Genetic Predisposition to Disease ; Humans ; Non-alcoholic Fatty Liver Disease ; diagnosis ; genetics ; therapy

Elasticity Imaging Techniques ; Fatty Liver ; diagnostic imaging ; Humans

Objective To study the perinatal outcomes of pregnant women when their total stage of labor over 24 hours after the application of new partogram.Methods A retrospective case-control study was conducted on 3 991 pregnant women who received routine prenatal care and intrapartum management according to new partogram and delivered at full-term with alive babies at Beijing Obstetrics and Gynecology Hospital from October 1,2014 to January 31,2015.Among these 3 991 women,85 delivered after 24-hours' labor and all were nulliparas,while five of the 85 converted to cesarean section (CS group) and 80 delivered vaginally (study group).Another 160 primigravidas were randomly selected from those vaginal deliveries with the total stage of labor less than 24 h as control group.The general conditions,maternal and fetal perinatal outcomes were compared between the study and control group and between the study and CS group.The duration of labor was compared among different groups of women in the study group.Independent sample t-test,Rank-sum test,Chi-square test or Fisher's exact test were applied for statistics.Results The durations of first stage,second stage,third stage and total stage of labor were all longer in the study group than in the control [25.7(23.8-26.8) vs 10.4(5.9-13.9) h,1.4(0.6-1.8) vs 0.8(0.4-1.0) h,0.14(0.08-0.17) vs 0.11(0.07-0.13) h,27.2(24.9-26.8) vs 10.4(5.9 14.0) h,Z=12.525,4.359,3.528 and 12.588,all P＜0.01].The proportions of intrapartum interventions and application of labor analgesia were both higher in the study group than in the control [97.5％(78/80) vs 32.5％(52/160),42.5％(34/80) vs 11.9％(19/160),x2=90.764 and 29.071,both P＜0.01].Higher incidences of intrapartum fever [18.8％(15/80) vs 5.6％(9/160),x2=10.208],episiotomy [50.0％(40/80) vs 25.6％(41/160),22=14.172],assisted vaginal delivery [26.3％(21/80) vs 10.0％(16/160),x2=10.800],postpartum hemorrhage [32.5％(26/80) vs 8.1％(13/160),x2=23.284],and cervical laceration [15.0％(12/80) vs 3.1％(5/160),~=11.427] were shown in the study group than in the control (all P＜0.01).There was no statistically significant difference was found in the rate of fetal distress,neonatal asphyxia and neonatal intensive care unit (NICU) admission between the study and control group (all P＞0.05) except for newborns' birth weight [(3 542±388) vs (3 431 ±368) g,t=2.162,P=0.032].However,the incidences of postpartum hemorrhage,intrapartum fever and neonatal admission to NICU were comparable between the study (n=20) and CS group (both P＞0.05).Within the study group,the durations of second stage of labor in women with postpartum hemorrhage,assisted vaginal delivery and episiotomy were significantly longer than those without [1.8(0.9-3.1) vs 1.2(0.5-1.5) h,2.0(0.8-3.4) vs 1.2(0.5-1.6) h,1.7(0.6-2.6) vs 1.1(0.5-1.5) h,Z=2.168,2.756 and 1.891,all P＜0.05].Conclusions After the application of new partogram,vaginal delivery remains possible for pregnant women whose total stage of labor over 24 hours without increase of neonatal morbidity.However,the incidences of postpartum hemorrhage,episiotomy and assisted vaginal delivery may rise up.

Objective To observe the effect of artificial tears in the treatment of xerophthalmia after cataract surgery with phacoemulsification combined with intraocular lens implantation.Methods 384 patients with 384 xerophthalmia eyes after cataract surgery with phacoemulsification combined with intraocular lens implantationwere selected.They were randomly divided into observation group and control group,192 eyes in each group.Conventional therapy was given in the control group,and artificial tears was added in the observation group.The SIT,FL,BUT and adverse reactions were observed and compared.Results There were improvement of SIT,FL and BUT in both two groups after treatment.The SIT (mm/5min)in the observation group was (13.97 ±1.72),that was (9.12 ±1.02) in the control group,the improvement of SIT in the observation group was better than the control group (t =2.942, P <0.05).The FL (s)in the observation group was (2.06 ±0.37),that was (3.71 ±0.72)in the control group, the improvement of SIT in the observation group was better than the control group (t =1.776,P <0.05).The BUT (s)in the observation group was (13.26 ±2.04),that was (7.99 ±2.16)in the control group,the improvement of BUT in the observation group was better than the control group (t =4.098,P <0.05).There were 39 cases of healing eyes in the observation group,and healing rate was 27.46%.There were 21 cases of healing eyes in the control group, the healing rate was 14.79%.The healing rate in the observation group was higher than the control group (χ2 =7.748,P <0.05 ).There were 183 cases of effective treated eyes in the observation group,the effective rate was 93.66%,and there were 120 cases of effective treated eyes in the control group,the effective rate was 84.51%.The effective rate in the observation group was higher than the control group (χ2 =7.094,P <0.05).Conclusion It is effective to apply artificial tears in the treatment of xerophthalmia after cataract surgery with phacoemulsification com-bined with intraocular lens implantation and safe.It is worthy of clinical application.

Female ; Humans ; Infant ; Nasopharyngeal Neoplasms ; pathology ; Teratoma ; pathology

Gastrointestinal Tract ; microbiology ; Humans ; Metagenome ; Microbiota ; Non-alcoholic Fatty Liver Disease ; microbiology

Objective To study the therapeutic effect of co-administrated metformin and rosiglitazone in the treatment of type 2 diabetes mellitus(T2DM).Methods 53 patients with T2DM were divided into 2 groups in random:co-administrated glipizide and metformin(group A)and co-administrated metformin and rosiglitazone(group B).All cases were treated for 6 months.Blood pressure(BP),blood glucose(BG),body mass index(BMI),hemoglobin A1c(HbA1c),insulin,and blood lipid were determined and the HOMA-insulin resistance index(HOMA-IR)was calculated.Results Both treatments were effective on hyperglucose,hypertension,hyperlipidemia and high BMI(P<0.05-0.01),while group B could lower the level of insulin(P<0.05)and HOMA-IR(P<0.01).Conclusions Treatment of co-administrated metformin and rosiglitazone can improve the abnormal carbohydrate and lipid metabolism,higher levels of BP and BMI,and ameliorate insulin resistance.

Objective To discuss the effect of the sustained releasing agent FK506 on the ultrastructure of the regenerative nerve fibers.Methods The new fusiform-shaped double channel nerve conduit was used for bridge the sciatic nerve defects for 10 mm in 32 Sprague-Dawley rats.The rats were divided into Group A(100μl chitin for both channels)and Group B(chitin plus FK506 for B1 and chitin plus normal saline for B2)according to different addition of the drugs.At 8 and 12 week after operation,the middle line of the regenerated nerve was observed under the transmission electron microscope.In the meantime,an analysis was done on the area of the regenerated nerve fibers(myelinated and unmyelinated),diameter and myelin thickness of the myelinated fiber axon at 8 and 16 months.Results There was not significant difference in aspects of type and number of the regenerative nerve fibers between two channels in Group A.However,the myelinated and unmyelinated fibers of the regenerative nerves were increased in Group B1,with larger area than Group B2(P ＜ 0.05).Conclusion FK506 can significantly promote the regeneration of both the myelinated and unmyelinated fibers.

It was investigated by ~(15)N tracer that four strains capable of ammonia oxidation under the condition of limited dissolved oxygen(DO)and without organic carbon source in a sealed bio-membrane reactor.Each strain was cultured at room temperature,a sealed vessel filled with argon and an appropriate quantity of oxygen.When the condition kept DO

Animals ; CD4 Antigens ; blood ; CD4-Positive T-Lymphocytes ; metabolism ; radiation effects ; CD8 Antigens ; blood ; CD8-Positive T-Lymphocytes ; metabolism ; radiation effects ; Male ; Mice ; Ultraviolet Rays