Objective:To discuss the effect of non-invasive mechanical ventilation on acute lung injury with pathologic pregnancy.Methods:A clinical retrospective analysis was carried out to investigate 45 cases of acute lung injury in pathologic pregnancy treated by non-invasive mechanical ventilation in central ICU.Results:Forty-four patients of forty-five were cured (97.8%).Only one patient(2.22%) developed ARDS,and changed to be treated by invasive mechanical ventilation.Conclusion: Pathologic pregnancy is the high risk group of AIS.Using NIPPV early is an effective way to treat,with high success rate of emergency care.The keys of treatment are early diagnosis,early treatment and monitoring of the development of ARDS.

Objective To investigate the clinical effect of Bella in the treatment of gastric ulcer. Methods According to the different treatment methods will be January 2015-2017 year in March in our hospital 120 cases of patients with gastric ulcer group: control group was treated with amoxicillin + clarithromycin + omeprazole treatment, the observation group used amoxicillin + clarithromycin + ray Bela with before and after treatment; the two groups were observed for clinical symptom score changes, the level of IL-2/IL-6/CRP the incidence of adverse reactions, and the relevant data for comparative analysis. Results Amoxicillin + clarithromycin + ray was Bella (observation group) in the treatment of gastric ulcer is better than omeprazole + amoxicillin + clarithromycin (control group) treatment, clinical symptoms score changes better than the control group, IL-2/IL-6/CRP levels than the control group, the difference was statistically significant (P<0.05); two groups of patients the adverse reaction rate comparison, the difference was not statistically significant. Conclusion The gastric ulcer patients choose amoxicillin + clarithromycin + ray Bella with significant curative effect, can improve the clinical symptoms and IL-2/IL-6/CRP level of patients, and will not increase the incidence of adverse reactions, it is worthy of widely used in the treatment of patients with gastric ulcer.

Objective:To investigate the hospital acquired pneumoma in ICU,including its morbidity rate,mortality rate,including factors,and pathogenic distribution and its drug resistance.Methods:A clinical retrospective analysis was carried out to investigate 40 cases of patients acquiring pneumonia in EICU.Results:Twenty-three of 40 cases (57.5%)died.Factors significantly predisposing hospital acquired pneumonia were tracheal intubations or tracheotomy(35%).Pathogenic bacteria Pseudomonas aeruginosa (35%) and Acinetobacter baumannii (20%) were found in most of 40 cases.And the analysis of drug sensitivity showed resistance among all the agents tested in different levels,also the multidrug resistance emerged.Conclusion:Mortality rate of HAP is found high in ICU.The leading causative microorganisms are Gram-negative bacteria,and drug-resistant bacteria.Antibiotics should be appropriately selected.

The incidence of sepsis increased year by year. A number of methods are proposed at home and abroad for the treatment of sepsis, and continuous blood purification therapy has become a hot issue. The treatment of sepsis has been well studied in different ways, especially in function and mechanism of continuous blood purification. The available data was reviewed in this paper.

Objective To investigate the effect of surgical treatment in left colorectal carcinoma with acute colorectal obstructive.Methods Clinical data of 70 patients with acute left obstructive colorectal carcinoma treated by emergent operation were collected.65 cases received one stage tumor resection and 5 cases received two stage tumor resection were retrospectively analyzed.Results The complication rate was 20.0%(14/70),mortality rate was 1.0%(1/70);radical surgery after 1,3,5-year cumulative survival rates were 100.0%,93.6%,66.7% wich were higher than the palliative surgery 69.2%,0.0%,0.0%(all P＜0.01);With univariate analysis,radical resection,Dukes stage,tumor differentiation,and chemotherapy were found to be significant factors associated with the overall survival(χ2 = 16.546,20.649,5.953,all P＜0.01);with the overall survival.With multivariate analysis,radical resection independently affected the overall survival(Wald = 5.877,P＜0.01).Conclusion One stage radical resection was feasible for left obstructive colorectal carcinoma,and could improve survival rate after operation.

Stent fracture has been implicated as a cause of drug-eluting stent failure. The authors report here 2 cases with stent fractures which were diagnosed by coronary artery angiography and intravascular ultrasound (IVUS). Both of them received multiple-stent-implantation. Five stent fractures altogether were detected in two patients. All the involved stents were sirolimus-eluting ones. Angiographic study showed that three stent fractures were complete transverse linear fracture with stent displacement. IVUS demonstrated that three stent fractures were complete break and two were partial break. One fracture was located close to the overlapping site of two stents and another fracture was accompanied by the formation of a coronary aneurysm. Angiography and IVUS are helpful to identify stent fracture. In addition, IVUS is more likely to clarify the cause of stent failure as well as the mechanism of stent fracture.

PurposeTo investigate the permeation of model drug,propranolol hydrochloride, through the excised porcine buccal mucosa. To study the influences of various factors on the buccal absorption also studied. MethodsUsing excised porcine buccal mucosa permeation test in vitro. By means of changing the medium pH, osmotic concentration, drug concentration, the concentration of various penetration enhancers including sodium glycodeoxycholate (GDC), sodium glycocholate (GC), dimethy1-β-cyclodextrin (DMβCD), and hydropropyl-β-cyclodextrin(HPβCD). The permeation rates and permeability coefficients(P) were determined and evaluated. The solubilities and apparent partition coefficients also determined in some tests. ResultsThe result showed that the P were increased when porcine buccal mucosae were pretreated with every penetration enhancement of certain concentration, increased as the pH of test solution rose from 4.9 to 9.1. The P remained constant as the concentration of propranolol hydrochloride increased from 5 to 80 mg/ml, decreased with the increasing of osmotic concentration Conclusions The absorption of propranolol hydrochloride through porcine buccal mucosa is a typical passive process, and affected by penetration enhancers, medium pH, osmotic concentration.

This report concerns an observation on the biological properties of orthomyxoviruses type A in the condition of symbiosis with streptococcus A in embryonated eggs. The results show that both the viruses and the streptococci multiply normally in the condition of symbiosis and that the activity of the virus neuraminidase enhances, with the speed of the virus disassociating from RBC increasing. The morphological changes of the virus were observed also by transmission electron microscopy. The reason of these changes is discussed,

Objective To study the combination effectof curcumin and γray on the activity of human lung carcinoma NCI-H460 cells and explore the sensitization of curcumin to γray.Methods The NCI-H460 cells proliferation were detected by MTT,the cell cycle and apoptosis by flow cytometry.The expression of Bcl-2 and Bax were detected by Western Blot and the NF-κB gene expression by RT-PCR.In addition,the mice model of lung cancer was randomly divided into 4 groups:control group,curcumin group,γ ray group and combination group.After 28 days,the tumor volume was measured.Results The proliferation and cell cycle of NCI-H460 cells were inhibited and the apoptosis was increased in combination group.In addition,compared with curcumin group or γray group,the expression of Bcl-2 was inhibited,but the expression of Bax was increased and the mRNA expression of NF-KB was inhibited in combination group(all P＜0.05).Also in combination group the tumor volume was significantly inhibited compared with curcumin group or γ ray group(all P＜0.05).Conclusion Curcumin might induce the radiosensitivity of Human Lung Carcinoma NCI-H460 cells through the pathway.

Objective: To observe the liver function changes and to analyze the risk factors in patients at peri-operative period of cardiopulmonary bypass surgery.
Methods: A total of 108 patients with cardiopulmonary bypass surgery were observed for their liver function at prior and 1, 2, 3, 6 days post-operation, the related risk factors for lever damage were studied by uni- and multivariate regression analysis.
Results: Compared with pre-operative indexes,① at 1, 2, 3 and 6 days post-operation, aspartate aminotransferase (AST), direct bilirubin (DBIL) were increased, serum albumin (ALB), cholinesterase (CHE) were decreased, and at 1, 2, 3 days post-operation, total bilirubin (TBIL) was increased, at 1, 2, 3 days post-operation, alkaline phosphatase (ALP) was decreased, while it increased at 6 days post-operation, allP<0.05;② glutamyl endopeptidase (GGT) was decreased at 1, 2 days post-operation, while it increased at 6 days post-operation,P<0.05;③glutamate pyruvate transaminase (GPT) was increased at 6 days after operation,P<0.05. Univariate regression analysis indicated that cardiothoracic ratio ≥ 0.56 (P<0.05, OR=2.900, 95% CI: 1.206~6.976), cardiopulmonary bypass time (P<0.05, OR=1.042, 95%CI: 1.017~1.068), aortic clamping time (P<0.05, OR=1.041, 95% CI: 1.012~1.070) and lactic acid level at 1 day after operation (P<0.05, OR=1.518, 95% CI: 1.182-1.948) were related to post-operative damage of liver function. Multivariate regression analysis presented that cardiopulmonary bypass time (P<0.05, OR=1.033, 95% CI: 1.007-1.059) and lactic acid level at 1 day after operation (P<0.05, OR=1.340, 95% CI: 1.028-1.745) were the independent risk factors for post-operative damage of liver function.
Conclusion: Multiterm of liver function could be damaged at the early stage after cardiopulmonary bypass surgery; cardiopulmonary bypass time and lactic acid level at 1 day after operation were the independent risk factors for peri-operative damage of liver function in relevant patients.