Objective To explore the safety and reliability of soft tissue high-frequency welding technique for partial hepatectomy in animals and provide evidence for its clinical application.Methods With high-frequency welding technique,partial liver tissues were removed from 10 SD rats.Intraoperative blood loss was recorded.Liver function was detected and wound healing was observed by dissecting the rats one week after operation.Results There was no hemorrhage during the liver resection.The liver function returned to normal after one week and the liver incision recovered well.Conclusion The use of soft tissue high-frequency welding technique for partial partial hepatectomy is basically free of bleeding and is safe and reliable.