Breast Neoplasms ; pathology ; Female ; Humans ; Middle Aged ; Neoplasm Metastasis ; Neoplasms ; pathology ; Nose Neoplasms ; secondary ; Skin Neoplasms ; secondary

How to acquire new tumor antigens is a hotspot in cancer research currently.According to the nature of antigen epitope binding its ligand,we can identify and get unknown antigen epitope even its amino acid sequence through some analytical techniques and experiments,from T lymphocytes and monoclonal antibody levels.So the molecular mechanisms of tumor immunity will be more distinct.

Objective To explore the clinical value of combined detection of antiperinuclear fac-tor (APF) ,anti-RA keratin antibody (AKA) and anticyclic citrullinated peptide antibody (anti-CCP) in diagnosis and differential diagnosis of rheumatoid arthritis (RA). Methods Totally 119 RA pa-tients,101 non-RA rheumatisants and 39 healthy controls were enrolled in the study. Enzyme linked immunosorbent assay (ELISA) was applied to quantitately detecting anti-CCP antibody; immunofluo-rescence method was applied to quantitately determining AKA and APF. Then the quadruple tabular form was used to calculate the sensitivity and specificity. Results In RA group,the sensitivity of APF, AKA and anti-CCP antibody was 48.8% ,32.3% and 83.5% respectively; the specificity was 92. 2%, 93. 1% and 94.1 % respectively. Conclusion Three autoantibodies,including APF,AKA and anti-CCP antibody have high specificity in early diagnosis of RA. Combined detection of the three antibodies con-tributes to diagnosis and differential diagnosis of rheumatoid arthritis (RA).

BACKGROUND: The discrepancies of the ideal self and the actual self (called as type A in this article), the objective self and the actual self(called as type B), the looking glass-self and the actual self(called as type C) are important study subjects and closely related to health psychology.OBJECTIVE: To probe into relationships between the discrepancies of type A, B, C self-concepts and mental health about Chinese college students, and try to provide scientific basis for mental health education of college students.DESIGN: Sampling investigation and cross-sectional study design based on the college student SETTING: Department of Psychology of Capital Normal University. PARTICIPANTS: From January to March 2002, in Beijing, we randomly chose 337 undergraduates who were of grade 2-3 from 9 classes in China University of Political Science and Law University(97 students), Universityof Petroleum, Beijing(85 students), China Public Security University(103students) and Capital Normal University(52 students). In Shanghai, Shanghai University(150 students from 7 classes in grade 2): In Changchun, Northeast Normal University(120 students from 4 classes in grade 1 -2).The total of participants were 607, but 51 participants were excluded for all kinds of reasons, at last, 556 valid participants took part in this study.METHODS: The self-concept-scale questionnaires was used for this study,including four subscales of the ideal self, the actual self, the object self and the looking-glass-self which were used to measure Chinese undergraduates'self-concept-discrepancies of A, B and C types; symptom checklist-90 scale (called SCL-90) was used to measure undergraduates' mental health. MAIN OUTCOME MEASURES: The self-concept-discrepancies of three types(A, B, C), mental health and their relationships of Chinese college students. RESULTS: ① The descriptive statistics about the discrepancies of self-concepts of three types(A, B, C) of college students: type A (65.0±39.2)discrepancy was bigger than type B(-30.1± 28.2); type B was bigger than type C (-0.11± 24.7); ② Compared to the adult normal of symptom checklist-90(SCL-90), the college students responded to SCL-90 was normai, showing majority of college students were mental healthy; ③ Type A and B discrepancies of college students significantly correlated with 10 factors of SCL-90(P＜0.01), whereas the correlation between type C discrepancy and 10 factors of SCL-90 was not significant; ④ Regression analyses predicting SCL-90 showed that A type(β=0.32) discrepancy contributing to SCL-90 was more bigger than type B (β= 0.24), type B was more bigger than type C (β= -0.14).CONCLUSION: The correlation of the discrepancies of the ideal self and the actual self, the discrepancies of the objective self and the actual self withmental health were statistically significant; but the correlationof the discrepancy of the looking-glass-self and the actual self with mental health was not statistically significant.

Objective To investigate the D-in patients with severe trauma in two dimers (D-D),fibrinogen (Fbg) and platelet parameters (PLT,MPV,PDW) level induced by postoperative deep vein thrombosis (DVT) in the formation of value in clinical diagnosis.Methods Eighty cases of healthy people as control group,were compared before and after operation and level and 321 severe traumatic patients were measured before surgery,after 1 days and 3 days of D-D,Fbg and platelet parameters,trauma were divided into fracture,traumatic brain injury,multiple injuries in three groups.Results Different trauma patients with D-D,Fbg concentration and platelet index compared with the control group increased obviously significant (P ＜ 0.05),especially the brain trauma and multiple injuries in two group increased significantly (P ＜0.01),the positive rate of D-D was 22.8％,35.2％,40.9％.Postoperative 1D in addition to brain injury group,trauma group D-D levels compared with those before operation were significantly increased with significant (P ＜ 0.05),other indicators compared with preoperative changes little,the positive rate of D-D increased slightly,but without statistical significance.Levels of Fbg 3D after the trauma group decreased significantly,D-D increased significantly,decreased the number of PLT,MPV,PDW value increases,the value of preoperative has the remarkable significance (P ＜ 0.01 or P ＜ 0.05).The positive rate of D-D was increased up to 41％,59.2％,62.3％,compared with those before operation by chi-square test was significant (P ＜0.01).Conclusion The patients with severe trauma patients after two D-dimer concentration should be alert to the occurrence of DVT,contribute to the clinically as soon as possible to take measures to avoid,there is an important clinical significance in the treatment and prognosis of trauma patients.

Objective examine the current status of Science and Technology Novelty about Medicine and Health Sciences in the Guangzhou Military Region during 2010 to 2013.Methods Using Microsoft Excel software to conduct statistical analysis on data that including the novelty of the client' s new projects,subject classification,the level of project award application,client unit,type of requested projects,innovative items,etc.Results The total number of applying for project innovation checking showed a decreasing trend in the Guangzhou Military Region;the majority of awarded application was for the third Prize;and the requirested for new project innovation checking is far less than project innovation award checking.Conclusions The center should actively promote the understanding for the innovation of the new projects among the research groups,and improve the class of prize award.

Evaluation methods of chronic sinusitis ( Visual Analogue Score and Lund-Kennedy Score) were recom-mended by the 2009 Chinese Medical Association otolaryngology head and neck surgery to nasal Science Group,and retrospective analysis of the functional endoscopic sinus surgery for noninvasive fungal sinusitis treatment effect of 143 patients. VAS of preoperative was 5.8±1.0,postoperative score was 3.9±1.0, 2.4±0.9 after 3 months,6 months, respectively (P<0.01). Lund-Kennedy Score of preoperative was 7.7±2.1, postoperative score was 3.7±1.9, 1.6±1.4 after 3 months,6 months respectively (P<0.01).

This paper analyzes the necessity of offering medical English courses at the preclinical stage,introduces the online medical English listening course,summarizes its characteristics:rich in content,highly interactive,quick in feedback,fair in assessment,and puts forward some suggestions for perfecting this course in the future.

After the specific tools and process to mine and collect subject hotspot information from papers pub-lished in English journals,Chinese journals and patents were summarized in order to standardize,schematize,simplify and clarify information collection, mange information service and insure subject hotspot information quality, the push methods and contents of subject hotspot information were described with measures proposed for the solution of problems in subject hotspot information service.

Objective To evaluate the effects of preoperative sleep disturbance on the consumption of propofol during the period of general anesthesia and postoperative sleep quality.Methods Sixty-five patients scheduled for elective thyroidectomy surgery under general anesthesia were enrolled in the study.According to the preoperative Pittsburgh Sleep Quality Index (PSQI) score,the patients were divided into sleep normal group (n =33) and sleep disorder group (n =32).Anesthesia was induced and maintained with propofol given by closed-loop target-controlled infusion (CLTCI).The consumption of propofol during the period of general anesthesia,postoperative sleep quality in the evening of surgery and at 24 h after operation,and the painful levels of the patients at 1 d and 2 d after operation were compared between two groups.Results The totalconsumption of propofol in sleep disorder group [(1 024.33 ±213.02)mg] was more than that in sleep normal group [(892.25 ± 242.30) mg] (P ＜ 0.05),and the dosage of unit surface area per minute of propofol in sleep disorder group [(4.94 ± 0.80) mg/(min · m2)] was also more than that in sleep normal group [(4.45 ± 0.96) mg/(min · m2)] (P ＜ 0.05).Each group suffered from bad sleep quality in the evening of operation,and got improvement one day later (P ＜ 0.05).The sleep quality in sleep disorder group was improved after general anesthesia (P ＜ 0.05).Conclusions Preoperative sleep disturbance increased the consumption of propofol in the general anesthesia.General anesthesia can improve the sleep quality of the patients who suffered from sleep disorder.