1.ANALYSIS OF THE NECESSITY AND VALUE OF PUBLIC HOSPITALS COMBINING WITH SOCIAL CAPITAL
Modern Hospital 2015;(6):1-2
Promoted vigorously by state and government , it is a strategic emphasis of a new round of medical reform that public hospitals combine with social capital .In order to expect more attention to the hot issue from wheth-er theoretical or practical views , this article draws lessons from the experiences that foreign hospitals have managed to combine with social capital , to analyze the necessity of the new medical mode under the background of the medical re -form policies implementation and the enlarged health industry flourishing development , and meanwhile to discuss the value of the new medical mode for the present medical situation .
2.LC-PDA-MS/MS analysis and anti-depressant study of Zhizi-Gancao-Chi decoction
Journal of China Pharmaceutical University 2009;40(4):342-347
Aim: To establish an analytical method to study the chemical components in Zhizi-Gancao-Chi(ZGC) decoction, and investigate its anti-depressant effect. Methods: An LC-PDA-MS/MS method was established and applied. The separation was performed on an ODS C_(18) column (250 mm ×4. 6 mm, 5 μm) with a gradient elu-tion. The mobile phase consisted of water/acetic acid( 1 %, v/v) and methanol. The main components were identi-fied according to the UV and MS. The anti-depressant effect was evaluated with mice tail-suspension test and forced swimming test. Results: The components of the ZGC decoction were separated isolated and ten of them were identified. These compounds are classified to iridoid glycosides, flavonoids and triterpene saponins. In addi-tion, its anti-depressant effect was observed for the first time. Conclusion: The LC-PDA-MS/MS method can ef-fectively separate and identify the components of ZGC decoction, which has significant anti-depressant effect. The relationship between the chemical component and its anti-depressant effect needs further study.
3.Discussion of vancomycin dosage in Chinese adult patients
Jie FANG ; Le HE ; Qijian CHENG
Chinese Journal of Infection and Chemotherapy 2014;(4):291-294
Objective To study whether vancomycin dosage 2 g daily in Chinese adult patients would achieve the target serum trough concentration of 10-20 mg/L.Methods The data of 122 adult inpatients under therapeutic drug monitoring while receiving vancomycin were collected from September 2011 to December 2012.The correlation between vancomycin trough concentration and dosage,age,sex,body weight,concomitant medications were analyzed retrospectively.Results Vancomycin trough concentration was below the target concentration in 62.1% of the included patients.Age is an independent risk factor for attainting target concentration.Serum concentration was below target concentration in 70.0% of the patients below 60 years of age.Serum concentration was above target concentration in 62.5% of the patients above 60 years of age.Conclusions Clinicians and pharmacists should assess the dosage regimen of vancomycin cautiously,and age should be considered especially as an independent risk factor.
4.Treatment of 60 Cases of Senile Herpes Zoster by Encircled Acupuncture plus Valaciclovir
Yingdan HE ; Ruihua FANG ; Le KUAI
Journal of Acupuncture and Tuina Science 2007;5(3):171-173
To observe the clinical therapeutic effect and safety of local encircled acupuncture plus valaciclovir in treating senile herpes zoster.Methods:Sixty senile patients with herpes zoster were divided into two groups.In acupuncture and medicine group,the patients were treated by encircled acupuncture plus valaciclovir.The needle was inserted about 0.8 cun away from herpes and to form an angle of 15°with the skin around the skin lesion.During treatment,valaciclovir was taken orally 300 mg every time,twice every day for successive 10 days.In westem medicine group,valaciclovir was taken orally 300 mg every time,twice every day for successive 10 days.Results:The time of stopping herpes,relieving pain andscabbing in acupuncture and medicine group was significantly lower than that in western group.Conclusion:Local encircled acupuncture plus valaciclovir in treating senile herpes zoster got effects quickly and could effectively shorten the course of disease and reduce the incidence rateofresidual neuralgia.
5.A case report of a bronchial foreign body removal by direct laryngoscopy with fiber bronchoscope.
Le SUN ; Ning FANG ; Yan ZHANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(23):2089-2090
An 11 year old girl presented with dyspnea and a rough cough, after having mistakenly swallowed a steel ball and unable to relieve the symptoms. Chest X-ray showed an image consistent with a 10 mm diameter circular object, embedded in the right mainstem bronchi near the fifth thoracic level and the medicastinal moving to the right. A clinical diagnosis based on these findings: foreign body of the right bronchial.
Bronchi
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pathology
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Bronchoscopes
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Bronchoscopy
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Child
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Female
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Foreign Bodies
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surgery
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Humans
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Laryngoscopy
6.Analysis of governmental responsibilities in health protection as inspired by the model of Sanming's healthcare reform
Siyu TAO ; Hong LE ; A'hong HUANG ; Pengqian FANG ; Fang WANG ;
Chinese Journal of Hospital Administration 2017;33(4):252-254
Success of Sanming's heahhcare reform relies heavily on the government's dominant role.Based on this inspiration,the paper discussed the responsibilities expected of the government in health protection of the people as required by national strategy,public interests and market demands,and presented the corresponding responsibilities of the government in the protection,leadership,scrutiny and management for the sake of public health.In addition the paper recommended on policies to make up for the absence and dislocation of governmental responsibilities,including all-out efforts for legislations in health protection,greater government subsidy for health protection,development of a comprehensive supervision system,and establishment of entities accountable for people's health in general.
7.A preliminary study on the establishment of rat model with acute hyperuricemia
Li XU ; Le SHI ; Fang ZHAO ; Qiuwei TAN ; Jinliang YAO
Chinese Pharmacological Bulletin 2003;0(07):-
Aim To observe the fluctuation of uric acid in serum after replicating rat hyperuricemia model with hypoxanthine, uricase inhibitor singly or combined. Discuss the method of acute hyperuricemia replication on rats. Method Hypoxanthine was administered via stomach, uricase inhibitor was injected intraperitoneally, then inspect the uric acid in serum at different periods of time. Results When we combined hypoxanthine with uricase inhibitor, the uric acid in serum of different dose groups was higher than control group after 3 hours(P
8.Expression of human protection of telomere 1 and its relationship with Helicobacter pylori infection in gastric carcinoma
Fang YUAN ; Chunming LI ; Lifeng WANG ; Tao LE ; Hongqiu HE
Cancer Research and Clinic 2016;28(3):165-168
Objective To determine the expression of human protection of telomeres 1 (hPOT1) and its relationship with Helicobacter pylori (HP) infection in gastric carcinoma.Methods The expressions of hPOT1 protein and hPOT mRNA were detected in 53 gastric carcinoma specimens (observed group) and 20 normal gastric mucosa tissues (control group) by SP immunohistochemical method and in situ hybridization (ISH), respectively.HP infection was examined by Warthin-Starry method in observed group.Results The positive expression rate of hPOT1 protein was 84.91% (45/53) in observed group, higher than that in control group [30.00 % (6/20)] (P < 0.01).The positive expression rate of hPOT1 mRNA was 58.49 % (31/53) in observed group, higher than that in control group [10.00 % (2/20)] (P < 0.05).The positive co-expression rate of hPOT1 protein and mRNA was 56.60 % (30/53), both had positive relationship in gastric carcinoma (r =0.394, P < 0.05).The rate of HP infection in 53 cases of gastric carcinoma was 52.83 % (28/53).The positive expression rates of hPOTI protein and mRNA in observed group with HP infection were significantly higher than those in observed group without HP infection[protein: 96.43 % (27/28) vs 72.00 % (18/25), P <0.05;mRNA: 85.75 % (24/28) vs 28.00 % (7/25), P < 0.01].Conclusions hPOT1 may be associated with occurrence of gastric carcinoma.Combined detection of hPOT1 protein and mRNA can be used for the diagnosis of gastric carcinoma.HP infection may be associated with abnormal expression of hPOT1 in occurrence of gastric carcinoma.
9.Hidden blood loss after primary total hip arthroplasty:analysis of influential factors
Haiyong XU ; Ming ZHANG ; Huaixi FANG ; Guoping LE
Chinese Journal of Tissue Engineering Research 2015;(13):1974-1978
BACKGROUND:The hidden blood loss, accounted for a fairly large proportion of perioperative blood loss in total hip replacement, can seriously affect the recovery of postoperative joint function, but the specific influential factors and mechanisms remain unknown at present. OBJECTIVE:To evaluate the relative influential factors for hidden blood loss after primary total hip arthroplasty by the blood loss condition, and to analyze the association between hidden blood loss and prognosis. METHODS:Clinical data of 110 patients who underwent primary total hip arthroplasty in the Liuzhou Worker’s Hospital between April 2011 and April 2013 were retrospectively analyzed. The hidden blood loss was calculated according to Ward and Gross formula. The effects of patient’s gender, age, body mass index, type of prosthesis, presence of internal diseases, and different causes of a disease on hidden blood loss after arthroplasty were analyzed. The patients were divided into the high blood loss group (≥ 480 mL) and the low blood loss group (<480 mL) according to the hidden blood loss. Al the patients were fol owed up for 1 year. The Harris hip score system was used to assess the recovery of hip joint function between the two groups. The correlation between hidden blood loss and the recovery of joint function was analyzed using Pearson’s correlation analysis RESULTS AND CONCLUSION:The total blood loss of primary total hip arthroplasty was (1 340±367) mL, and the hidden blood loss was (748±324) mL, and the percentage of hidden blood loss was 53.7%. The type of prosthesis, presence of internal diseases, and different causes of a disease were significantly associated with hidden blood loss after total hip arthroplasty (P<0.05). Gender, age, body mass index, and operation time were not significantly associated with hidden blood loss after total hip arthroplasty (P>0.05). The hidden blood loss was correlated with postoperative functional recovery (P=0.046). Results indicated that type of prosthesis, presence of internal diseases, and different causes of a disease are main influential factors for hidden blood loss after total hip arthroplasty. The hidden blood loss has some influence on the recovery of postoperative joint function.
10.Clinical Study on Infantile Congenital and Non-Congenital Cytomegalovirus Infection
rong, MI ; fang-sheng, XU ; cong-le, ZHOU
Journal of Applied Clinical Pediatrics 2006;0(22):-
Objective To learn the damage on infants and effect of treatment of congenital cytomegalovirus(CMV) infection and non-congenital cytomegalovirus infection which included perinatal infection and postnatal infection.Methods According to the diagnosis standard of cytomegalovirus infection in China,46 infants diagnosed CMV infection were retrospectively reviewed.In this research,CMV infection was diagnosed if serum CMV-IgM or CMV-pp65 in polymorphous leukocytes was positive.According to beginning time of CMV infection symptom,46 cases were divided into 2 groups: congenital infection and non-congenital infection,clinical features of 2 groups were compared.Ganciclovir was given to the infants with infantile hepatic syndrome of 2 groups,and compared liver transaminases and bilirulin with itself after treatment,side-effect was observed.Infants of 2 groups were followed up,and prognosis was compared.Results In 46 infants,21 were enrolled congenital infection group,25 were non-congenital infection group.CMV-IgM was positive in 38 cases of 46 patients,CMV-pp65 was positive in 19 cases of 43 patients,both CMVIgM and CMV-pp65 were positive in 11 cases.More congenital malformation were found in congenital group than non-congenital group,there was significant difference between 2 groups((P