Objective To study the clinical characteristics, diagnosis and treatment of childhood visceral leishmaniasis. Methods A retrospective analysis of 46 cases of children with visceral leishmaniasis was performed, epidemiological and clinical characteristics, laboratory and special inspection, diagnosis and treatment were analyzed. Results All 46 cases (27 males and 19 females) were mostly from the epidemic area and sporadically happened in spring, autumn, and winter, lacking of specific symptoms. Clinical features include long-term and repeated fever, anemia, abdominal distention and respiratory infection, the most common feature is fever accompanied with liver, spleen and lymph node enlargement. Laboratory tests were mainly found with anemia, pancytopenia in peripheral blood , damaged liver function, and elevated CRP. Bone marrow cytology smear found duchenne body- in 26 cases, the positive rate was 61.36%. Visceral leishmaniasis serological antibody were positive in 28 patients, positive rate was 96.29% (28/30). 30 cases were treated with meglumine antimoniate, 26 cases were cured, 3 cases died, and 1 case were not cured and discharged from the hospital. The treatment effective rate was 86.67%. Conclusions Childhood visceral leishmaniasis is still popular in recent years lacking of characteristic clinical symptom. Therefore, for the patients in the epidemic area who presented with long-term fever, anemia, or pancytopenia in peripheral blood, hepatosplenomegaly (especially the splenomegaly), and liver function damage, bone marrow puncture, visceral leishmaniasis antibodies and/or RK39 dipstick test and relevant auxiliary examination should be considered for early diagnosis and treatment, thus to reduce the complications and to improve the cure rate.

Sleep disorders are main clinical symptoms in perimenopausal women. The symptoms are difficulty in initiating or maintaining sleep, early morning awakening and so on. These sleep problems had made serious im-pacts on the quality of women's life during menopausal periods. Menopausal sleep disorders can be caused by changes of serum estrogen levels, vasomotor symptoms, mood disorders and patient's state of disease. This paper presented an overview of inducing factors and current situation of menopausal disorder treatment.

OBJECTIVE To study the classification and distribution of the ?-lactamases produced by Escherichia coli in diabetic patients.METHODS To detect the ?-lactamases produced by E.coli in diabetic patients with a multi-disk synergy test.RESULTS Forty-nine strains of 60 strains in our study produced the ?-lactamases with total positive rate of 81.67%,From them 5 strains were producing penicillinases,17 strains producing BSBLs(28.33%),and 27 strains were producing ESBLs(45.00%),no carbapenem-hydrolyzing ?-lactamases were detected.In 27 strains producing ESBLs,the sensitivities to the ceftazidime,aztreonam and cefotaxime were similar.CONCLUSIONS The types of ?-lactamases produced by E.coli in diabetic patients are mainly BSBLs and ESBLs,without carbapenem-hydrolyzing ?-lactamases;the sensitivities to the ceftazidime,aztreonam and cefotaxime are similar.

Pancreatic cancer is one of the most malignant diseases.With the development of biology,its pathogenesis has become more and more clear.There are a lot of signal pathway aberrant in pancreatic cancer cell including Notch signal pathway,k-ras signal pathway,hedghog signal pathway,NF-κB signal pathway and so on.Because of the widespread of NF-κB signal pathway aberration in pancreatic cancer cell,we think that NF-κB play a key role in the various kinds of aberrant signal pathways.So the NF-κB relative sighal pathways in pancreatic cancer are reviewed in this atticle.

Morphine antagonist naloxone (3mg/kgiv ) induced a rise in blood pressure,pulse pressure & respiratory rate in the rat under hemorrhagic shock. It also improved the survival rate. ?Receptor antagonist pheno-xybenzamine ( 1 mg/kg iv ) or adrenalectomy abolished the beneficial effects of naloxone. Reserpine ( 1 mg/kg ip for 5 d) which depleted catecholamines of periphal sympathetic nervous system could not abolish naloxone effects. Resrpine plus adrenalectomy abolished naloxone actions again. It is suggested that the effect of naloxone on the blood pressure is mainly due to release of catecholamine from adrenalmedu-llary. The results of isolated adrenal perfusion indicated that naloxone could not induce a rise in catecholamine concentration of perfused liquid. It is suggested that the action of naloxone on catecholamine release may not be a result of direct action upontbe chromaffin cells.

OBJECTIVE:To study the mechanisms of GJKL(Gujikang liniment) in treatment of soft tissue injury METHO_DS:The effects of intraperitoneal injection of acetic acid solution on capillary permeability were observed;An animal model of soft tissue injury was established by striking The effects of GJKL on hemorheological parameters were observed RESULTS:GJKL markedly inhibited capillary permeability and decreased hemorheological parameters CONCLUSION:GJKL takes therapeutic effects on soft tissue injury through inhibiting the increased capillary permeability and reducing the hemorheological parameters

Objective To study the effect of IL-6 and IL-8 on the MMP-9 secretion of endometrial stromal cells in women with endometriosis to explore the function of IL-6 and IL-8 in the adherence and planting process of ectopic endometrium. Methods The endometrial stromal cells were cultured in DMEM/F12 medium containing different concentrations of IL-6 or IL-8 for 24 hours, then the media were collected to measure the levels of MMP-9 by ELISA. Results The levels of MMP-9 in control stromal cells cultured with high concentration of IL-6 were significantly higher than those without IL-6 (P

Ginsenoside Rg1 ( Rg1 ) is a monomer isolated from ginseng, which has a variety of pharmacological activities. Rg1 can obviously regulate hematopoietic stem cells, mesenchymal stem cells, neural stem cells and endothelial progenitor cells proliferation, differentiation, aging, secretion and so on by mul-tiple mechanisms. Rg1 has important therapeutic effects on the reparation of tissues, organs damage and aging. This review de-scribes the current knowledge on the effects of Rg1 on the char-acteristics and functions of adult stem cells.

Objective To investigate the expression and clinical significance of RhoC protein in breast cancer.Methods Expression of RhoC protein was detected by immunohistochemlstry in 112 cases of breast cancer,20 cases of adjscent non-cancerous normal tissues and 15 cases of normal mammary gland tissues.The relation between expression of RhoC protein and clinicopathological characteristics was analyzed.Expression of CD34 in breast cancer tissues was detected.Microvessel density(MVD)was calculated and its correlation with RhoC protein Was analyzed.Results RhoC had a positive expression rate of 40.2%(45/112)in breast cancer,while it was not expressed in adjacent non-cancerous tissues or normal mammary gland tissues.Rhoc expression in breast tissues was related to lymph node metastasis and pathological stages(P<0.05).MVD value in patients with positive RhoC expression was significantly higher than that in patients with negative RhoC expression(P<0.05).Conclusions The expression of RhoC protein is related to lymphatic metastasis,pathological stages and MVD value.The upregulation of RhoC protein expression may promote the metastasis and invasion of breast cancer.

Medical nutrition therapy (MNT)is the basic and long-term treatment of diabetes patients. At present,the dietary structure of type 2 diabetes mellitus(T2DM)patients in China has yet to be further improved. This article focused on the effect,dietary structure,food selection and guarantee of compliance of MNT in T2DM.We recommended that the dietary pattern should be designed based on the traditional dietary habits around the country,combined with people living and working reality. The rational utilization of network platform can improve the efficiency and compliance of nutrition education.