Objective:To investigate the effect of sandplay therapy on repeated dream.Methods:A patient who had been puzzled by repeated dream for years was treated by sandplay therapy.Results:The patient's repeated dream changed greatly,and made it have transformations as follows.(1)Frequency.Dream appeared less and less,even disappeared;(2)Emotion.It was less negative,and the intensity alleviated by degrees;(3)Develop direction.It was more positive;(4)The develop pace was more rapid.Intervention expedited the step and there were marked seedtime;(5)Repeated elements in dream were more positive.Conclusion:Repeated dream will disappear when emotion has been released and the problem has been settled.Sandplay therapy may be effective in the intervention on repeated dream.

The education and development of the handicapped children has been regarded as part of the community-based rehabilitation now. Our purpose is to give those handicapped children opportunities to be educated, take part in social life, and come back to the society. The author summarized and analyzed some successful methods about community-based rehabilitation in western poverty region of China by international project, and suggest that great efforts has to be taken to improve the inclusive education of handicapped children by community-based rehabilitation.

Objective To explore the protective effect of Ligustrazine on pulmonary fibrosis caused by hyperoxia in neonatal rats.Met-hods Eighty Sprague-Dawley(SD)clean neonatal rats,which were less than 12 hours old,were enrolled in this study.The neonatal rats were randomly divided into 4 groups:air-exposed control group(group A);air-exposed plus Ligustrazine-treated group(group B);hype-roxia-exposed control group(group C);hyperoxia-exposed plus Ligustrazine-treated group(group D).The neonatal rats of group B and group D were intraperitoneally injected with Ligustrazine[30 mg/(kg?d)] in solution of normal saline(NS),group A and group C were intraperitoneally given the same dose of NS.On 14th day,10 rats of each group were randomly chosen and then killed,the pulmonary pathological changes were observed by HE staining under light microscope.The area percentages of collagen fibers were measured by Masson staining and imaging analysis.The degree of pulmonary fibrosis was evaluated by the area percentages of collagen fibers and hydroxyproline content.The results were analyzed by SPSS 13.0 software.Results On the 14th day of the exposure,the histopathologic examination demonstrated broadened lung interstitium and reduced alveolar quantity and lung fibrosis were developed in group C;Ligustrazine treatment obviously alle-viated the changes of lung histomorphology.The newborn rats in group C had lower body weight compared that of with group A,B(Pa0.05).Conclusion Early use of Ligustrazine can decrease the severity of the pulmonary fibrosis of neonatal rats exposed to hyperoxia.

Objective To investigate the effect of intra-dialytic exercises on micro-inflammatory state in maintenance hemodialysis (MHD) patients. Methods Sixty clinically stable MHD patients from the Hemodialysis Center were enrolled in the study . The patients were divided into exercise group and control group with 27 cases in each group by using the random digit number table. The patients in the exercise group underwent a 6-month intra-dialytic exercise, in which the patients conducted physical exercises supinely on a cycle ergometer each for 50 minutes, 3 times a week. The patients in the control group were treated without any exercise intervention. Serum interleukin-6(IL-6), C-reactive protein(CRP) and tumor necrosis factor-α(TNF-α) were determined after the study for 0 and 6 months. Results After the 6-month intradialytic exercise program, serum IL-6, CRP and TNF-α were all decreased in the exercise group (P < 0.05). These indices were unchanged in the control group (P > 0.05). Conclusion The intra-dialytic exercises can alleviate micro-inflamatory state in maintenance hemodialysis patients.

Objective To study the expressions of matrix metalloproteinase-2(MMP-2)and vascular endothelial growth factor (VEGF)in laryngeal carcinoma and their clinicopathological significance.Methods The immuno-histochemical technique was used to detect the expression staining results of MMP-2 and VEGF in 54 cases of laryngeal carcinoma,23 cases of polyps of vocal cord and 1 5 cases of normal laryngeal mucous tissues verified by clinicopathology under the automatic image analyzer.Results The ex-pression rates of MMP-2 and VEGF were 72.22%(39/54)and 70.37%(38/54)in the laryngeal carcinoma tissue,which were sig-nificantly higher than 47.83% and 39.13% in polyps of vocal cord and 40.00% and 46.67% in the normal laryngeal tissues respec-tively,the differences between them had statistical significance(P<0.05).The expressions of MMP-2 and VEGF had certain corre-lation with the clinical stage,lymph node metastasis and.infiltration depth of laryngeal carcinoma.Conclusion MMP-2 and VEGF may jointly participate in the process of infiltration and metastasis in laryngeal and have certain relation with the tumorous invasive growth.

Objective To understand Parkinson disease (PD) medication compliance, and analyze its main influencing factors. Methods The questionnaire method was adopted to survey 130 cases of Parkinson disease patients general information, disease, drug, psychological status, social support and so on. Results The two average score of Parkinson patients medication compliance were (2.36 ± 1.16) points and (9.96 ± 2.60) points. Its influencing factors had personal monthly income, medication concept, PD drug adverse reaction,social support, mental state and anxiety disorder. Conclusions Parkinson patients medication compliance behavior overall is good, but these patients who can be in strict accordance with the doctor′s advice has very few. And the influencing factors are in the majority. According to the influencing factors of medication adherence, medical staff should implement targeted medication guide, in order to improve the medication complianceand their quality of life.

10 cm respectively from the tumor),the metastatic rate of lymph nodes was 34.7%,2.5% and 1.7%,respectively.The metastatic rate of LN in right colon was significantly higher than that in left colon(52.0% vs 33.8%,P

Objective: To study the relativity between the heating degree and color value of Chinese materia medica pieces. Methods: The effects of heating temperature and time on the color value of Gardeniae Fructus and Crataegi Fructus were investigated by spectrophotometric technique. Results: The color value curve of Gardeniae Fructus after processing under the mid-and high-heating showed the better rules that the stationary phase of L* and δE* appeared in 7 min and stationary phase of a* and b* appeared in 4 min. However, the color value curve of Crataegi Fructus showed the stationary phase of L*, a*, b*, and δE* appeared in 5 min after low-heating process. After the mid-heating process, the stationary phase of L* and δE* appeared in 6 min, stationary phase of a* and b* values appeared in 5 and 8 min, respectively. After the high-heating process, the stationary phase of L* and δE* appeared in 8 min and the stationary phase of a* and b* value appeared in 5 min. Conclusion: There is the correlation of processing degree between the measurement results and the perusal observation, and the result of color measurement could provide the reference for confirming optimum parameters of processing technique.

Objective To investigate the role of extracellular signal-regulated kinase1/2 (ERK1/2) in the central amygdala on fentanyl-induced hyperalgesia in rats.Methods Thirty-two male SpragueDawley rats, weighing 60-100 g, were randomly divided into 4 groups (n =8 each) using a random number table: control group (group C), fentanyl-induced hyperalgesia group (group H), U0124 group (group U1) , and U0126 group (group U2).A catheter was implanted in the central amygdale.In group C, normal saline was injected subcutaneously, and 6.5 h later dimethyl sulfoxide (DMSO) was injected via the catheter.In group H, fentanyl was injected subcutaneously to induce hyperalgesia, and 6.5 h later DMSO was injected via the catheter.In group U1, hyperalgesia was induced, and 6.5 h later ERK1 inhibitor U0124 1.5 nmol was injected via the catheter.In group U2, hyperalgesia was induced, and 6.5 h later ERK1/2 inhibitor U0126 1.5 nmol was injected via the catheter.Mechanical paw withdrawal threshold (MWT) and thermal paw withdrawal threshold (TWT) were measured before fentanyl injection, at 6.5 h after injection, and at 30 min after DMSO or U0124/U0126 administration via the catheter (T0-2).After the last measurement of pain threshold, the rats were sacrificed, and the amygdala tissues were sampled for detection of the expression of phosphorylated ERK1/2 (p-ERK1/2) by Western blot in groups C and H.Results Compared with group C, the MWT and TWT were significantly decreased at T1,2in H and U1 groups, and at T1in group U2 (P＜0.05) , the expression of p-ERK2 was up-regulated (P＜0.05) , and no significant change was found in the expression of p-ERK1 in group H (P＞0.05).Compared with group H,the MWT and TWT were significantly increased at T2 in group U2 (P＜0.05) , and no significant change was found in MWT, TWT in group U1 (P＞0.05).Conclusion ERK2 activation in the central amygdala is involved in the development of fentanyl-induced hyperalgesia in rats.