syuclein is regarded as a presynaptic protein, which may play an important role in neuronal plasticity. However, abnormal accumulation of fibrillar ?-synuclein and mutation of ?-synuclein gene can affect the survival of neurons. Its aggregation and interaction with other proteins are the most critical factors. ?-synuclein is a precursor of non-amyloid component of senile plaques in Alzheimers disease. It is likely that ?-synuclein is associated with Alzheimers pathology. In this paper, we summarize the progress in the normal physical function of ?-synuclein and the mechanism in Alzheimers disease.

Accidents, Occupational ; economics ; Humans ; Insurance ; legislation & jurisprudence ; Rural Population ; Workers' Compensation ; economics ; legislation & jurisprudence

Objective Analyzing the nonlinear dynamics of the TCP-RED congestion control system is of great importance. This study will help investigate the loss of stability in Internet and design a proper method for controlling bifurcation and chaos in such system. Methods Based on bifurcation diagram, the effect of parameter on system performance is discussed. By using the state feedback and parameter variation strategy, a simple real time control method is proposed to modify the existing RED scheme. Results With our control method, the parametric sensitivity of RED mechanism is attenuated. Moreover, a sufficient condition on the robust stability of the system is also derived to adjust the parameters in TCP-RED system. Conclusion The proposed method has the advantages of simple implementation and unnecessary knowledge of the exact system.

The results of comparing the social anxiety between the college students of China and the USA show that there is big difference between them but no significant difference between males and females.The scores of IAS of the students from villages are significantly higher than those from city.There is significant difference between college students and postgraduates and no remarkable difference between the other students of different academic degrees.Totally,the social anxiety level gradually goes down with the increase of degree.Science students' IAS level is significantly higher than that of art students.Insignificant difference is indicated between the students from one-child families and those from non-one-child families,but greatly significant difference between student leaders and non-student leaders.

Although non-invasive images provide primary diagnosis for coronary artery lesion in Kawasaki disease patients,coronary angiography(CAG) remained to be considered as a gold standard for delineating the anatomy of the dilated or stenosis coronary arteries.The indications of CAG,timing,key points of the procedure and also percutaneous coronary intervention are discussed.

OBJECTIVE： A RP-HPLC method for determination of ribavirin in ribavirin eye drops was developed.METHODS： In the method,μ Bondapak C18 ODS was used as the stationary phase and water as the mobile phase with the detection wavelength at 207nm.RESULTS： The linear range of ribavirin was 12.5～100.0μ g/ml(r=0.9 994,n=5).The average recovery rate was 98.47％ ,RSD=0.92％ (n=5).CONCLUSION： This method is accurate,rapid and simple for the determination of ribavirin in ribavirin eye drops.

Objective To assess the clinical efficacy and side effects of thalidomide in combination with dexamethasone in the treatment of previously untreated patients with multiple myeloma ( MM ). Methods Eighteen MM patients were treated with thalidomide combined with dexmethasone. Thalidomide was given orally at an initial dose of 100 mg/d once per night, and then gradually increased to the maximum dose of 400 mg/d at a rate of 100 mg/d per week, according to individual tolerance. Dexamethasone was given at 40 mg/d either orally or intravenously on days 1 -4,9 - 12 and days 17 -20. All patients were treated at least for 3 cycles, with twenty-eight days as a cycle. Results The overall efficacy of the 18 patients was 78% ,among which,2 cases achieved complete remission (CR) (11%) ,4 cases achieved partial remission (CR)(22% ), and 8 cases had improvement (45%) ,while 4 cases had no effect (22%) .The main side effects included constipation, hypersomnia, fatigue and acroanesthesia. Conclusions The combination of thalidomide with dexamethasone is effective in patients with previously untreated MM ,with slight side effects and high tolerance.

Critically ill children are often complicated with multiple organ damage. When the pancreas was involved, kinds of pancreatic enzymes would elevate, which suggested the high risk complication of pancreatic damage was really existed. The changes of pancreatic enzymes under different critical conditions such as shock, surgery, injury, etc. were reviewed, as well as the clinical significance of different pancreatic enzymes, so as to provide evidence for acknowledge the early biological signs in early phase of critically ill children with pancreatic damage,to decrease the mortality of complications and to improve the prognosis of critically ill children.

Objective To analyze the characteristics of upper gastrointestinal bleeding in geriatrics, Methods To analyze retrospectively the clinical data of 107 geriatric upper gastrointestinal bleeding confirmed by gastroscope or operation and another 136 non - geriatric upper gastrointestinal bleeding cases were compared. Results The most common reason of upper gastrointestinal bleeding in geriatrics is peptic ulcer(34. 58% ) .followed by gastric cancer with 18. 69%. 28. 03% of bleeding did not have typical clinical manifestation. The rates of re - bleeding, multi - bleeding and heavy bleeding were 64. 48% ,21. 5% and 2804% , respectively. The bleeding time more than one week occurred in 25. 23% of the patients,bleeding mortality was 13. 08% . 27. 10% of patients were misdiagnosis at primary visit, which had statistical difference comparing with non - geriatric patients,P

Objective To investigate the effect of dopamine pretreatment on the renal immunocompetence in a rat brain death animal model.Methods Dopamine (2, 6, 10 and 14??g?kg -1 ?ml -1 ) was continuously infused intravenously in a rat brain death animal model. 6 h later, the kidney was removed for immunohistochemical assay. Results Dopamine pretreatment could inhibit the infiltration of renal monocytes, and the expression of MHC II and P selektin in a dose dependent manner.Conclusion Dopamine pretreatment could obviously reduce the renal immunocompetence in a rat brain death model.