OBJECTIVE:To study the occurrence of adverse drug reaction(ADR)in our hospital and its relevant factors in order to improve the rational drug use level in the clinic.METHODS:A total of 134 cases of ADR reports collected in our hospital in 2006 were classified and analyzed statistically.RESULTS:Of the 134 cases,99 kinds of drugs were involved(in different dosage forms and specifications),leading the list were anti-infectives(34 kinds,34,34%),followed by Chinese drug preparations.Intravenous infusion(94 cases/times,59.49%)was the main route of administration;and the main types of ADR were lesions of skin and accessories.CONCLUSION:Great importance should be attached to ADR monitoring to promote rational drug use in the clinic.

Objective To investigate the effect of different analgesia during labor and their side effect to the neonates. Methods Totally 130 puerperas were randomly divided into three groups: group A included 50 puerperas with analgesia by GT-4A workstation; group B included of 40 puerperas with mixed gas analgesia consisted of 50% of nitric oxide and 50% of oxygen; and group C(40 gravidas) as control group. The analgesic effect, duration of labor, mode of delivery and the amount of postpartum hemorrhage were observed. Results The analgesic effect in group A was significantly better than group B ( P

Objective To explore the diagnostic value of secretory phospholipase A2 (sPLA2) and lysophosphatic acid (LPA) for ovarian cancer and evaluate the correlation of sPLA2 activity and LPA level to the prognosis in the patients with ovarian cancer.Methods ~3H oleic acid labeled E. coli membrane and spectrophotometry were used to detect the original and recurrent ovarian cancer. The motive observation between sPLA2 activity and LPA level was done.At the same time, The sensitivity and specificity for the diagnosis of ovarian cancer were analyzed.Results Comparing the original ovarian cancer group with the ovarian benign tumor group, the difference between sPLA2 activity (24.47 ?5.64 U/L,4.94 ?1.86 U/L) and LPA levelc(6.35 ?2.32 ?mol/L,1.92 ?0.75 ?mol/L) were significantly (P

Objective To investigate the effects of gambogenic acid(GNA) on the proliferation and apoptosis of A549 lung canc‐er cells and its possible mechanism of regulation .Methods A549 cells were treated with different concentrations of GNA ,which di‐vided into control group and GNA group(0 .5 ,1 .5 ,20 mg/L) .The cell proliferation and apoptosis of A549 was analyzed by MTT , Hoechst staining ;The expression of apoptosis‐related protein caspase3 ,caspase9 ,p53 and NF‐κB were studied by Western blot .Re‐sults GNA could inhibit growth of A549 cells ;Moreover GNA could also induce apoptosis with the concentration increased more obviously ;Western blot showed that GNA down‐regulate NF‐κB ,increased caspase3 ,caspase9 and p53 expression(P<0 .05) .Con‐clusion GNA can efficiently promote the cell proliferation inhibition and the apoptosis of A 549 cells .

Fatty Liver ; Humans

Buthionine salfoximine (BSO) is a chemotherapeutic sensitizor under clinical trial. BSO can reverse multidrug resistance in vitro and in vivo. The author reviewed the mechanism, pharmacodynamics, pharmacokinetics and the progress in clinical research of BSO. BSO is a selective inhibitor of 7-glutamylcysteine synthetase, the rate-limiting enzyme in gluthionine synthesis. Depletion of intracellular gluthionine by BSO can reverse tumor resistance to chemotherapeutic a-gents such as platinating and alkylating agents. In tumor-bearing animals BSO enhanced the therapeutic index of chemotherapeutic agents. Animals treated with BSO had a longer life span. Pharmacokinetics of BSO was a two-compartment manner in mice, dogs and huamn beings. The efficacy of BSO in cancer patients is being investigated in clinical trial.

The ratio of concentrations of D-aspartic acid and L-aspartic acid in dentin of 27 premoars of different ages was determined with chiral capillary column gas. chromatography. Acidic isopropanol and trifluoroacetic acid anhydride were derivative agents. The linear regression between the degree of racemization and age was established, r= 0. 9568, SD= 4. 5 years. This seems to be a new method which is more accurate and objective than others in age estimation with teeth.

AIM To study the effects of cyclophosphamide (CTX) on the pharmacokinetics of buthionine sulfoximine (BSO)in Walker 256 tumor bearing rats. METHODS Walker 256 tumor bearing rats were treated ip for 4 days with saline or CTX in saline (20 mg?kg -1 ), then received iv BSO 200 mg?kg -1 . BSO concentration in rat plasma was determined by a reverse phase HPLC with fluorescence detection after precolumn derivatization with o phthaldialdehyde. Compartment model and pharmacokinetic parameters were determined by 3P87 software processed on a computer. RESULTS A single intravenous dose of BSO 200 mg?kg -1 was eliminated from plasma in a two compartment manner in tumor bearing rats. The pharmacokinetic parameters of BSO were as follows: In tumor bearing control rats, T 1/2? =(11 1?2 4) min, T 1/2? =(65?14) min, CLs=(12 8?1 3) ml?min -1 ?kg -1 , AUC=(262?26) mg?L -1 ?h; in tumor bearing CTX treated rats, T 1/2? =(8 2?1 8) min, T 1/2? =(42?3) min, CLs=(13 4?1 9) ml?min -1 ?kg -1 ,AUC=(252?35) mg ?L -1 ?h. CONCLUSION There is no significant difference between the parameters of tumor bearing control and CTX treated rats except T 1/2? .

As an effective therapeutic approach for acute ischemic stroke,endovascular interventional therapy has received increasing attention.However,a large number of revascularization clinical trials have shown that its mortality rate and the incidence of complications are higher than intravenous thrombolysis.This article reviews the perioperative complications of endovascular interventional therapy of acute ischemic stroke and thek treatment.

Endovascular interventional therapy can signifantly improve the clinical outcomes in patients with acute ischemic stroke.It has become the important therapeutic means and research focus for acute ischemic stroke.However,there are many factors affecting its efficacy.This article reviews the factors affecting the treatment effect of endovascular interventional therapy of acute ischemic stroke.