Red cell deformability in diabetics is much lower than that in normal controls. In patients with diabetic retinopathy, the decrease of red cell deformability is much more prominent than in patients without. Urinary albumin excretion rate in diabetic patients is inversely correlated with red cell deformability .The data above suggest that there is a close relationship between decreased red cell deformability and microangtopathy in diabetic patients

Consumer Product Safety ; legislation & jurisprudence ; Legislation, Food

Dental Implantation, Endosseous ; Humans ; Tooth Socket ; surgery

Objective To study the relationship between the co‐expression levels of inducible costimulatory molecule (ICOS)and CD28 on peripheral blood CD4+ and CD8+ T cells and Behcet’s disease(BD).Methods Flow cytometry was used to detect the expression levels of ICOS and CD28 on peripheral blood CD4+ and CD8+ T cells of BD patients(n=22) ,including those with active BD(ABD ,n= 14)and stable BD(SBD ,n= 8) ,and of normal subjects(n= 22).Results The proportion of CD28+ ICOS+ CD4+ T cells was significantly increased in ABD patients when compared with normal subjects [(34.72 ± 12.87)% vs.(25.36 ± 8.24)% ,P<0.05].No significant difference was found in the proportion of CD28+ ICOS+ CD8+ T cells [(9.32 ± 4.57)% vs.(7.24 ± 3.36)% ,P>0.05]between the two groups.The proportions of CD28-ICOS+ CD4+ T cells and CD28-ICOS+CD8+ T cells were both obviously increased in ABD patients when compared with those in normal subjects[(2.54 ± 1.63)% vs.(0.76 ± 0.25)% for CD28- ICOS+ CD4+ T cells ,P< 0.05;(8.79 ± 3.41)% vs.(3.04 ± 1.25)% for CD28-ICOS+CD8+ T cells ,P<0.05].Conclusion The increased expression level of ICOS on peripheral blood CD4+ and CD8+ T cells is not closely associated with the expression of CD28 to some extent in BD patients ,suggesting that cells expressing only ICOS play an important role in the development of BD.

Objective To analyze the clinical value of microRNAs applied in the early diagnosis of pancreatic cancer.Methods The expression of mir-155,mir-196a,mir-181a,mir-181b in three pancreatic cancer cell lines PANC-1,PaCa-2,AsPC-1 pancreatic cancer,normal pancreatic cells and plasmas of 100 patients with pancreatic cancer ,100 normal volunteers were detected by Real-time PCR,and the results were analyzed.The expression of mir-155,mir-196a,mir-181a,mir-181b in 100 pancreatic cancer tissues and 100 normal pancreatic tissues were detected by immunohistochemical,and the results were analyzed. Results Real-timePCR test results showed that compared with normal pancreatic cells,mir-155,mir-196a expression in three pancreatic cancer cells PANC-1,PaCa-2,AsPC-1 were significantly increased(P<0.05).Compared with healthy volunteers,mir-155,mir-196a,mir-181a,mir-181b expression of plasma in pancreatic cancer patients were significantly higher(P<0.05).Immunohistochemistry results showed that mir-155,mir-196a mir-181a and mir-181b expression in pancreatic tissue were significantly higher than that in normal pancreatic tissue (P <0.05 ).Conclusion The expression of mir-155,mir-196a,mir-181a and mir-181b are high in pancreatic cancer tissues and pancreatic cancer cell lines,which are closely related to the development of pancreatic cancer.Those microRNAs are expected to be cancer markers for early diagnosis of,pancreatic cancer,have highly diagnostic value and broad clinical application.

To review the progress of small bowel lymphoma in,Pathoyeny pathology,clinical treatment and prognosis,which can effectively provide scheme for early diagnosis and therapy of small bowel lymphoma.

Objective To study the clinical effects of breast-preserving surgery in early-stage breast cancer. Methods From March 2002 to March 2007, 27 cases of early-stage breast cancer were treated with breast-preser-ving surgery. The control group had 28 cases, treated with radical mastectomy. Survival rate and recurrence rate were observed. Results The short-term progress of breast-preserving surgery in early-stage breast cancer had no significant difference with that of radical mastectomy. Plastic effects of breast were satisfied. Conclusion Breast- preserving surgery in early-stage breast cancer had favorable effects both in progress and in plastic. Therefore, it is warranted for wide use.

Objective To detect the expression of macrophage inlfammatory protein 1α(MIP-1α) in the myocardium of viral myocarditis (VMC) mice at different phases. Methods A total of 120 4-week-old male BALB/c mice were randomly divided into 2 groups, 80 in the VMC group and 40 in the control group. Mice in VMC group were inoculated intraperitoneally with coxsackievirus B3 to build VMC models, while mice in control group were treated with DMEM cultivate liquid. Ten mice of each group were sacriifced on days 3, 7, 15 and 30 after treatment and their heart tissues were collected for analysis. The level of MIP-1αin the myocardium was determined by immunohistochemistry. Myocardial histopathology was examined with hematoxylin and eosin stain. In addition, the relationship between the level of MIP-1αand the degree of myocardial lesion was investigated. Results The expression of myocardial MIP-1αprotein in VMC group was up-regulated in myocardium on day 3 after inoculation of virus, and slowly decreased after the peak on day 7, but still sustained a high level on day 30. Compared with the control group, the levels of MIP-1αin VMC group were increased signiifcantly at every phase (P<0.05). Furthermore, positive correlation was found between MIP-1αprotein expression levels and myocardial histopathologic scores in VMC group (r=0.94, P<0.01). Conclusion The up-regulated expression of MIP-1αmay play a critical role in the pathogenic mechanisms of viral myocarditis.

Non-small cell lung cancer(NSCLC) is one of the most life-threatening human malignancies due to its high morbidity and mortality rates.Molecular targeted therapy is promising in treating some patients with NSCLC.However,it is still challenging to select proper candidates.The EML4-ALK fusion oncogene represents a novel molecular target which appears mainly in lung adenocarcinoma,and appears to be a potential biomarker associated with resistance to EGFR tyrosine kinase inhibitors.This review was intended to outline current status of preclinical and clinical research of this molecule.

Objective To investigate the clinical effect of methylprednisolone and aminophylline on bronchial asthma patients, so as to improve the level of clinical treatment. Methods Selected form August 2014 to June 2016 in our hospital diagnosed with bronchial asthma in 90 patients as the research object, for the normal group and the treatment group in accordance with the double blind method standard for sharing, the former the latter with aminophylline treatment; Methylprednisolone Treatment on the basis of the former treatment. After treatment, the statistical comparison of two groups and the clinical symptoms and quality of life to improve the situation. Results the total efficiency of the treatment group was 97.8％, significantly higher than that of the control group 77.8％(P<0.05). The treatment group of clinical symptoms and signs scores were lower than those of the reference group; improving the quality of life was better than the reference group, there were significant differences between groups of data comparison, statistical significance was established(P<0.05). Conclusion Patients with bronchial asthma by aminophylline combined with methylprednisolone treatment, the effect is considerable, not only can improve the treatment effect, rapidly relieve symptoms, improve the quality of life of patients, suggest further promotion.