Objective To investigate pathophysiological changes in the multifidus muscles of patients with lumbar disc herniation.Methods Thirty-six patients with unilateral symptoms caused by lumbar disc herniation were enrolled.They were divided into a symptomatic side group and a contralateral side group according to whether their symptomatic (algetic) or contralateral side would be studied.The percentage area of pimelosis and the mean gross signal intensity of each multifidus were measured with magnetic resonance imaging (MRI)_ The amplitude and duration of motor unit potentials of each multifidus were recorded using electromyography (EMG) when the patients were performing isometric contraction.Results The bilateral multifidus muscles of 36 patients displayed various degrees of pimelosis on magnetic resonance images.The percentage of pimelosis cross-sectional area in the symptomatic side group was significantly higher than in the contralateral side group.[(44.20 ± 15.14)％ versus(37.31 ± 13.85)％,P ＜ 0.05] The mean value of the gross signal intensity was also significantly higher.Both the amplitudes and duration of the motor unit potentials recroded from the multifidus had increased and widened,but significantly more in the symptomatic side group than in the contralateral side group.Conclusions Both the imaging and electrophysiological data showed more significant changes on the symptomatic side in patients with unilateral symptoms caused by lumbar disc herniation.

Circulating tumor cells (CTCs) play an important role in tumor metastasis.Detections of CTCs are contribute to tumor treatment,which can provide reliable basis for predicting the prognosis and efficacy.CTCs are related to the staging and distant metastasis of non-small cell lung cancer (NSCLC).The number changes of CTCs are associated with the chemotherapy and radiotherapy effects and prognosis in NSCLC.Almost the same phenomena have been discovered in small cell lung cancer.In the future,CTCs may be used to monitor the occurrence of drug resistant tumor cells and help individual therapy for lung cancer.

This paper presents the situation of secrecy management at colleges and universities,and analyzes the reasons for the inadequacy of capability in this aspect.From the perspective of PAEI management roles,we point out the solutions to improve the capability include strengthening leaderships,targeting,building system,managing risks and raising awareness of secrecy.

Based on recent cellular architectural studies on the bed nuclei of the stria terminalis (BST) in the rat by Ju et al, we studied vasoactive intestinal polypeptidelike immunoreactivity (VIP-LI) in the BST using PAP and ABC techniques. (1) Compared with VIP-LI cells, the VIP-LI terminals were more abundant and concentrated. At the periphery of the oval nucleus and in the juxtacapsular nucleus, there was a dense accumulation of VIP-LI terminals. Less densely innervated areas were the part above the anterior commissure in the anterior lateral area and the central part of oval nucleus. The fusiform nucleus and rostral part of the anterior ventral area contained moderate amount of VIP-LI terminals. The principal nucleus, interfasicular nucleus, posterior dorsal nucleus and dorsal nucleus, were devoid of VIP immunoreactivity. VIP-LI fiber branches were sometimes seen going along the vessels in the BST. (2) VIP-LI cells were usually distributed in areas where the terminals were relatively sparse. In the central part of the oval nucleus, the VIP-LI cells were most concentrated, though the total number of it was less than that in the caudal part of the anterior dosal area, They were usually small fusiform in shape, however some were trangular or multipolar.

As a major venue of scientific research activities,medical colleges and institutes are also an importance source of providing highly trained medical talents.With the medical education reform deepen,scientific research is now becoming the focus point of exploring the social aspect of medicine.Taking one military medical university as example,this paper demonstrated four specific measures for managing social sciences research in medical colleges.

Hilar cholangiocarcinoma is the most common types of cholangiocarcinoma,it is difficult to perform operation owing to its anatomic characterstics.Currently,radical resection is the most important prognostic factors of hilar cholangiocarcinoma.In addition,lymph node metastasis and biomarkers such as CA19-9,hepatocyte growth factor receptor,interleukin-8,and so on,are also closely related to the prognosis of hilar cholangiocarcinoma.This paper will review the relevant researches of China and abroad to summarize important prognostic factors of hilar cholangiocarcinoma above-mentioned.

Ovarian cancer bears the highest mortality in gynecologic cancer, and its 5-year survival rate is about 30%. Although 70% to 80% ovarian cancer is epithelial origin, increasing evidence indicates that reciprocal interactions between tumor cells and various types of stromal cells also play important roles in driving ovarian tumor progression and that these stromal cells represent attractive therapeutic targets. This review discusses the biological signiifcance of the cross-talk between ovarian cancer cells and three major types of stromal cells (endothelial cells, ifbroblasts and macrophages) and the development of new-generation therapies that target the ovarian tumor micro-environment.

Objective To study the expression of metallothionein(MT),Ki 67 in renal cell carcinoma(RCC) and to evaluate their biological significance. Methods The expression of MT and Ki 67 were assayed by means of immunohistochemical technique in RCC tissues and normal renal tissues.DNA content and S phase fraction(SPF) were measured by flow cytometry(FCM). Results The positive expression rates of MT in RCC tissues and normal renal tissues were 52.5%,78.9% respectively( P

Objective To assess the value of CT in diagnosis of recurrent rectal carcinoma.Methods Forty seven patients who had undergone locally curative surgery were examined by CT.All patients received intravenous contrast medium and two oral doses and a intrarectal doses of 500 ml 3% Ultravist were given.The characters of benign and malignant lesions were analysed in order to evaluate the value of the classification on CT in the differentiation of benign masses from malignant ones.Results 26 local recurrences occurred in 47 cases,including 13 cases with an round preasacral mass,8 cases with an irregular rectal wall thickening,2 cases with a flat preasacral mass,3 cases with a preasacral mass with low attenuation.The degree of enhancement of local recurrent masses was higher than that of benign masses.Conclusion The features of recurrence of rectal carcinoma on CT is an round or irregular asymmetrical preasacral mass or an irregular rectal wall thickening.It is useful way in diagnosis of recurrence of rectal carcinoma.

Objective To follow up long-term clinical events and compare the long-term prognosis between partial and complete revascularization in octogenarians with coronary artery disease.Methods A total of 108 patients aged 80-88 years who underwent elective percutaneous coronary intervention (PCI) in cardiology department of Huashan Hospital were divided into complete revascularization group (n=47) and partial revascularization group (n=61).They were followed up for long-term major adverse cardiovascular events from Jan.1 2005 to Dec.31 2008.Results There were no statistically significant differences in age,percent of female,prevalence of hypertension,diabetes,hyperlipidemia,unstable angina,smoking and renal dysfunction between the groups(all P＞0.05).And the angiography results showed no difference at the number and location of coronary artery lesions,including prevalence of single-vessel disease [15 cases(24.6％)vs.8 cases (17.0％)],dual-vessel disease [18 cases(29.5％) vs.15 cases(31.9％)] and that of tri-vessel disease [28 cases(45.9 ％) vs.24 cases (51.1 ％)] between partial and complete revascularization groups (all P＞0.05).The follow-up time in two groups were (1235±508)d and (1216±560)d (t=0.24,P＞0.05).All-cause death [ 10 cases ( 16.4 ％) vs.8 cases ( 17.0％)],cardiovascular death [8 cases (13.1％) vs.7 cases(14.9％)],hospitalization with angina [12 cases (19.7％) vs.9 cases (19.1 ％)],with hypertension [7 cases( 11.5 ％)vs.5 cases (10.6 ％)],with cardiac arrhythmia [5cases(8.2％) vs.4 cases(8.5％)],with chronic heart failure [4 cases(6.6％)vs.3 cases(6.4％)],and with all-cause cardiovascular disease [33 cases (54.1％) vs.25 cases(53.2％)] had no significant differences between partial and complete revascularization groups (all P ＞ 0.05).Conclusions Long-term prognosis of partial and complete revascularization is similar in octogenarians with coronary artery disease.