Adolescent ; Adolescent Development ; Body Mass Index ; Humans ; Obesity ; Puberty

Objective To determine the relationship between maternal negative major life events during the first trimester and incidence of congenital heart diseases(CHD) in their offspring.Methods The 4-2-1 medical information was referred and screen CHD children who were confirmed by Municipal hospitals over.A 1:2 case-control study was carried out with face-to-face structured interviews and telephone interviews to investigate parents of 116 children with CHD and 232 healthy matched children,including the parents′ demographic variables(such as whether the working environment exposure to toxic and hazardous substances 1 year before pregnancy,et al),mother′s experience of previous adverse pregnancy,duration of pregnancy condition(such as maternal negative major life events during the first trimester,the history of catching a cold or fever during the first trimester.The possible risk factors were analyzed by simple factors Logistic regression methods.Then,diagnosing the colinearity among these suspicious risk factors,and rejecting it if necessary.Finally,multiple factors conditional Logistic stepwise regression was used to filter once more.Results The results revealed that maternal negative major life events and taking medicine during the first trimester,mother′s experience of previous adverse pregnancy were related to the occurrence of CHD in the offspring.Moreover,maternal negative major life events during the first trimester play the most important role(OR=1.810).Conclusions Strengthening mothers′ mental health and controlling or reducing maternal negative major life events during the first trimester may be effective in reducing the risk of CHD.

Adolescent ; Attention ; physiology ; Female ; Humans ; Male ; Obesity ; physiopathology ; psychology ; Weight Loss ; physiology

Brain ; physiology ; Child ; Child Behavior ; physiology ; Child Development ; physiology ; Humans ; Infant ; Motor Activity ; physiology ; Motor Skills Disorders ; diagnosis

Adolescent ; Health Promotion ; Humans

Advanced in medical and surgical management have led to reduce mortality in children with congenital heart disease(CHD).However,more recent and ongoing research had been focused on neurodevelopmental outcome.With the improved survival in children follo-wing surgery for cardiac malformations,increased emphasis had being placed on neurological sequelae,especially on cognitive function.Car-diac surgery couldn't correct cognitive disorder,more and more findings suggested that the cognitive disorder of CHD might be the result of utero injury.J Appl Clin Pediatr,2009,24(1):61-64

Humans ; Organophosphorus Compounds ; analysis ; pharmacokinetics

Objective To explore whether obese adolescents had neurochemical abnormalities in frontal lobe and hippocampus.Methods Anthropometric indicators were measured in all participants.Proton magnetic resonance spectroscopy(1H-MRS)were performed in 9 obese adolescents and 9 non-obese children as controls.Spectral peaks of N-acetylaspartate(NAA),creatine(Cr),choline(Cho)of 2 cortexes were measured and their ratios were computed and compared.Results Values of NAA and Cho in frontal lobe in obese group were significantly lo-wer than those of controls.There was no significant difference of Cr,NAA/Cr,Cho/Cr in frontal lobe and hippocampus between 2 groups.Conclusion The reduced NAA and Cho on 1H-MRS suggests that amount of neural nerve and myelination of white matter may be harmed in frontal lobe of obese adolescents.

OBJECTIVETo investigate the prevalence of suicide ideation, suicide plan and suicide attempts in middle school students in Hefei, Anhui province, and to determine correlated factors.

METHODSThe investigation was administered to 3127 middle school students from 7 schools in Hefei, Anhui province. All participants completed an anonymous questionnaire concerning their experiences with specific suicide behaviors during the 12 months preceding the survey. School life satisfaction, coping style were evaluated by School Life Satisfaction Rating Questionnaire for Adolescent and Trait Coping Style Questionnaire, respectively. Chi-squared test was used to assess gender difference of suicide ideation, suicide plan and suicide attempt. Logistic regression analyses were applied to identify factors associated with adolescent suicide behaviors.

RESULTSOf the subjects investigated, 28.0 percent had thought seriously about attempting suicide, 11.9 percent had made a specific plan to attempt suicide, and 4.0 percent actually had attempted suicide. It was found that main risk factors among three specific suicide behaviors were related to negative coping style. School life satisfaction was protecting factor of suicide ideation and suicide attempt.

CONCLUSIONIt was suggested that focusing on these psychosocial factors would help enhance suicide assessment and prevention efforts with adolescents.

Adaptation, Psychological ; Adolescent ; Adolescent Behavior ; psychology ; Chi-Square Distribution ; China ; epidemiology ; Female ; Humans ; Logistic Models ; Male ; Personal Satisfaction ; Prevalence ; Risk Factors ; Schools ; Social Environment ; Students ; psychology ; statistics & numerical data ; Suicide ; statistics & numerical data ; Suicide, Attempted ; statistics & numerical data ; Surveys and Questionnaires