Objective To explore ductus venous abnormal -looking blood flow parameters and spectrum morphology in the application value of fetal congenital heart disease screening.Methods 210 cases of normal fetal antenatal examination were selected as a normal control group,48 cases of congenital heart disease the fetus,then the component type according to right heart function,to the abnormal ductus venous blood flow spectrum combined with pathologic contrast analysis.Results 48 cases of CHD in the fetus,18 cases of left heart system dysplasia,30 cases of right heart system dysplasia.In order to right heart function change respectively:right heart preload increased 15 cases,right heart load increased after 25 cases,8 cases of right heart function change was not obvious.Conclusion Ductus venous and parameters have abnormal blood flow spectrum,highly suggestive fetal congenital heart disease, especially dysplasia fetal heart right system can serve as an indicators of early screening for CHD.

Objective To investigate the subjective well-being and its influencing factors of the advanced elderly in the community. Methods Totally 409 cases aged 80 years and over in five communities of Hang zhou city were surveyed using Memorial University of Newfoundland Subjective Well-bing Scale. Results The subjective well-being of the advanced age people was at a high level.The cases with good hearing,well eyesight,income from own source,monthly income between 1000-3000 yuan,health satisfaction and frequently or occasionally regular interest in the activities had higher subjective well-being(all P＜0.05).Subjective well-being was not significantly affected by age,sex,level of education (P＞ 0.05). Conclusions Subjective well-being of aged people is mainly affected by state of health and economic resources.

Objective To discuss the effect of targeted information support on the sense of uncertainty and anxiety among patients treated with percutaneous coronary intervention and its instructive significance to nursing work.Methods We randomized 118 patients treated with percutaneous coronary intervention whose sense of uncertainty and anxiety were relative intensive into the test group and the control group with 59 cases in each group.We gave routine health instructions to the control group while targeted information support besides routine health instructions to the test group.We investigated the patients in two groups by Chinese version of uncertainty scale and State Anxiety Inventory at 4 time points,that is ,the first day in hospital,night before the operation,24 hours after the operation and 1 day before leaving hospital.Results The anxiety level and sense of uncertainty about illness decreased at the night before operation,24 hours after operation and 1 day after operation compared with the control group.The sense of uncertainty and anxiety level has statistical difference between whatever two adjacent time points except for anxiety level between the time points between the first day in hospital and before operation.Drop of sense of uncertainty at 24 hours after operation was significantly different between the two groups(P<0.01).Conclusion Supplying targeted information support could decrease the sense of uncertainty and anxiety among patients treated with percutaneous coronary intervention.

Amino Acid Metabolism, Inborn Errors ; Humans ; Mitochondrial Diseases ; Sarcosine Dehydrogenase ; deficiency

Histone deacetylase 6 (HDAC6) is an unique subtype of histone deacetylases with two tandem deacetylase domains and substrate specificity for non-histone proteins. It is involved in many important physiological and pathological processes and has become a promising therapeutic target in recent decades. Different kinds of potent HDAC6-selective inhibitors have been reported around the world. This paper reviews the progress in the study of structure and functions of HDAC6 as well as the development of HDAC6-selective inhibitors.
Histone Deacetylase Inhibitors ; pharmacology ; Histone Deacetylases ; chemistry ; Humans ; Substrate Specificity

Clinical Trials as Topic ; Dentistry ; Humans

Good palatability of pediatric drugs improves the accuracy of dosing and adherence to dosing regimens. Many active pharmaceutical ingredients have an undesirable taste, so effective taste masking methods need to be developed to improve the palatability of pediatric medicines. This article mainly introduces the commonly taste masking techniques and taste evaluation methods, and puts forward suggestions on the concerns and general principles of the pharmaceutical evaluation of taste masking effects based on cases, in order to provide reference for the development of drug taste masking technology in children.

Objective To evaluate the effects of aerobic exercised on patients with depression.Methods Patients with depression according to the Chinese classification of mental disorders criteria were recruited during January 2011 to December 2012.Patients were divided into exercise group and control group randomly.The Hamilton Depression Rating Scale (HAMD) was used to evaluate the depressive symptom of patients.Patients in exercise group were divided into low intensity aerobic exercise,3 sessions per week and 5 sessions per week,and high intensity aerobic exercise 3 sessions per week and 5 sessions per week.Stretching exercises worked as a control.The four exercise groups were compared with stretching exercise group with efficiency.The control group was treated with pharmacotherapy and psychotherapy.The HAMD scores of aerobic exercise group with different intensity and frequency were compared with the scores of control group after the 1,2,4and 6 weeks of treatment.Results High-dose exercise was more effective in treating depression compared with stretching(P ＜ 0.05),but low-dose exercise did not produce the desired benefits.The scores of patients with high intensity aerobic exercise 3 sessions per week were significantly different from scores of control group after 6 weeks treatment,and the scores of HAMD were (10.72 ± 2.45) and (15.22 ± 4.13).The scores of patients with high intensity aerobic exercise 5 sessions per week were significantly different from scores of control group after 4 weeks treatment,and the scores of HAMD were (14.15 ± 3.25)and(18.31 ± 3.32).Conclusion High intensity and high frequency aerobic exercise could significantly reduce depressive symptoms.

sFas and Bcl-2 in serum were detected by ELISA in 30 patients with Graves′ disease (GD) before and after treatment 〔(0.76?0.24)ng/L vs (1.02?0.23)ng/L, (0.52?0.08)ng/L vs (0.87?0.15)ng/L〕 and in normal control subjects 〔(0.53?0.09)ng/L; (0.81?0.15)ng/L〕, the results indicated that sFas and Bcl-2 seem to be involved in the pathogenesis of GD.

Objective To investigate the effect of propofol on hypoxic pulmonary vasoconstriction(HPV)and assess the underlying mechanism in rats.Methods Twenty male SD rats weighing 300-400 g were.anesthetizedwith intraperitoneal phenobarbital.Heart and lungs were removed after thoracotomy.Pulmonary.arterial rings 4 mmin length and 1.0-1.4 mm in diameter were prepared and suspended in Earl solution maintained at 37℃ with a pHof 7.40 and aerated with 20% O_2-5% CO_2-25% N_2.The rings were stimulated with phenylephrine(PE)10~(-6)mol?L~(-1) with different preloads(300,500,700,900,1 100 mg).The isometric tension of the arterial rings wasmeasured.The optimal preload was determined to be 900 mg which allowed best contractility.Hypoxia was inducedby aerating the solution with 95% N_2-5% CO_2 and the flow rate was adjusted to maintain PO_2 of the solution at40-20 mm Hg and pH at 7.40.HPV of the rings were recorded.Then propofol was added to achieve a finalconcentration of 1,3,10,30,100 ?mol?L~(-1) and HPV was again induced and the changes in HPV wererecorded.In addition the effects of propofol(10,30 ?mol?L~(-1))on vasoconstriction produced by KCI and PE werealso measured.Results The lower doses of propofol(10 ?mol?L~(-1))significantly inhibited HPV(P