJECTIVE:To study the mechanisms of GJKL(Gujikang liniment) in treatment of soft tissue injury METHO_DS:The effects of intraperitoneal injection of acetic acid solution on capillary permeability were observed;An animal model of soft tissue injury was established by striking The effects of GJKL on hemorheological parameters were observed RESULTS:GJKL markedly inhibited capillary permeability and decreased hemorheological parameters CONCLUSION:GJKL takes therapeutic effects on soft tissue injury through inhibiting the increased capillary permeability and reducing the hemorheological parameters

Objective To study the psychological intervention of patients with schizophrenia using olanzapine treatment. Methods A total of 336 patients with schizophrenia from February 2015 to October 2016 were selected as the study subjects,randomly divided into the control group and the experimental group,each with 168 patients.Control group patients with olanzapine treatment,on the basis of the experimental group patients given psychological intervention,pay attention to the psychological state of the patients,strengthen the communication and exchanges with the patient,the treatment of patients with increased confidence and treatment compliance.The therapeutic effect of the experimental group and the control group was compared. Results After the corresponding treatment,7 patients in the experimental group showed a nursing dispute,which was 4.17％. In the control group, 46 patients had nursing disputes, accounting for 27.38％.However,the probability of nursing dispute in the experimental group was significantly lower than that in the control group,with statistical difference(P<0.05).The effective number of patients in the experimental group was 168.The effective number of patients in the control group was 120,and the proportion was 71.43％,with statistical difference(P<0.05). Control patients satisfaction with nursing cases for 130 cases,38 cases of patients are not satisfied,70 patients were generally satisfied with,is satisfied with 60 patients,patient satisfaction and nursing satisfaction rate of 77.38％ significantly lower than that of the experimental group(100％),with statistical difference(P<0.05). Conclusion Psychological intervention with olanzapine in the treatment of refractory schizophrenia better clinical effect, can significantly improve the treatment efficiency,further promotion of clinical significance.